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Results: 1 to 10 of 21

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Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.
Mollan KR, Tierney C, Hellwege JN, Eron JJ, Hudgens MG, Gulick RM, Haubrich R, Sax PE, Campbell TB, Daar ES, Robertson KR, Ventura D, Ma Q, Edwards DRV, Haas DW, AIDS Clinical Trials Group
(2017) J Infect Dis 216: 554-564
MeSH Terms: Adult, Alkynes, Anti-HIV Agents, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2A6, Cytochrome P-450 CYP2B6, Ethnicity, Female, Gene Frequency, Genotype, HIV Infections, Humans, Male, Pharmacogenetics, Polymorphism, Single Nucleotide, Proportional Hazards Models, Racial Groups, Risk Factors, Suicidal Ideation, Suicide, Treatment Outcome
Added March 3, 2020
0 Communities
1 Members
0 Resources
22 MeSH Terms
Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.
Luetkemeyer AF, Rosenkranz SL, Lu D, Grinsztejn B, Sanchez J, Ssemmanda M, Sanne I, McIlleron H, Havlir DV, Haas DW, Adult AIDS Clinical Trials Group A5221 and A5243 Study Teams
(2015) Clin Infect Dis 60: 1860-3
MeSH Terms: Alkynes, Antitubercular Agents, Arylamine N-Acetyltransferase, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Genotype, HIV Infections, Humans, Male, Peru, Pharmacogenetics, Rifampin, South Africa, Tuberculosis, Uganda
Added March 13, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa.
Sinxadi PZ, Leger PD, McIlleron HM, Smith PJ, Dave JA, Levitt NS, Maartens G, Haas DW
(2015) Br J Clin Pharmacol 80: 146-56
MeSH Terms: Adolescent, Adult, Alkynes, Anti-HIV Agents, Benzoxazines, Blacks, Child, Child, Preschool, Constitutive Androstane Receptor, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Genotype, HIV Infections, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, South Africa, Young Adult
Added March 13, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes.
Haas DW, Kwara A, Richardson DM, Baker P, Papageorgiou I, Acosta EP, Morse GD, Court MH
(2014) J Antimicrob Chemother 69: 2175-82
MeSH Terms: Adult, Alkynes, Anti-HIV Agents, Benzoxazines, Blacks, Cyclopropanes, Cytochrome P-450 CYP2A6, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP2B6 Inducers, Female, Gene Dosage, Glucuronosyltransferase, HIV Infections, HIV-1, Humans, Male, Polymorphism, Single Nucleotide, Prospective Studies, Reverse Transcriptase Inhibitors, Secondary Metabolism, Whites
Added March 13, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Functional CYP2B6 variants and virologic response to an efavirenz-containing regimen in Port-au-Prince, Haiti.
Haas DW, Severe P, Jean Juste MA, Pape JW, Fitzgerald DW
(2014) J Antimicrob Chemother 69: 2187-90
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Adult, Alkynes, Anti-HIV Agents, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2A6, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP3A, Female, Genetic Association Studies, HIV Infections, HIV-1, Haiti, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, RNA, Viral, Reverse Transcriptase Inhibitors, Secondary Metabolism, Treatment Outcome
Added March 13, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.
Murayama N, van Beuningen R, Suemizu H, Guillouzo CG, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H
(2014) Chem Res Toxicol 27: 304-308
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biotransformation, Cell Line, Cells, Cultured, Constitutive Androstane Receptor, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP3A, Hepatocytes, Humans, Pregnane X Receptor, Protein Array Analysis, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, Thalidomide
Added March 10, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype.
McIlleron HM, Schomaker M, Ren Y, Sinxadi P, Nuttall JJ, Gous H, Moultrie H, Eley B, Merry C, Smith P, Haas DW, Maartens G
(2013) AIDS 27: 1933-40
MeSH Terms: Alkynes, Anti-HIV Agents, Antitubercular Agents, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Child, Child, Preschool, Cyclopropanes, Cytochrome P-450 CYP2B6, Drug Interactions, Female, Genotype, HIV Infections, Humans, Male, Plasma, Rifampin, Tuberculosis
Added March 13, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission.
Vardhanabhuti S, Acosta EP, Ribaudo HJ, Severe P, Lalloo U, Kumarasamy N, Taulo F, Kabanda J, Oneko O, Ive P, Sambarey P, Chan ES, Hitti J, Hong F, McMahon D, Haas DW, A5207 ACTG Study Team
(2013) J Infect Dis 208: 662-71
MeSH Terms: Adult, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Chemoprevention, Cytochrome P-450 CYP2B6, Female, HIV Infections, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Inhibitory Concentration 50, Male, Metabolic Clearance Rate, Nevirapine, Oxidoreductases, N-Demethylating, Plasma, Polymorphism, Genetic, Pregnancy, Time Factors, Young Adult
Added March 13, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Pharmacokinetics of phase I nevirapine metabolites following a single dose and at steady state.
Fan-Havard P, Liu Z, Chou M, Ling Y, Barrail-Tran A, Haas DW, Taburet AM, ANRS12154 Study Group
(2013) Antimicrob Agents Chemother 57: 2154-60
MeSH Terms: Adult, African Americans, Anti-HIV Agents, Area Under Curve, Aryl Hydrocarbon Hydroxylases, Asians, Biotransformation, Case-Control Studies, Chromatography, Liquid, Cytochrome P-450 CYP2B6, Drug Administration Schedule, Female, HIV Infections, HIV-1, Humans, Male, Nevirapine, Oxidoreductases, N-Demethylating, Polymorphism, Genetic, Tandem Mass Spectrometry
Added March 13, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa.
Phillips E, Bartlett JA, Sanne I, Lederman MM, Hinkle J, Rousseau F, Dunn D, Pavlos R, James I, Mallal SA, Haas DW
(2013) J Acquir Immune Defic Syndr 62: e55-7
MeSH Terms: Adult, Alanine Transaminase, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Aspartate Aminotransferases, Chemical and Drug Induced Liver Injury, Cytochrome P-450 CYP2B6, Double-Blind Method, Female, Genotype, HIV Infections, HLA-B Antigens, HLA-DRB1 Chains, Humans, Male, Multivariate Analysis, Nevirapine, Oxidoreductases, N-Demethylating, Phenotype, Reverse Transcriptase Inhibitors, South Africa
Added March 13, 2015
0 Communities
2 Members
0 Resources
21 MeSH Terms