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Results: 1 to 10 of 42

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Development and Uses of Offline and Web-Searchable Metabolism Databases - The Case of Benzo[a]pyrene.
Rendic SP, Guengerich FP
(2018) Curr Drug Metab 19: 3-46
MeSH Terms: Animals, Benzo(a)pyrene, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, Databases, Factual, Humans
Added March 14, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms
Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13.
Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2016) Xenobiotica 46: 211-24
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP2A6, Humans, Lepidoptera, Models, Biological, Molecular Docking Simulation, Oxidation-Reduction, Polycyclic Compounds, Pyrenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection.
Sudenga SL, Shrestha S, Macaluso M, Partridge EE, Johanning GL, Piyathilake CJ
(2014) Gynecol Oncol 135: 560-4
MeSH Terms: Adult, Cohort Studies, Cytochrome P-450 CYP1A1, DNA, Viral, Female, Genotype, Glutathione Transferase, Humans, Papillomaviridae, Papillomavirus Infections, Uterine Cervical Diseases, Uterine Cervical Neoplasms
Added August 15, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Targeted multiplex imaging mass spectrometry with single chain fragment variable (scfv) recombinant antibodies.
Thiery G, Mernaugh RL, Yan H, Spraggins JM, Yang J, Parl FF, Caprioli RM
(2012) J Am Soc Mass Spectrom 23: 1689-96
MeSH Terms: Animals, Antibodies, Monoclonal, Aryl Hydrocarbon Hydroxylases, Avidin, Biotin, Breast, Breast Neoplasms, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, Enzyme-Linked Immunosorbent Assay, Female, Histocytochemistry, Humans, Mass Spectrometry, Mice, Molecular Imaging, Rats, Recombinant Proteins, Sensitivity and Specificity, Single-Chain Antibodies
Added March 7, 2014
1 Communities
2 Members
0 Resources
20 MeSH Terms
Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1.
Wang K, Guengerich FP
(2012) Chem Res Toxicol 25: 1740-51
MeSH Terms: Antineoplastic Agents, Benzothiazoles, Biocatalysis, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP1A1, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 2, DNA Adducts, Humans, Kinetics, Microsomes, Liver, Oxidation-Reduction, Spectrometry, Mass, Electrospray Ionization, Thiazoles
Added March 7, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds.
Shimada T, Murayama N, Tanaka K, Takenaka S, Guengerich FP, Yamazaki H, Komori M
(2011) Chem Res Toxicol 24: 1327-37
MeSH Terms: Animals, Antineoplastic Agents, Aryl Hydrocarbon Hydroxylases, Binding Sites, Biocatalysis, Catalytic Domain, Computer Simulation, Cyanates, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2A6, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Neoplasms, Organoselenium Compounds, Protein Binding, Rats
Added March 26, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction.
Crooke PS, Justenhoven C, Brauch H, GENICA Consortium, Dawling S, Roodi N, Higginbotham KS, Plummer WD, Schuyler PA, Sanders ME, Page DL, Smith JR, Dupont WD, Parl FF
(2011) Cancer Epidemiol Biomarkers Prev 20: 1502-15
MeSH Terms: Adult, Algorithms, Area Under Curve, Aryl Hydrocarbon Hydroxylases, Breast Neoplasms, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, Estradiol, Estrogens, Estrogens, Catechol, Female, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged, Models, Theoretical, Phenotype, Risk Factors
Added March 20, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.
Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2010) Chem Res Toxicol 23: 1921-35
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Binding Sites, Computer Simulation, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Flavonoids, Humans, Kinetics, Structure-Activity Relationship
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Surfing a genetic association interaction network to identify modulators of antibody response to smallpox vaccine.
Davis NA, Crowe JE, Pajewski NM, McKinney BA
(2010) Genes Immun 11: 630-6
MeSH Terms: Algorithms, Antibody Formation, Cytochrome P-450 CYP1A1, Gene Regulatory Networks, Genes, Genome-Wide Association Study, Humans, Markov Chains, NADPH Oxidases, Phenotype, Polymorphism, Single Nucleotide, Retinoid X Receptor alpha, Smallpox Vaccine
Added August 6, 2012
0 Communities
1 Members
0 Resources
13 MeSH Terms
Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells.
Wang Z, Yang H, Ramesh A, Roberts LJ, Zhou L, Lin X, Zhao Y, Guo Z
(2009) Free Radic Biol Med 47: 1221-9
MeSH Terms: Animals, Aorta, Aryl Hydrocarbon Hydroxylases, Benzo(a)pyrene, Blotting, Western, Catalase, Cells, Cultured, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, Endothelium, Vascular, F2-Isoprostanes, Furans, Glutathione Transferase, Inactivation, Metabolic, Mice, RNA, Messenger, RNA, Small Interfering, Receptors, Aryl Hydrocarbon, Reverse Transcriptase Polymerase Chain Reaction, Superoxide Dismutase, Up-Regulation
Added February 22, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms