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is associated with indomethacin treatment failure for patent ductus arteriosus.
Rooney SR, Shelton EL, Aka I, Shaffer CM, Clyman RI, Dagle JM, Ryckman K, Lewis TR, Reese J, Van Driest SL, Kannankeril PJ
(2019) Pharmacogenomics 20: 939-946
MeSH Terms: Cohort Studies, Cyclooxygenase Inhibitors, Cytochrome P-450 CYP2C9, Ductus Arteriosus, Patent, Female, Gestational Age, Humans, Indomethacin, Infant, Infant, Newborn, Infant, Premature, Male, Treatment Failure, Treatment Outcome
Added July 28, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
High and variable population prevalence of HLA-B*56:02 in indigenous Australians and relation to phenytoin-associated drug reaction with eosinophilia and systemic symptoms.
Somogyi AA, Barratt DT, Phillips EJ, Moore K, Ilyas F, Gabb GM
(2019) Br J Clin Pharmacol 85: 2163-2169
MeSH Terms: Adolescent, Adult, Aged, Australia, Biological Variation, Population, Cohort Studies, Cytochrome P-450 CYP2C9, Drug Hypersensitivity Syndrome, Female, Gene Frequency, Genetic Predisposition to Disease, Genotyping Techniques, HLA-B Antigens, Humans, Indigenous Peoples, Male, Middle Aged, Phenytoin, Young Adult
Added March 30, 2020
0 Communities
1 Members
0 Resources
19 MeSH Terms
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.
Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A
(2018) Cancer Res 78: 4865-4877
MeSH Terms: Animals, Arachidonic Acid, Arachidonic Acids, Carcinogenesis, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Eicosanoids, Endothelial Cells, Humans, Mice, Polymorphism, Single Nucleotide, Xenograft Model Antitumor Assays
Added October 25, 2018
0 Communities
2 Members
0 Resources
14 MeSH Terms
Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans.
Hernandez W, Gamazon ER, Aquino-Michaels K, Smithberger E, O'Brien TJ, Harralson AF, Tuck M, Barbour A, Cavallari LH, Perera MA
(2017) J Thromb Haemost 15: 735-743
MeSH Terms: Adult, African Americans, Aged, Algorithms, Calcium-Binding Proteins, Cohort Studies, Cytochrome P-450 CYP2C9, Female, Gene Expression Profiling, Gene Expression Regulation, Genetic Variation, Genotype, Humans, Linkage Disequilibrium, Liver, Male, Middle Aged, Pharmacogenetics, Precision Medicine, Quantitative Trait Loci, Thromboembolism, Vitamin K Epoxide Reductases, Warfarin
Added April 13, 2017
0 Communities
1 Members
0 Resources
23 MeSH Terms
STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION.
Wiley LK, Vanhouten JP, Samuels DC, Aldrich MC, Roden DM, Peterson JF, Denny JC
(2017) Pac Symp Biocomput 22: 545-556
MeSH Terms: Adult, African Americans, Aged, Algorithms, Anticoagulants, Cohort Studies, Computational Biology, Cytochrome P-450 CYP2C9, European Continental Ancestry Group, Female, Gene Frequency, Humans, Male, Middle Aged, Models, Genetic, Pharmacogenomic Variants, Polymorphism, Single Nucleotide, Vitamin K Epoxide Reductases, Warfarin
Added March 14, 2018
0 Communities
2 Members
0 Resources
19 MeSH Terms
Genetic determinants of variability in warfarin response after the dose-titration phase.
Iwuchukwu OF, Ramirez AH, Shi Y, Bowton EA, Kawai VK, Schildcrout JS, Roden DM, Denny JC, Stein CM
(2016) Pharmacogenet Genomics 26: 510-516
MeSH Terms: Adult, African Americans, Aged, Aged, 80 and over, Anticoagulants, Calcium-Binding Proteins, Carbon-Carbon Ligases, Cytochrome P-450 CYP2C9, Cytochrome P450 Family 4, Epoxide Hydrolases, European Continental Ancestry Group, Female, Humans, International Normalized Ratio, Male, Middle Aged, Pharmacogenomic Variants, Vitamin K Epoxide Reductases, Warfarin
Added March 14, 2018
0 Communities
2 Members
0 Resources
19 MeSH Terms
Dynamics of CYP51: implications for function and inhibitor design.
Yu X, Cojocaru V, Mustafa G, Salo-Ahen OM, Lepesheva GI, Wade RC
(2015) J Mol Recognit 28: 59-73
MeSH Terms: Catalytic Domain, Crystallography, X-Ray, Cytochrome P-450 CYP2C9, Drug Design, Humans, Hydrogen Bonding, Molecular Dynamics Simulation, Protein Structure, Secondary, Protozoan Proteins, Solvents, Sterol 14-Demethylase, Substrate Specificity, Trypanosoma brucei brucei
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Genotype and risk of major bleeding during warfarin treatment.
Kawai VK, Cunningham A, Vear SI, Van Driest SL, Oginni A, Xu H, Jiang M, Li C, Denny JC, Shaffer C, Bowton E, Gage BF, Ray WA, Roden DM, Stein CM
(2014) Pharmacogenomics 15: 1973-83
MeSH Terms: Adult, Aged, Biological Specimen Banks, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Dose-Response Relationship, Drug, Ethnic Groups, Female, Gene Frequency, Genetic Association Studies, Genetic Variation, Genotype, Hemorrhage, Humans, Male, Middle Aged, Risk Factors, Vitamin K Epoxide Reductases, Warfarin
Added January 23, 2015
0 Communities
4 Members
0 Resources
20 MeSH Terms
The role of cytochrome P450 epoxygenases in retinal angiogenesis.
Capozzi ME, McCollum GW, Penn JS
(2014) Invest Ophthalmol Vis Sci 55: 4253-60
MeSH Terms: Animals, Animals, Newborn, Aryl Hydrocarbon Hydroxylases, Astrocytes, Cell Proliferation, Cells, Cultured, Cytochrome P-450 CYP2C8, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme System, Disease Models, Animal, Endothelium, Vascular, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression Regulation, Developmental, Humans, Microcirculation, RNA, Messenger, Rats, Rats, Sprague-Dawley, Real-Time Polymerase Chain Reaction, Retina, Retinal Neovascularization, Vascular Endothelial Growth Factor A
Added February 19, 2015
1 Communities
1 Members
0 Resources
24 MeSH Terms
The impact of age and CYP2C9 and VKORC1 variants on stable warfarin dose in the paediatric population.
Vear SI, Ayers GD, Van Driest SL, Sidonio RF, Stein CM, Ho RH
(2014) Br J Haematol 165: 832-5
MeSH Terms: Adolescent, Age Factors, Alleles, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Child, Child, Preschool, Cross-Sectional Studies, Cytochrome P-450 CYP2C9, Genetic Variation, Genotype, Humans, Infant, Pharmacogenetics, Retrospective Studies, Vitamin K Epoxide Reductases, Warfarin
Added March 10, 2014
1 Communities
3 Members
0 Resources
17 MeSH Terms