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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 20

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Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
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23 MeSH Terms
Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.
Wang C, Pallan PS, Zhang W, Lei L, Yoshimoto FK, Waterman MR, Egli M, Guengerich FP
(2017) J Biol Chem 292: 10767-10778
MeSH Terms: Adrenal Hyperplasia, Congenital, Circular Dichroism, Cytochromes b5, Deuterium Exchange Measurement, Enzyme Stability, Hot Temperature, Humans, Mutation, Protein Domains, Spectrophotometry, Ultraviolet, Steroid 21-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11.
Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP
(2014) Biochemistry 53: 6161-72
MeSH Terms: Algorithms, Binding, Competitive, Biocatalysis, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Cytochromes b5, Deuterium, Electron Transport, Ferric Compounds, Ferrous Compounds, Humans, Hydroxylation, Kinetics, Lauric Acids, Models, Chemical, Models, Molecular, Oxidation-Reduction, Protein Binding, Protein Structure, Tertiary, Substrate Specificity, Tritium
Added January 20, 2015
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1 Members
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21 MeSH Terms
Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase.
Guengerich FP
(2005) Arch Biochem Biophys 440: 204-11
MeSH Terms: Animals, Cytochromes b5, Cytochromes c, Detergents, Electron Transport, Kinetics, Lipids, Microsomes, Liver, NADPH-Ferrihemoprotein Reductase, Osmolar Concentration, Oxidation-Reduction, Phosphatidylcholines, Protein Binding, Rats, Transport Vesicles
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes.
Shimada T, Mernaugh RL, Guengerich FP
(2005) Arch Biochem Biophys 435: 207-16
MeSH Terms: Coenzymes, Cytochrome P-450 Enzyme System, Cytochromes b5, Enzyme Activation, Enzymes, Immobilized, Ferredoxins, Humans, Kinetics, NADH, NADPH Oxidoreductases, NADPH-Ferrihemoprotein Reductase, Protein Binding, Protein Interaction Mapping, Pseudomonas putida, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
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14 MeSH Terms
Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6.
Yun CH, Kim KH, Calcutt MW, Guengerich FP
(2005) J Biol Chem 280: 12279-91
MeSH Terms: 7-Alkoxycoumarin O-Dealkylase, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Binding Sites, Binding, Competitive, Carbon, Catalysis, Chromatography, High Pressure Liquid, Coumarins, Cytochrome P-450 CYP2A6, Cytochromes b5, Electron Transport, Electrons, Humans, Hydrogen, Hydrogen Bonding, Hydroxylation, Kinetics, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mixed Function Oxygenases, Models, Chemical, Oxygen, Protein Binding, Protein Structure, Tertiary, Spectrophotometry, Substrate Specificity, Time Factors, Ultraviolet Rays
Added March 5, 2014
0 Communities
1 Members
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29 MeSH Terms
Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.
Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T
(2002) Protein Expr Purif 24: 329-37
MeSH Terms: Cell Membrane, Cytochrome P-450 Enzyme System, Cytochromes b5, Escherichia coli, Humans, Microsomes, Liver, NADPH-Ferrihemoprotein Reductase, Oxidation-Reduction, Recombinant Proteins, Xenobiotics
Added May 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes.
Yamazaki H, Nakajima M, Nakamura M, Asahi S, Shimada N, Gillam EM, Guengerich FP, Shimada T, Yokoi T
(1999) Drug Metab Dispos 27: 999-1004
MeSH Terms: Anesthetics, Intravenous, Bacteria, Calcium Channel Blockers, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Cytochromes b5, Escherichia coli, Humans, Hydroxylation, In Vitro Techniques, Kinetics, Membranes, Midazolam, Mixed Function Oxygenases, NADPH-Ferrihemoprotein Reductase, Nifedipine, Oxidation-Reduction, Recombinant Proteins, Testosterone
Added May 26, 2014
0 Communities
1 Members
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19 MeSH Terms
Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species.
Brock BJ, Waterman MR
(1999) Biochemistry 38: 1598-606
MeSH Terms: 17-alpha-Hydroxyprogesterone, Animals, Cattle, Cytochromes b5, Enzyme Activation, Enzyme Stability, Heme, Humans, Hydrogen Peroxide, Progesterone, Rats, Recombinant Proteins, Species Specificity, Steroid 17-alpha-Hydroxylase, Steroids, Substrate Specificity
Added February 12, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.
Guengerich FP, Johnson WW
(1997) Biochemistry 36: 14741-50
MeSH Terms: Animals, Chemical Phenomena, Chemistry, Physical, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Cytochromes b5, Electron Transport, Ferric Compounds, Humans, Kinetics, Microsomes, Liver, Mixed Function Oxygenases, Models, Biological, NADPH-Ferrihemoprotein Reductase, Oxidation-Reduction, Rabbits, Recombinant Fusion Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms