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Results: 1 to 10 of 12

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Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
Chaugai S, Dickson AL, Shuey MM, Feng Q, Barker KA, Wei WQ, Luther JM, Stein CM, Chung CP
(2019) Clin Pharmacol Ther 105: 703-709
MeSH Terms: Adult, Clonidine, Cohort Studies, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Drug Therapy, Combination, Female, Humans, Hypotension, Male, Middle Aged, Muscle Relaxants, Central, Polypharmacy, Retrospective Studies, Risk Factors
Added October 25, 2018
0 Communities
1 Members
0 Resources
15 MeSH Terms
Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds.
Shimada T, Murayama N, Tanaka K, Takenaka S, Guengerich FP, Yamazaki H, Komori M
(2011) Chem Res Toxicol 24: 1327-37
MeSH Terms: Animals, Antineoplastic Agents, Aryl Hydrocarbon Hydroxylases, Binding Sites, Biocatalysis, Catalytic Domain, Computer Simulation, Cyanates, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2A6, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Neoplasms, Organoselenium Compounds, Protein Binding, Rats
Added March 26, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.
Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2010) Chem Res Toxicol 23: 1921-35
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Binding Sites, Computer Simulation, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Flavonoids, Humans, Kinetics, Structure-Activity Relationship
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli.
Kim DH, Kim KH, Isin EM, Guengerich FP, Chae HZ, Ahn T, Yun CH
(2008) Protein Expr Purif 57: 188-200
MeSH Terms: Amino Acid Sequence, Base Sequence, Codon, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Deuterium, Enzyme Inhibitors, Escherichia coli, Humans, Hydrogen Peroxide, Hydroxylation, Kinetics, Molecular Sequence Data, Mutation, NADP, Oxidation-Reduction, Spectrophotometry, Substrate Specificity, Temperature
Added March 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.
Shimada T, Murayama N, Okada K, Funae Y, Yamazaki H, Guengerich FP
(2007) Chem Res Toxicol 20: 489-96
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Catalysis, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Enzyme Inhibitors, Humans, Kinetics, Oxazines, Polycyclic Aromatic Hydrocarbons
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons.
Shimada T, Guengerich FP
(2006) Chem Res Toxicol 19: 288-94
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Carcinogens, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Enzyme Activation, Enzyme Inhibitors, Humans, Molecular Structure, Polycyclic Aromatic Hydrocarbons, Salmonella typhimurium, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
Ueng YF, Jan WC, Lin LC, Chen TL, Guengerich FP, Chen CF
(2002) Drug Metab Dispos 30: 349-53
MeSH Terms: Alkaloids, Animals, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Humans, In Vitro Techniques, Indole Alkaloids, Kinetics, Magnetic Resonance Spectroscopy, Mice, Mice, Inbred C57BL, Microsomes, Liver, Oxidoreductases, Plant Extracts, Quinazolines, Structure-Activity Relationship, Substrate Specificity, Theophylline
Added May 26, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2.
Turesky RJ, Parisod V, Huynh-Ba T, Langouët S, Guengerich FP
(2001) Chem Res Toxicol 14: 901-11
MeSH Terms: Amines, Animals, Biotransformation, Cells, Cultured, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Enzyme Inhibitors, Hepatocytes, Humans, Inactivation, Metabolic, Kinetics, Microsomes, Liver, Mutagens, NADPH-Ferrihemoprotein Reductase, Quinoxalines, Rats, Recombinant Proteins, Species Specificity, Substrate Specificity, Theophylline
Added May 26, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2.
Langouët S, Welti DH, Kerriguy N, Fay LB, Huynh-Ba T, Markovic J, Guengerich FP, Guillouzo A, Turesky RJ
(2001) Chem Res Toxicol 14: 211-21
MeSH Terms: Animals, Biotransformation, Cell Separation, Cells, Cultured, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Enzyme Inhibitors, Hepatocytes, Humans, In Vitro Techniques, Inactivation, Metabolic, Magnetic Resonance Spectroscopy, Mass Spectrometry, Microsomes, Liver, Mutagens, Quinoxalines, Rats, Theophylline
Added May 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.
Langouët S, Furge LL, Kerriguy N, Nakamura K, Guillouzo A, Guengerich FP
(2000) Chem Res Toxicol 13: 245-52
MeSH Terms: Anticarcinogenic Agents, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Humans, Isothiocyanates, Pyrazines, Quinolines, Sulfoxides, Thiocyanates, Thiones, Thiophenes
Added May 26, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms