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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 28

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Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes.
Guengerich FP, Wilkey CJ, Phan TTN
(2019) J Biol Chem 294: 10928-10941
MeSH Terms: Catalysis, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2E1, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Lauric Acids, Ligands, Molecular Conformation, Oxidation-Reduction, Palmitic Acid, Protein Binding, Protein Conformation, Spiro Compounds, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models.
Chattopadhyay M, Chowdhury AR, Feng T, Assenmacher CA, Radaelli E, Guengerich FP, Avadhani NG
(2019) J Biol Chem 294: 10336-10348
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Cytochrome P-450 CYP2D6, Disease Models, Animal, Humans, Male, Methylamines, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Neuroblastoma, Neurons, Neurotoxins, Parkinson Disease, Tumor Cells, Cultured
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
CYP2D6 genotype and adverse events to risperidone in children and adolescents.
Oshikoya KA, Neely KM, Carroll RJ, Aka IT, Maxwell-Horn AC, Roden DM, Van Driest SL
(2019) Pediatr Res 85: 602-606
MeSH Terms: Adolescent, Alleles, Child, Cytochrome P-450 CYP2D6, Electronic Health Records, Female, Genotype, Humans, Male, Pharmacogenetics, Phenotype, Polymorphism, Genetic, Retrospective Studies, Risk, Risperidone, Treatment Outcome
Added March 24, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Goetz MP, Sun JX, Suman VJ, Silva GO, Perou CM, Nakamura Y, Cox NJ, Stephens PJ, Miller VA, Ross JS, Chen D, Safgren SL, Kuffel MJ, Ames MM, Kalari KR, Gomez HL, Gonzalez-Angulo AM, Burgues O, Brauch HB, Ingle JN, Ratain MJ, Yelensky R
(2014) J Natl Cancer Inst 107:
MeSH Terms: Adult, Aged, Antineoplastic Agents, Hormonal, Biomarkers, Tumor, Breast Neoplasms, Cytochrome P-450 CYP2D6, DNA, Neoplasm, Disease-Free Survival, Female, Formaldehyde, Genotype, Humans, Loss of Heterozygosity, Middle Aged, Mouth Mucosa, Paraffin Embedding, Receptor, ErbB-2, Receptors, Estrogen, Survival Analysis, Tamoxifen, Tissue Fixation
Added February 22, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Establishment of CYP2D6 reference samples by multiple validated genotyping platforms.
Fang H, Liu X, Ramírez J, Choudhury N, Kubo M, Im HK, Konkashbaev A, Cox NJ, Ratain MJ, Nakamura Y, O'Donnell PH
(2014) Pharmacogenomics J 14: 564-72
MeSH Terms: Alleles, Cytochrome P-450 CYP2D6, Genetic Variation, Genotype, Genotyping Techniques, Humans, Liver, Microsomes, Liver, Reference Standards, Reproducibility of Results
Added February 22, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
Re: Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA.
Goetz MP, Brauch H, Ratain MJ, Cox NJ, Nakamura Y, Weinshilboum R, Ingle JN
(2014) J Natl Cancer Inst 106:
MeSH Terms: Breast Neoplasms, Cytochrome P-450 CYP2D6, DNA, Neoplasm, Female, Humans
Added February 22, 2016
0 Communities
1 Members
0 Resources
5 MeSH Terms
CYP2D6 genotype and tamoxifen activity: understanding interstudy variability in methodological quality.
Ratain MJ, Nakamura Y, Cox NJ
(2013) Clin Pharmacol Ther 94: 185-7
MeSH Terms: Breast Neoplasms, Cytochrome P-450 CYP2D6, Estrogen Antagonists, Female, Humans, Tamoxifen
Added February 22, 2016
0 Communities
1 Members
0 Resources
6 MeSH Terms
Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records.
Oetjens MT, Denny JC, Ritchie MD, Gillani NB, Richardson DM, Restrepo NA, Pulley JM, Dilks HH, Basford MA, Bowton E, Masys DR, Wilke RA, Roden DM, Crawford DC
(2013) Pharmacogenomics 14: 735-44
MeSH Terms: Adult, Aged, Aged, 80 and over, Cytochrome P-450 CYP2D6, DNA Copy Number Variations, Electronic Health Records, European Continental Ancestry Group, Female, Gene Frequency, Genetic Markers, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Pharmacogenetics, Polymorphism, Single Nucleotide, Polypharmacy, Young Adult
Added December 10, 2013
0 Communities
4 Members
0 Resources
19 MeSH Terms
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG
(2013) J Biol Chem 288: 4436-51
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Adrenergic alpha-Antagonists, Animals, Cell Line, Cytochrome P-450 CYP2D6, Dopamine Agents, Dopaminergic Neurons, Dynamins, Humans, Mice, Mitochondria, Mitochondrial Proteins, Parkinsonian Disorders, Quinidine, Reactive Oxygen Species, Ubiquitin-Protein Ligases
Added March 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.
Nakamura Y, Ratain MJ, Cox NJ, McLeod HL, Kroetz DL, Flockhart DA
(2012) J Natl Cancer Inst 104: 1264; author reply 1266-8
MeSH Terms: Antineoplastic Agents, Hormonal, Breast Neoplasms, Cytochrome P-450 CYP2D6, Female, Glucuronosyltransferase, Humans, Neoplasm Recurrence, Local, Nitriles, Polymorphism, Single Nucleotide, Postmenopause, Tamoxifen, Triazoles
Added February 22, 2016
0 Communities
1 Members
0 Resources
12 MeSH Terms