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Results: 1 to 4 of 4

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High-throughput fluorescence assay of cytochrome P450 3A4.
Cheng Q, Guengerich FP
(2013) Methods Mol Biol 987: 157-62
MeSH Terms: Coumarins, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Enzyme Assays, Humans, Inhibitory Concentration 50, Ketoconazole, Spectrometry, Fluorescence
Added March 26, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Inhibition of human cytochrome P450 3A4 by cholesterol.
Shinkyo R, Guengerich FP
(2011) J Biol Chem 286: 18426-33
MeSH Terms: Anti-Arrhythmia Agents, Cells, Cultured, Cholesterol, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Enzyme Inhibitors, Hepatocytes, Humans, Microsomes, Liver, Models, Biological, Nifedipine, Oxidation-Reduction, Quinidine, Vasodilator Agents
Added March 7, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants.
Akiyoshi T, Saito T, Murase S, Miyazaki M, Murayama N, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H
(2011) Drug Metab Dispos 39: 724-8
MeSH Terms: 14-alpha Demethylase Inhibitors, Androgens, Cimetidine, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Drug Interactions, Enzyme Inhibitors, Genetic Variation, Heme, Humans, Hydroxytestosterones, Itraconazole, Recombinant Proteins, Testosterone
Added March 26, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.
Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2010) Chem Res Toxicol 23: 1921-35
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Binding Sites, Computer Simulation, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Flavonoids, Humans, Kinetics, Structure-Activity Relationship
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms