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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 61

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Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions.
Guengerich FP
(2019) Drug Metab Dispos 47: 1232-1239
MeSH Terms: Computer Simulation, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Ligands
Added March 3, 2020
0 Communities
1 Members
0 Resources
6 MeSH Terms
Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes.
Guengerich FP, Wilkey CJ, Phan TTN
(2019) J Biol Chem 294: 10928-10941
MeSH Terms: Catalysis, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2E1, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Lauric Acids, Ligands, Molecular Conformation, Oxidation-Reduction, Palmitic Acid, Protein Binding, Protein Conformation, Spiro Compounds, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.
Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F
(2015) J Infect Dis 212: 1439-48
MeSH Terms: Animals, Antiprotozoal Agents, Benzamides, Biotransformation, Chagas Disease, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Disease Models, Animal, Female, Humans, Imidazoles, Inhibitory Concentration 50, Leishmaniasis, Visceral, Mice, Mice, Inbred BALB C, Microsomes, Liver, Molecular Structure, Oxadiazoles, Rats, Structure-Activity Relationship, Tissue Distribution, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450.
Bojić M, Sedgeman CA, Nagy LD, Guengerich FP
(2015) Eur J Pharm Sci 73: 49-56
MeSH Terms: Aspirin, Benzaldehydes, Biotransformation, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Deferoxamine, Enzyme Inhibitors, Humans, Hydroxylation, Isoenzymes, Microsomes, Liver, NADP, Organophosphates, Oxidation-Reduction, Reactive Oxygen Species, Recombinant Proteins, Salicylic Acid
Added March 14, 2018
0 Communities
1 Members
0 Resources
17 MeSH Terms
Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
Nguyen L, Robson MJ, Healy JR, Scandinaro AL, Matsumoto RR
(2014) PLoS One 9: e89985
MeSH Terms: Adrenergic alpha-Antagonists, Animals, Antidepressive Agents, Behavior, Animal, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dextromethorphan, Dose-Response Relationship, Drug, Ethylenediamines, Excitatory Amino Acid Antagonists, Ketamine, Kinetics, Male, Mice, Piperazines, Protein Binding, Quinidine, Receptors, N-Methyl-D-Aspartate, Receptors, sigma, Swimming
Added August 26, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.
Manka JT, Rodriguez AL, Morrison RD, Venable DF, Cho HP, Blobaum AL, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA
(2013) Bioorg Med Chem Lett 23: 5091-6
MeSH Terms: Allosteric Regulation, Animals, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dose-Response Relationship, Drug, Enzyme Inhibitors, Humans, Molecular Structure, Pyrroles, Rats, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added February 19, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease.
Dobish MC, Villalta F, Waterman MR, Lepesheva GI, Johnston JN
(2012) Org Lett 14: 6322-5
MeSH Terms: Animals, Chagas Disease, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Imidazoles, Mice, Molecular Structure, Neglected Diseases, Oxadiazoles, Triazoles, Tropical Medicine, Trypanosoma cruzi
Added February 12, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH
(2012) Antimicrob Agents Chemother 56: 4914-21
MeSH Terms: 14-alpha Demethylase Inhibitors, Administration, Oral, Alkyl and Aryl Transferases, Animals, Chagas Disease, Crystallography, X-Ray, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Administration Schedule, Female, Humans, Mice, Models, Molecular, Nitroimidazoles, Quinolones, Structure-Activity Relationship, Triazoles, Trypanocidal Agents, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51).
Lepesheva GI, Villalta F, Waterman MR
(2011) Adv Parasitol 75: 65-87
MeSH Terms: 14-alpha Demethylase Inhibitors, Antifungal Agents, Azoles, Catalytic Domain, Chagas Disease, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Discovery, Humans, Protein Conformation, Substrate Specificity, Triazoles, Trypanocidal Agents, Trypanosoma cruzi
Added February 12, 2015
0 Communities
2 Members
0 Resources
14 MeSH Terms