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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 142

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Mechanisms and clinical course of cardiovascular toxicity of cancer treatment I. Oncology.
Yeh ETH, Ewer MS, Moslehi J, Dlugosz-Danecka M, Banchs J, Chang HM, Minotti G
(2019) Semin Oncol 46: 397-402
MeSH Terms: Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Cardiotoxicity, Cardiovascular Diseases, DNA Topoisomerases, Type II, Humans, Medical Oncology, Molecular Targeted Therapy, Neoplasms, Poly-ADP-Ribose Binding Proteins
Added January 15, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
Molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq.
Phelps HM, Al-Jadiry MF, Corbitt NM, Pierce JM, Li B, Wei Q, Flores RR, Correa H, Uccini S, Frangoul H, Alsaadawi AR, Al-Badri SAF, Al-Darraji AF, Al-Saeed RM, Al-Hadad SA, Lovvorn Iii HN
(2018) World J Pediatr 14: 585-593
MeSH Terms: Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Child, Preschool, DNA Topoisomerases, Type II, Female, Homeodomain Proteins, Humans, Immunohistochemistry, Infant, Insulin-Like Growth Factor II, Iraq, Kidney Neoplasms, Male, Multiplex Polymerase Chain Reaction, Mutation, N-Myc Proto-Oncogene Protein, Nerve Tissue Proteins, Neural Cell Adhesion Molecules, Nuclear Proteins, Poly-ADP-Ribose Binding Proteins, Receptors, Retinoic Acid, Sequence Analysis, DNA, Trans-Activators, Transcription Factors, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, WT1 Proteins, Wilms Tumor, beta Catenin
Added January 28, 2019
0 Communities
2 Members
0 Resources
29 MeSH Terms
The SUMO deconjugating peptidase Smt4 contributes to the mechanism required for transition from sister chromatid arm cohesion to sister chromatid pericentromere separation.
Stephens AD, Snider CE, Bloom K
(2015) Cell Cycle 14: 2206-18
MeSH Terms: Cell Cycle Proteins, Centromere, Chromatids, Chromosomal Proteins, Non-Histone, Chromosome Segregation, DNA Topoisomerases, Type II, Endopeptidases, Lac Operon, Mitosis, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Spindle Apparatus, Sumoylation
Added January 25, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
Oxidative Transformation of Demethoxy- and Bisdemethoxycurcumin: Products, Mechanism of Formation, and Poisoning of Human Topoisomerase II╬▒.
Gordon ON, Luis PB, Ashley RE, Osheroff N, Schneider C
(2015) Chem Res Toxicol 28: 989-96
MeSH Terms: Antigens, Neoplasm, Curcuma, Curcumin, DNA Cleavage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Diarylheptanoids, Epoxy Compounds, Humans, Oxidation-Reduction, Plant Extracts
Added October 9, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Topoisomerase II and leukemia.
Pendleton M, Lindsey RH, Felix CA, Grimwade D, Osheroff N
(2014) Ann N Y Acad Sci 1310: 98-110
MeSH Terms: Animals, Antineoplastic Agents, Catechin, Cell Transformation, Neoplastic, Chromosome Breakage, Curcumin, DNA Topoisomerases, Type II, Genistein, Humans, Infant, Leukemia, Neoplasms, Second Primary, Translocation, Genetic
Added March 13, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation.
Furniss KL, Tsai HJ, Byl JA, Lane AB, Vas AC, Hsu WS, Osheroff N, Clarke DJ
(2013) PLoS Genet 9: e1003832
MeSH Terms: Cell Cycle, Cell Cycle Checkpoints, Cell Cycle Proteins, Checkpoint Kinase 2, Chromosome Segregation, DNA, DNA Topoisomerases, Type II, Humans, Kinetochores, Mad2 Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Added March 7, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
Aldred KJ, Schwanz HA, Li G, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N
(2013) ACS Chem Biol 8: 2660-8
MeSH Terms: Anti-Bacterial Agents, Antigens, Neoplasm, Bacillus anthracis, Cations, Divalent, DNA Cleavage, DNA Topoisomerase IV, DNA Topoisomerases, Type II, DNA, Bacterial, DNA-Binding Proteins, Drug Resistance, Bacterial, Humans, Kinetics, Magnesium, Mutation, Quinazolinones, Quinolones, Recombinant Proteins, Species Specificity, Structure-Activity Relationship, Water
Added March 7, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Etoposide catechol is an oxidizable topoisomerase II poison.
Jacob DA, Gibson EG, Mercer SL, Deweese JE
(2013) Chem Res Toxicol 26: 1156-8
MeSH Terms: Catechols, Cytochrome P-450 CYP3A, DNA, DNA Breaks, Double-Stranded, DNA Topoisomerases, Type II, Etoposide, Humans, Oxidation-Reduction
Added January 4, 2016
1 Communities
1 Members
0 Resources
8 MeSH Terms
Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.
Timmel MA, Byl JA, Osheroff N
(2013) Chem Res Toxicol 26: 622-8
MeSH Terms: Antigens, Neoplasm, Camellia sinensis, Catechin, DNA Cleavage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Humans, Saccharomyces cerevisiae, Tea
Added March 7, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Anthracyclines and heart failure.
Sawyer DB
(2013) N Engl J Med 368: 1154-6
MeSH Terms: Animals, Anthracyclines, DNA Breaks, Double-Stranded, DNA Topoisomerases, Type II, DNA-Binding Proteins, Heart Failure, Humans, Mice, Reactive Oxygen Species
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms