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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 28

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Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.
Seol Y, Gentry AC, Osheroff N, Neuman KC
(2013) J Biol Chem 288: 13695-703
MeSH Terms: Antigens, Neoplasm, DNA Replication, DNA Topoisomerases, Type II, DNA, Superhelical, DNA-Binding Proteins, Humans, Isomerism, Kinetics, Models, Molecular, Protein Structure, Tertiary, Sequence Deletion, Substrate Specificity
Added March 13, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I.
Gentry AC, Juul S, Veigaard C, Knudsen BR, Osheroff N
(2011) Nucleic Acids Res 39: 1014-22
MeSH Terms: Antineoplastic Agents, Cell Line, Tumor, DNA Cleavage, DNA Topoisomerases, Type I, DNA, Superhelical, Humans, Intercalating Agents, Topoisomerase I Inhibitors
Added March 13, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Circadian rhythms of superhelical status of DNA in cyanobacteria.
Woelfle MA, Xu Y, Qin X, Johnson CH
(2007) Proc Natl Acad Sci U S A 104: 18819-24
MeSH Terms: Circadian Rhythm, Cyanobacteria, DNA, Bacterial, DNA, Superhelical, Gene Expression Regulation, Bacterial, Light, Plasmids, Promoter Regions, Genetic, Transcription, Genetic
Added February 12, 2015
0 Communities
1 Members
0 Resources
9 MeSH Terms
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal.
Frøhlich RF, Veigaard C, Andersen FF, McClendon AK, Gentry AC, Andersen AH, Osheroff N, Stevnsner T, Knudsen BR
(2007) Nucleic Acids Res 35: 6170-80
MeSH Terms: Camptothecin, DNA Topoisomerases, Type I, DNA, Superhelical, Enzyme Inhibitors, Humans, Kinetics, Mutation, Plasmids, Tryptophan
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
DNA topoisomerase II, genotoxicity, and cancer.
McClendon AK, Osheroff N
(2007) Mutat Res 623: 83-97
MeSH Terms: Antineoplastic Agents, DNA Damage, DNA Topoisomerases, Type II, DNA, Superhelical, Humans, Models, Molecular, Mutation, Neoplasms
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
Bender RP, Osheroff N
(2007) Chem Res Toxicol 20: 975-81
MeSH Terms: Alanine, Amino Acid Substitution, Antigens, Neoplasm, Benzoquinones, Cysteine, DNA Cleavage, DNA Topoisomerases, Type II, DNA, Superhelical, DNA-Binding Proteins, Etoposide, Humans, Kinetics, Mass Spectrometry, Models, Molecular, Mutant Proteins, Mutation, Protein Structure, Tertiary, Quinones, Recombinant Proteins, Temperature
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes.
McClendon AK, Dickey JS, Osheroff N
(2006) Biochemistry 45: 11674-80
MeSH Terms: DNA Topoisomerases, Type II, DNA, Superhelical, Humans, Nucleic Acid Conformation, Phycodnaviridae, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.
McClendon AK, Osheroff N
(2006) Biochemistry 45: 3040-50
MeSH Terms: Antigens, Neoplasm, Antineoplastic Agents, DNA Topoisomerases, Type II, DNA, Superhelical, DNA-Binding Proteins, Dose-Response Relationship, Drug, Etoposide, Humans, Intercalating Agents, Plasmids, Recombinant Proteins, Saccharomyces cerevisiae, Time Factors
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks.
McClendon AK, Rodriguez AC, Osheroff N
(2005) J Biol Chem 280: 39337-45
MeSH Terms: Antigens, Neoplasm, DNA Replication, DNA Topoisomerases, Type II, DNA, Superhelical, DNA-Binding Proteins, Humans, In Vitro Techniques, Kinetics, Models, Biological, Plasmids, Recombinant Proteins, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
DNA ligation catalyzed by human topoisomerase II alpha.
Bromberg KD, Vélez-Cruz R, Burgin AB, Osheroff N
(2004) Biochemistry 43: 13416-23
MeSH Terms: Antigens, Neoplasm, Base Pairing, Catalysis, DNA Damage, DNA Repair, DNA Topoisomerases, Type II, DNA, Superhelical, DNA-Binding Proteins, Humans, Hydrolysis, Oligonucleotides, Plasmids, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms