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Results: 1 to 10 of 18

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Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates.
Sugitani N, Voehler MW, Roh MS, Topolska-Woś AM, Chazin WJ
(2017) J Biol Chem 292: 16847-16857
MeSH Terms: Amino Acid Substitution, DNA Repair, DNA Repair Enzymes, DNA, Single-Stranded, Humans, Mutation, Missense, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Structural Homology, Protein, Xeroderma Pigmentosum, Xeroderma Pigmentosum Group A Protein
Added March 24, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Preface.
Eichman BF
(2017) Methods Enzymol 592: xvii-xx
MeSH Terms: Animals, Biochemistry, DNA, DNA Damage, DNA Repair, DNA Repair Enzymes, Humans
Added August 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Preface.
Eichman BF
(2017) Methods Enzymol 591: xv-xviii
MeSH Terms: DNA Damage, DNA Repair, DNA Repair Enzymes, Methods
Added August 26, 2019
0 Communities
1 Members
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MeSH Terms
The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.
Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D
(2015) Mol Cell 59: 998-1010
MeSH Terms: Ataxia Telangiectasia Mutated Proteins, Cell Line, Tumor, DNA Damage, DNA Helicases, DNA Repair Enzymes, DNA Replication, DNA-Directed DNA Polymerase, Deoxyribonucleases, Enzyme Stability, HEK293 Cells, Humans, S Phase Cell Cycle Checkpoints, Transcription Factors
Added February 4, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo.
Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, Essigmann JM
(2015) Nucleic Acids Res 43: 5489-500
MeSH Terms: DNA Adducts, DNA Damage, DNA Polymerase beta, DNA Repair, DNA Repair Enzymes, Dioxygenases, Guanine, High-Throughput Nucleotide Sequencing, Mutagenesis, Mutation, Sequence Analysis, DNA, Sequence Deletion
Added January 7, 2016
0 Communities
3 Members
0 Resources
12 MeSH Terms
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins.
Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B
(2015) DNA Repair (Amst) 30: 1-10
MeSH Terms: Adenine, AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase, AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase, Bacteria, Bacterial Proteins, Cytosine, DNA, DNA Adducts, DNA Glycosylases, DNA Repair, DNA Repair Enzymes, DNA, Single-Stranded, Dioxygenases, Escherichia coli, Escherichia coli Proteins, Guanine, Humans, Mixed Function Oxygenases, Mycobacterium tuberculosis, Rhizobium etli, Streptomyces, Substrate Specificity, Xanthomonas campestris
Added January 7, 2016
0 Communities
2 Members
0 Resources
23 MeSH Terms
Mdmx promotes genomic instability independent of p53 and Mdm2.
Carrillo AM, Bouska A, Arrate MP, Eischen CM
(2015) Oncogene 34: 846-56
MeSH Terms: ATP-Binding Cassette Transporters, Acid Anhydride Hydrolases, Animals, Cell Cycle Proteins, DNA Damage, DNA Repair, DNA Repair Enzymes, DNA-Binding Proteins, Genomic Instability, Humans, MRE11 Homologue Protein, Mice, Mice, Knockout, Neoplasms, Nuclear Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-mdm2, Signal Transduction, Tumor Suppressor Protein p53
Added March 17, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Xeroderma pigmentosum complementation group C protein (XPC) serves as a general sensor of damaged DNA.
Shell SM, Hawkins EK, Tsai MS, Hlaing AS, Rizzo CJ, Chazin WJ
(2013) DNA Repair (Amst) 12: 947-53
MeSH Terms: Animals, Base Sequence, Binding Sites, DNA, DNA Damage, DNA Repair, DNA Repair Enzymes, DNA-Binding Proteins, Fluorescence Polarization, High-Throughput Screening Assays, Humans, Sf9 Cells, Spodoptera
Added March 7, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome.
Wang Z, Sun Y, Gao B, Lu Y, Fang R, Gao Y, Xiao T, Liu XY, Pao W, Zhao Y, Chen H, Ji H
(2014) Cancer Lett 342: 36-42
MeSH Terms: Adenocarcinoma, Adenosine Triphosphatases, Adult, Animals, Animals, Genetically Modified, Base Sequence, Carcinogenesis, Cell Line, DNA Mutational Analysis, DNA Repair Enzymes, DNA-Binding Proteins, Drosophila, Female, Genetic Association Studies, Genetic Predisposition to Disease, Germ-Line Mutation, Humans, Lung Neoplasms, Male, Mice, Middle Aged, Mismatch Repair Endonuclease PMS2, Mutation, Missense, Neoplastic Syndromes, Hereditary, Pedigree, Radiography, Tumor Suppressor Protein p53, Young Adult
Added September 3, 2013
0 Communities
2 Members
0 Resources
28 MeSH Terms
MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers.
Vilar E, Bartnik CM, Stenzel SL, Raskin L, Ahn J, Moreno V, Mukherjee B, Iniesta MD, Morgan MA, Rennert G, Gruber SB
(2011) Cancer Res 71: 2632-42
MeSH Terms: Acid Anhydride Hydrolases, Benzimidazoles, Cell Line, Tumor, Colorectal Neoplasms, DNA Damage, DNA Repair Enzymes, DNA-Binding Proteins, Enzyme Inhibitors, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Humans, MRE11 Homologue Protein, Microsatellite Instability, Mutation, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases, Rad51 Recombinase, Recombination, Genetic
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms