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The abundant DNA adduct -methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase η.
Njuma OJ, Su Y, Guengerich FP
(2019) J Biol Chem 294: 10253-10265
MeSH Terms: DNA Adducts, DNA Damage, DNA Repair, DNA Replication, DNA-Directed DNA Polymerase, Deoxyguanosine, Humans, Molecular Structure
Added March 3, 2020
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MeSH Terms
Human DNA polymerase η has reverse transcriptase activity in cellular environments.
Su Y, Ghodke PP, Egli M, Li L, Wang Y, Guengerich FP
(2019) J Biol Chem 294: 6073-6081
MeSH Terms: Cell Line, Crystallography, X-Ray, DNA Primers, DNA Replication, DNA-Directed DNA Polymerase, Humans, RNA-Directed DNA Polymerase, Reverse Transcription
Added March 3, 2020
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MeSH Terms
Human DNA polymerase η accommodates RNA for strand extension.
Su Y, Egli M, Guengerich FP
(2017) J Biol Chem 292: 18044-18051
MeSH Terms: 8-Hydroxy-2'-Deoxyguanosine, Base Pair Mismatch, DNA Primers, DNA Replication, DNA-Directed DNA Polymerase, Deoxyguanosine, Electrophoretic Mobility Shift Assay, Humans, Kinetics, Nucleic Acid Heteroduplexes, Nucleic Acid Hybridization, Oligodeoxyribonucleotides, Oligoribonucleotides, Pyrimidine Dimers, RNA, Recombinant Proteins, Reverse Transcription, Substrate Specificity, Transcription Elongation, Genetic
Added March 14, 2018
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19 MeSH Terms
Molecular basis for PrimPol recruitment to replication forks by RPA.
Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ
(2017) Nat Commun 8: 15222
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Chickens, Chromatin, Crystallography, X-Ray, DNA Primase, DNA Replication, DNA-Directed DNA Polymerase, HEK293 Cells, Humans, Models, Biological, Multifunctional Enzymes, Protein Binding, Protein Domains, Replication Protein A, Xenopus
Added March 24, 2018
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17 MeSH Terms
Formation of S-[2-(N-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases.
Sedgeman CA, Su Y, Guengerich FP
(2017) Chem Res Toxicol 30: 1188-1196
MeSH Terms: Animals, Cattle, Chromatography, Liquid, DNA Adducts, DNA Replication, DNA-Directed DNA Polymerase, Ethylene Dibromide, Glutathione, Tandem Mass Spectrometry
Added March 14, 2018
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9 MeSH Terms
Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase η.
Patra A, Zhang Q, Guengerich FP, Egli M
(2016) J Biol Chem 291: 24304-24313
MeSH Terms: Bacterial Proteins, Crystallography, X-Ray, DNA, DNA Polymerase beta, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Humans, Sulfolobus solfataricus, Thymine Nucleotides
Added March 14, 2018
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9 MeSH Terms
Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases.
Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence MG, Lior-Hoffmann L, Fu I, Broyde S, Guengerich FP, Distefano M, Schärer OD, Sham YY, Tretyakova N
(2016) J Biol Chem 291: 23589-23603
MeSH Terms: Amination, Amino Acid Sequence, Base Sequence, DNA Adducts, DNA Replication, DNA-Directed DNA Polymerase, Guanine, Humans, Molecular Dynamics Simulation, Oxidation-Reduction, Peptides, Proteins, Recombinant Proteins
Added March 14, 2018
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13 MeSH Terms
Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.
McDonald KR, Guise AJ, Pourbozorgi-Langroudi P, Cristea IM, Zakian VA, Capra JA, Sabouri N
(2016) PLoS Genet 12: e1006238
MeSH Terms: Binding Sites, DNA Helicases, DNA Replication, DNA-Directed DNA Polymerase, Genomic Instability, Multienzyme Complexes, Protein Binding, S Phase, Schizosaccharomyces, Schizosaccharomyces pombe Proteins
Added April 18, 2017
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10 MeSH Terms
Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ.
Kim JK, Yeom M, Hong JK, Song I, Lee YS, Guengerich FP, Choi JY
(2016) Chem Res Toxicol 29: 1741-1754
MeSH Terms: DNA-Directed DNA Polymerase, Genetic Variation, Humans, Models, Molecular, Molecular Conformation
Added March 14, 2018
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5 MeSH Terms
Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.
Choi JY, Patra A, Yeom M, Lee YS, Zhang Q, Egli M, Guengerich FP
(2016) J Biol Chem 291: 21063-21073
MeSH Terms: Amino Acid Substitution, Crystallography, X-Ray, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Humans, Hydrogen Bonding, Kinetics, Magnesium, Manganese, Mutation, Missense, Protein Domains
Added March 14, 2018
0 Communities
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11 MeSH Terms