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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 51

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A key interaction with RPA orients XPA in NER complexes.
Topolska-Woś AM, Sugitani N, Cordoba JJ, Le Meur KV, Le Meur RA, Kim HS, Yeo JE, Rosenberg D, Hammel M, Schärer OD, Chazin WJ
(2020) Nucleic Acids Res 48: 2173-2188
MeSH Terms: DNA, DNA Damage, DNA Repair, DNA, Single-Stranded, DNA-Binding Proteins, Humans, Magnetic Resonance Spectroscopy, Models, Molecular, Protein Binding, Replication Protein A, Xeroderma Pigmentosum Group A Protein
Added March 11, 2020
0 Communities
1 Members
0 Resources
11 MeSH Terms
Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link.
Thompson PS, Amidon KM, Mohni KN, Cortez D, Eichman BF
(2019) Nat Struct Mol Biol 26: 613-618
MeSH Terms: Crystallography, X-Ray, DNA Repair, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Escherichia coli, Escherichia coli Proteins, Humans, Molecular Docking Simulation, Protein Conformation, Thiazolidines
Added August 26, 2019
0 Communities
1 Members
0 Resources
11 MeSH Terms
HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA.
Mohni KN, Wessel SR, Zhao R, Wojciechowski AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, Cortez D
(2019) Cell 176: 144-153.e13
MeSH Terms: 5-Methylcytosine, Apurinic Acid, DNA, DNA Damage, DNA Repair, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Endonucleases, Escherichia coli, Polynucleotides, Proliferating Cell Nuclear Antigen
Added August 26, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms
The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression.
Chavez DA, Greer BH, Eichman BF
(2018) J Biol Chem 293: 8484-8494
MeSH Terms: DNA Helicases, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Humans, Protein Domains, Transcription Factors
Added August 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates.
Sugitani N, Voehler MW, Roh MS, Topolska-Woś AM, Chazin WJ
(2017) J Biol Chem 292: 16847-16857
MeSH Terms: Amino Acid Substitution, DNA Repair, DNA Repair Enzymes, DNA, Single-Stranded, Humans, Mutation, Missense, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Structural Homology, Protein, Xeroderma Pigmentosum, Xeroderma Pigmentosum Group A Protein
Added March 24, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
A whole genome RNAi screen identifies replication stress response genes.
Kavanaugh G, Ye F, Mohni KN, Luzwick JW, Glick G, Cortez D
(2015) DNA Repair (Amst) 35: 55-62
MeSH Terms: Cell Line, Tumor, Checkpoint Kinase 1, DNA Damage, DNA Repair, DNA Replication, DNA, Single-Stranded, Genome, Human, Genomic Instability, Genomics, Humans, Microscopy, Fluorescence, Protein Kinases, RNA Interference, RNA, Small Interfering
Added February 4, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.
Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA
(2015) Mol Cell 58: 1090-100
MeSH Terms: Amino Acid Sequence, Base Sequence, Binding Sites, Blotting, Western, Cell Line, Tumor, Crystallography, X-Ray, DNA, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Humans, Magnetic Resonance Spectroscopy, Models, Genetic, Models, Molecular, Molecular Sequence Data, Mutation, Nucleic Acid Conformation, Protein Binding, Protein Structure, Tertiary, RNA Interference, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Transcription Factors
Added November 10, 2015
1 Communities
1 Members
0 Resources
23 MeSH Terms
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins.
Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B
(2015) DNA Repair (Amst) 30: 1-10
MeSH Terms: Adenine, AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase, AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase, Bacteria, Bacterial Proteins, Cytosine, DNA, DNA Adducts, DNA Glycosylases, DNA Repair, DNA Repair Enzymes, DNA, Single-Stranded, Dioxygenases, Escherichia coli, Escherichia coli Proteins, Guanine, Humans, Mixed Function Oxygenases, Mycobacterium tuberculosis, Rhizobium etli, Streptomyces, Substrate Specificity, Xanthomonas campestris
Added January 7, 2016
0 Communities
2 Members
0 Resources
23 MeSH Terms
Mechanochemical regulations of RPA's binding to ssDNA.
Chen J, Le S, Basu A, Chazin WJ, Yan J
(2015) Sci Rep 5: 9296
MeSH Terms: Biomechanical Phenomena, DNA Replication, DNA, Single-Stranded, Kinetics, Models, Biological, Protein Binding, Replication Protein A, Sodium Chloride
Added March 11, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
High-affinity DNA-binding domains of replication protein A (RPA) direct SMARCAL1-dependent replication fork remodeling.
Bhat KP, Bétous R, Cortez D
(2015) J Biol Chem 290: 4110-7
MeSH Terms: Amino Acid Motifs, Bone Neoplasms, DNA Damage, DNA Helicases, DNA Replication, DNA, Single-Stranded, Electrophoretic Mobility Shift Assay, Humans, Osteosarcoma, Protein Binding, Replication Protein A, Substrate Specificity, Tumor Cells, Cultured
Added January 20, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms