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Genetic determinants of variability in warfarin response after the dose-titration phase.
Iwuchukwu OF, Ramirez AH, Shi Y, Bowton EA, Kawai VK, Schildcrout JS, Roden DM, Denny JC, Stein CM
(2016) Pharmacogenet Genomics 26: 510-516
MeSH Terms: Adult, African Americans, Aged, Aged, 80 and over, Anticoagulants, Calcium-Binding Proteins, Carbon-Carbon Ligases, Cytochrome P-450 CYP2C9, Cytochrome P450 Family 4, Epoxide Hydrolases, Female, Humans, International Normalized Ratio, Male, Middle Aged, Pharmacogenomic Variants, Vitamin K Epoxide Reductases, Warfarin, Whites
Added March 14, 2018
0 Communities
2 Members
0 Resources
19 MeSH Terms
Genotype and risk of major bleeding during warfarin treatment.
Kawai VK, Cunningham A, Vear SI, Van Driest SL, Oginni A, Xu H, Jiang M, Li C, Denny JC, Shaffer C, Bowton E, Gage BF, Ray WA, Roden DM, Stein CM
(2014) Pharmacogenomics 15: 1973-83
MeSH Terms: Adult, Aged, Biological Specimen Banks, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Dose-Response Relationship, Drug, Ethnicity, Female, Gene Frequency, Genetic Association Studies, Genetic Variation, Genotype, Hemorrhage, Humans, Male, Middle Aged, Risk Factors, Vitamin K Epoxide Reductases, Warfarin
Added January 23, 2015
0 Communities
4 Members
0 Resources
20 MeSH Terms
Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.
Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A
(2015) J Am Soc Nephrol 26: 597-610
MeSH Terms: Animals, Collagen, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Diabetic Nephropathies, Glomerular Basement Membrane, Hydralazine, Hydrochlorothiazide, Hydroxyeicosatetraenoic Acids, Hypertension, Male, Mice, Knockout, Orchiectomy, Renin-Angiotensin System, Reserpine, Sodium
Added October 27, 2014
2 Communities
4 Members
1 Resources
16 MeSH Terms
Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.
Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE
(2013) Biochemistry 52: 8276-85
MeSH Terms: Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Humans, Hydroxylation, Kinetics, Microsomes, Liver, Vitamin K 2
Added March 7, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record.
Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC
(2012) Pharmacogenomics 13: 407-18
MeSH Terms: Adult, African Americans, Aged, Aged, 80 and over, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Calcium-Binding Proteins, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Dose-Response Relationship, Drug, Drug Administration Schedule, Electronic Health Records, Female, Humans, Male, Middle Aged, Mixed Function Oxygenases, Polymorphism, Single Nucleotide, Substance-Related Disorders, Vitamin K Epoxide Reductases, Warfarin, Whites
Added December 10, 2013
0 Communities
5 Members
0 Resources
23 MeSH Terms
Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.
Gong IY, Schwarz UI, Crown N, Dresser GK, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Wells PS, Kim RB, Tirona RG
(2011) PLoS One 6: e27808
MeSH Terms: Adult, Aged, Aged, 80 and over, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Blood Coagulation, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Dose-Response Relationship, Drug, Female, Gene Frequency, Genotype, Humans, Kidney Function Tests, Male, Middle Aged, Mixed Function Oxygenases, Prospective Studies, Tissue Distribution, Vitamin K, Vitamin K Epoxide Reductases, Warfarin, Young Adult
Added June 26, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function.
Tang Z, Salamanca-Pinzón SG, Wu ZL, Xiao Y, Guengerich FP
(2010) Arch Biochem Biophys 494: 86-93
MeSH Terms: Amino Acid Sequence, Biocatalysis, Biotransformation, Carcinogens, Chromatography, Affinity, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Gas Chromatography-Mass Spectrometry, Humans, Kinetics, Liver, Molecular Sequence Data, Spectrophotometry, Ultraviolet, Substrate Specificity, Tandem Mass Spectrometry
Added March 7, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.
Quigley R, Chakravarty S, Zhao X, Imig JD, Capdevila JH
(2009) Nephron Physiol 113: p23-8
MeSH Terms: Androgens, Animals, Arterioles, Biological Transport, Blood Pressure, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Disease Models, Animal, Hypertension, Kidney Tubules, Proximal, Male, Mice, Mice, Knockout, Sodium, Sodium-Hydrogen Exchanger 3, Sodium-Hydrogen Exchangers
Added August 13, 2010
1 Communities
0 Members
0 Resources
16 MeSH Terms