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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling.
Ahmad R, Kumar B, Chen Z, Chen X, Müller D, Lele SM, Washington MK, Batra SK, Dhawan P, Singh AB
(2017) Oncogene 36: 6592-6604
MeSH Terms: Adenocarcinoma, Animals, Carcinogenesis, Cell Transformation, Neoplastic, Claudin-3, Colon, Colonic Neoplasms, Colorectal Neoplasms, Cytokine Receptor gp130, Epigenesis, Genetic, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Humans, Intestinal Mucosa, Mice, Mice, Knockout, Permeability, STAT3 Transcription Factor, Up-Regulation, Wnt Signaling Pathway, beta Catenin
Added March 14, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass.
Walker EC, Johnson RW, Hu Y, Brennan HJ, Poulton IJ, Zhang JG, Jenkins BJ, Smyth GK, Nicola NA, Sims NA
(2016) J Biol Chem 291: 21703-21716
MeSH Terms: Animals, Bone Diseases, Metabolic, Bone and Bones, Cytokine Receptor gp130, Disease Models, Animal, Humans, Leukemia Inhibitory Factor Receptor alpha Subunit, Mice, Oncostatin M, Oncostatin M Receptor beta Subunit, Organ Size, Osteocytes, Phosphorylation, STAT1 Transcription Factor, STAT3 Transcription Factor
Added March 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone.
Johnson RW, McGregor NE, Brennan HJ, Crimeen-Irwin B, Poulton IJ, Martin TJ, Sims NA
(2015) Bone 81: 343-351
MeSH Terms: Animals, Bone Marrow, Bone Marrow Cells, Bone and Bones, Cartilage, Cathepsin K, Cytokine Receptor gp130, Female, Femur, Gene Deletion, Interleukin-6, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Osteoclasts, Osteogenesis, Real-Time Polymerase Chain Reaction, Receptors, Interleukin-11, Receptors, Interleukin-6, Sex Factors, Signal Transduction, X-Ray Microtomography
Added March 26, 2019
0 Communities
1 Members
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MeSH Terms
Loss of the polarity protein PAR3 activates STAT3 signaling via an atypical protein kinase C (aPKC)/NF-κB/interleukin-6 (IL-6) axis in mouse mammary cells.
Guyer RA, Macara IG
(2015) J Biol Chem 290: 8457-68
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Autocrine Communication, Cell Adhesion Molecules, Cell Cycle Proteins, Cells, Cultured, Cytokine Receptor gp130, Enzyme Activation, Epithelial Cells, Female, Interleukin-6, Mammary Glands, Animal, Mice, Inbred C3H, NF-kappa B, Phosphorylation, Protein Kinase C, Protein Processing, Post-Translational, STAT3 Transcription Factor, Signal Transduction
Added April 10, 2018
0 Communities
1 Members
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19 MeSH Terms
gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation.
Standal T, Johnson RW, McGregor NE, Poulton IJ, Ho PW, Martin TJ, Sims NA
(2014) J Endocrinol 223: 181-90
MeSH Terms: Animals, Animals, Newborn, Cell Differentiation, Cells, Cultured, Cytokine Receptor gp130, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Osteoblasts, Osteocytes, Osteogenesis, Parathyroid Hormone, Receptor, Parathyroid Hormone, Type 1
Added March 26, 2019
0 Communities
1 Members
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MeSH Terms
SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation.
Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR
(2014) Exp Neurol 254: 180-9
MeSH Terms: Animals, Astrocytes, Benzoxazoles, Central Nervous System Stimulants, Corpus Striatum, Cytokine Receptor gp130, Dopaminergic Neurons, Drug Interactions, Fever, Glial Fibrillary Acidic Protein, Gliosis, Male, Methamphetamine, Mice, Oncostatin M Receptor beta Subunit, Phosphorylation, Piperazines, Receptors, sigma, STAT3 Transcription Factor, Signal Transduction
Added August 26, 2015
0 Communities
1 Members
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20 MeSH Terms
The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation.
Johnson RW, Brennan HJ, Vrahnas C, Poulton IJ, McGregor NE, Standal T, Walker EC, Koh TT, Nguyen H, Walsh NC, Forwood MR, Martin TJ, Sims NA
(2014) J Bone Miner Res 29: 1492-505
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Bone and Bones, Cell Count, Cell Lineage, Collagen Type I, Cytokine Receptor gp130, Female, Gene Deletion, Gene Knockdown Techniques, Glycoproteins, Integrases, Intercellular Signaling Peptides and Proteins, Male, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Organ Size, Osteoblasts, Osteocalcin, Osteoclasts, Osteocytes, Osteogenesis, Reproducibility of Results, Signal Transduction, Sp7 Transcription Factor, Transcription Factors
Added March 26, 2019
0 Communities
1 Members
0 Resources
27 MeSH Terms
Leukemia inhibitory factor: a paracrine mediator of bone metabolism.
Sims NA, Johnson RW
(2012) Growth Factors 30: 76-87
MeSH Terms: Animals, Bone Diseases, Bone and Bones, Chondrocytes, Cytokine Receptor gp130, Gene Expression Regulation, Humans, Inflammation, Leukemia Inhibitory Factor, Leukemia Inhibitory Factor Receptor alpha Subunit, Mice, Osteoblasts, Osteogenesis
Added March 26, 2019
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MeSH Terms
Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth.
Wang H, Lathia JD, Wu Q, Wang J, Li Z, Heddleston JM, Eyler CE, Elderbroom J, Gallagher J, Schuschu J, MacSwords J, Cao Y, McLendon RE, Wang XF, Hjelmeland AB, Rich JN
(2009) Stem Cells 27: 2393-404
MeSH Terms: Animals, Apoptosis, Brain Neoplasms, Cell Proliferation, Cell Survival, Cytokine Receptor gp130, Glioma, Graft Survival, Growth Inhibitors, Humans, Interleukin-6, Mice, Mice, Nude, Neoplastic Stem Cells, RNA Interference, RNA, Small Interfering, Receptors, Interleukin-6, STAT3 Transcription Factor, Signal Transduction, Transplantation, Heterologous, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo.
Bronte-Tinkew DM, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, Sasakawa C, Ropeleski MJ, Peek RM, Jones NL
(2009) Cancer Res 69: 632-9
MeSH Terms: Adenocarcinoma, Animals, Antigens, Bacterial, Bacterial Proteins, Cell Line, Tumor, Cell Nucleus, Cytokine Receptor gp130, Gerbillinae, HeLa Cells, Helicobacter Infections, Helicobacter pylori, Humans, Male, Phosphorylation, Receptors, Interleukin-6, STAT3 Transcription Factor, Stomach Neoplasms, Transcription, Genetic, Tyrosine
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms