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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 13

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A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid -1 Hydroxylation Using an Untargeted Metabolomic Approach.
Fekry MI, Xiao Y, Berg JZ, Guengerich FP
(2019) Drug Metab Dispos 47: 1325-1332
MeSH Terms: Animals, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Fatty Acids, Unsaturated, Female, Gastrointestinal Tract, Humans, Hydroxylation, Isotope Labeling, Metabolomics, Rats
Added March 3, 2020
0 Communities
1 Members
0 Resources
11 MeSH Terms
Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.
Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas Ü, Johnson EF, Guengerich FP
(2017) J Biol Chem 292: 11230-11242
MeSH Terms: Animals, Catalysis, Cytochrome P-450 CYP4A, Dithiothreitol, Heme, Humans, Hydrogen Peroxide, Hydroxyeicosatetraenoic Acids, Kidney, Liver, Mice, Mice, Transgenic, Oxidation-Reduction, Rats
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.
Savas Ü, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF
(2016) J Biol Chem 291: 16904-19
MeSH Terms: Angiotensins, Animals, Blood Pressure, Cytochrome P-450 CYP4A, Female, Humans, Hydroxyeicosatetraenoic Acids, Hypertension, Losartan, Male, Mice, Mice, Inbred BALB C, Mice, Transgenic, Receptor, Angiotensin, Type 1, Renin-Angiotensin System, Sodium Chloride, Dietary, Solute Carrier Family 12, Member 3
Added March 14, 2018
0 Communities
2 Members
0 Resources
17 MeSH Terms
Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11.
Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP
(2014) Biochemistry 53: 6161-72
MeSH Terms: Algorithms, Binding, Competitive, Biocatalysis, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Cytochromes b5, Deuterium, Electron Transport, Ferric Compounds, Ferrous Compounds, Humans, Hydroxylation, Kinetics, Lauric Acids, Models, Chemical, Models, Molecular, Oxidation-Reduction, Protein Binding, Protein Structure, Tertiary, Substrate Specificity, Tritium
Added January 20, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans.
Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown NJ
(2014) J Am Soc Hypertens 8: 475-80
MeSH Terms: Adolescent, Adult, African Americans, Aged, Blood Pressure, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, DNA, Double-Blind Method, Female, Genetic Variation, Genotype, Humans, Hypertension, Male, Middle Aged, Mineralocorticoid Receptor Antagonists, Pilot Projects, Radioimmunoassay, United States, Young Adult
Added February 19, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.
Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE
(2013) Biochemistry 52: 8276-85
MeSH Terms: Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Humans, Hydroxylation, Kinetics, Microsomes, Liver, Vitamin K 2
Added March 7, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Association of a CYP4A11 variant and blood pressure in black men.
Gainer JV, Lipkowitz MS, Yu C, Waterman MR, Dawson EP, Capdevila JH, Brown NJ, AASK Study Group
(2008) J Am Soc Nephrol 19: 1606-12
MeSH Terms: Adult, African Americans, Antihypertensive Agents, Blood Pressure, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Disease Progression, Genetic Variation, Genotype, Humans, Hypertension, Male, Middle Aged, Nephrosclerosis, Sex Characteristics
Added December 10, 2013
0 Communities
2 Members
0 Resources
15 MeSH Terms
The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.
Laffer CL, Gainer JV, Waterman MR, Capdevila JH, Laniado-Schwartzman M, Nasjletti A, Brown NJ, Elijovich F
(2008) Hypertension 51: 767-72
MeSH Terms: Adult, Blood Pressure, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Female, Gene Frequency, Genotype, Humans, Hydroxyeicosatetraenoic Acids, Hypertension, Insulin, Insulin Resistance, Male, Middle Aged, Multivariate Analysis, Polymorphism, Single Nucleotide
Added February 12, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases.
Capdevila JH
(2007) Curr Opin Nephrol Hypertens 16: 465-70
MeSH Terms: Animals, Arachidonic Acid, Blood Pressure, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, Eicosapentaenoic Acid, Electrophysiology, Humans, Hydroxyeicosatetraenoic Acids, Hypertension, Ion Transport, Ions, Kidney, Models, Biological, Sodium Channels
Added August 13, 2010
1 Communities
0 Members
0 Resources
15 MeSH Terms
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.
Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH
(2005) Circulation 111: 63-9
MeSH Terms: Adult, African Continental Ancestry Group, Aged, Alleles, Amino Acid Substitution, Arachidonic Acid, Blood Pressure, Codon, Cohort Studies, Comorbidity, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System, DNA Mutational Analysis, European Continental Ancestry Group, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Hydroxyeicosatetraenoic Acids, Hypertension, Introns, Kidney, Lauric Acids, Male, Middle Aged, Multifactorial Inheritance, Mutagenesis, Insertional, Mutation, Missense, Point Mutation, Sequence Deletion, Tennessee, United States
Added December 10, 2013
0 Communities
2 Members
0 Resources
34 MeSH Terms