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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 216

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MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
Vilgelm AE, Saleh N, Shattuck-Brandt R, Riemenschneider K, Slesur L, Chen SC, Johnson CA, Yang J, Blevins A, Yan C, Johnson DB, Al-Rohil RN, Halilovic E, Kauffmann RM, Kelley M, Ayers GD, Richmond A
(2019) Sci Transl Med 11:
MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Cell Cycle, Cell Survival, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase Inhibitor p21, DNA Replication, Dimethyl Sulfoxide, Humans, Immunoprecipitation, MCF-7 Cells, Melanoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Proteomics, Proto-Oncogene Proteins c-mdm2, Radioimmunoprecipitation Assay
Added September 27, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.
Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK
(2019) Open Biol 9: 190117
MeSH Terms: Animals, Cell Survival, DNA Replication, DNA-Binding Proteins, Drug Discovery, Enzyme Inhibitors, Gene Expression, High-Throughput Nucleotide Sequencing, Humans, Kinetics, Minichromosome Maintenance Proteins, Molecular Structure, Protein Binding, Suramin, Xenopus
Added August 26, 2019
0 Communities
2 Members
0 Resources
15 MeSH Terms
Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link.
Thompson PS, Amidon KM, Mohni KN, Cortez D, Eichman BF
(2019) Nat Struct Mol Biol 26: 613-618
MeSH Terms: Crystallography, X-Ray, DNA Repair, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Escherichia coli, Escherichia coli Proteins, Humans, Molecular Docking Simulation, Protein Conformation, Thiazolidines
Added August 26, 2019
0 Communities
1 Members
0 Resources
11 MeSH Terms
The abundant DNA adduct -methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase η.
Njuma OJ, Su Y, Guengerich FP
(2019) J Biol Chem 294: 10253-10265
MeSH Terms: DNA Adducts, DNA Damage, DNA Repair, DNA Replication, DNA-Directed DNA Polymerase, Deoxyguanosine, Humans, Molecular Structure
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Human DNA polymerase η has reverse transcriptase activity in cellular environments.
Su Y, Ghodke PP, Egli M, Li L, Wang Y, Guengerich FP
(2019) J Biol Chem 294: 6073-6081
MeSH Terms: Cell Line, Crystallography, X-Ray, DNA Primers, DNA Replication, DNA-Directed DNA Polymerase, Humans, RNA-Directed DNA Polymerase, Reverse Transcription
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA.
Mohni KN, Wessel SR, Zhao R, Wojciechowski AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, Cortez D
(2019) Cell 176: 144-153.e13
MeSH Terms: 5-Methylcytosine, Apurinic Acid, DNA, DNA Damage, DNA Repair, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Endonucleases, Escherichia coli, Polynucleotides, Proliferating Cell Nuclear Antigen
Added August 26, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms
Movement of the RecG Motor Domain upon DNA Binding Is Required for Efficient Fork Reversal.
Warren GM, Stein RA, Mchaourab HS, Eichman BF
(2018) Int J Mol Sci 19:
MeSH Terms: DNA, DNA Helicases, DNA Replication, DNA-Binding Proteins, Models, Molecular, Molecular Conformation, Mutation, Nucleic Acid Conformation, Protein Binding, Protein Interaction Domains and Motifs, Structure-Activity Relationship
Added August 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila.
Munden A, Rong Z, Sun A, Gangula R, Mallal S, Nordman JT
(2018) Elife 7:
MeSH Terms: Amino Acid Sequence, Animals, Carrier Proteins, DNA, DNA Replication, DNA-Binding Proteins, Drosophila Proteins, Drosophila melanogaster, Gene Dosage, Genome, Insect, Heat-Shock Response, Heterochromatin, Mutation, Protein Binding, Protein Domains, Reproducibility of Results, Salivary Glands
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression.
Chavez DA, Greer BH, Eichman BF
(2018) J Biol Chem 293: 8484-8494
MeSH Terms: DNA Helicases, DNA Replication, DNA, Single-Stranded, DNA-Binding Proteins, Humans, Protein Domains, Transcription Factors
Added August 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
MDM2 Antagonists Counteract Drug-Induced DNA Damage.
Vilgelm AE, Cobb P, Malikayil K, Flaherty D, Andrew Johnson C, Raman D, Saleh N, Higgins B, Vara BA, Johnston JN, Johnson DB, Kelley MC, Chen SC, Ayers GD, Richmond A
(2017) EBioMedicine 24: 43-55
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Azepines, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, DNA Damage, DNA Replication, HCT116 Cells, Humans, Imidazoles, Melanoma, Mice, Piperazines, Protein Binding, Proto-Oncogene Proteins c-mdm2, Pyrimidines, Pyrrolidines, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays, para-Aminobenzoates
Added June 20, 2018
1 Communities
2 Members
0 Resources
MeSH Terms