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Results: 1 to 10 of 11

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Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Reddish MJ, Guengerich FP
(2019) J Biol Chem 294: 12975-12991
MeSH Terms: 18-Hydroxycorticosterone, Aldosterone, Biocatalysis, Cytochrome P-450 CYP11B2, Humans, Kinetics, Models, Molecular, Molecular Conformation
Added March 3, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis.
Brown NJ
(2013) Nat Rev Nephrol 9: 459-69
MeSH Terms: Aldosterone, Animals, Aromatase Inhibitors, Cardiovascular System, Cytochrome P-450 CYP11B2, Endothelial Cells, Fadrozole, Fibrosis, Humans, Imidazoles, Inflammation, Kidney, Macrophages, Mineralocorticoid Receptor Antagonists, Myocardium, Myocytes, Cardiac, Pyridines, Reactive Oxygen Species, Receptors, Mineralocorticoid, Sodium, Dietary
Added December 10, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms
Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.
Luther JM, Luo P, Wang Z, Cohen SE, Kim HS, Fogo AB, Brown NJ
(2012) Kidney Int 82: 643-51
MeSH Terms: Aldosterone, Angiotensin II, Animals, Aorta, Biomarkers, Blood Pressure, Cytochrome P-450 CYP11B2, Disease Models, Animal, Fibrosis, Gene Expression Regulation, Heart Diseases, Inflammation, Kidney Diseases, Kidney Glomerulus, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mineralocorticoid Receptor Antagonists, Myocardium, Receptors, Mineralocorticoid, Renin-Angiotensin System, Sodium Chloride, Dietary, Spironolactone, Time Factors, Vascular Diseases
Added December 10, 2013
2 Communities
2 Members
0 Resources
25 MeSH Terms
Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.
Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH, Powers AC, Brown NJ
(2011) Diabetologia 54: 2152-63
MeSH Terms: Aldosterone, Animals, Blood Glucose, Cell Line, Cytochrome P-450 CYP11B2, Glucose, In Vitro Techniques, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL
Added December 10, 2013
4 Communities
3 Members
0 Resources
14 MeSH Terms
Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.
Martinerie L, Viengchareun S, Meduri G, Kim HS, Luther JM, Lombès M
(2011) Endocrinology 152: 2483-91
MeSH Terms: Absorption, Aldosterone, Animals, Cytochrome P-450 CYP11B2, Female, Gene Expression, Growth and Development, Humans, Kidney, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Mineralocorticoid, Sodium
Added December 5, 2013
1 Communities
1 Members
0 Resources
15 MeSH Terms
Aldosterone and inflammation.
Gilbert KC, Brown NJ
(2010) Curr Opin Endocrinol Diabetes Obes 17: 199-204
MeSH Terms: Aldosterone, Animals, Cytochrome P-450 CYP11B2, Disease Models, Animal, Humans, Inflammation, Mineralocorticoid Receptor Antagonists, Reactive Oxygen Species, Receptor, Angiotensin, Type 1, Receptors, Mineralocorticoid
Added December 10, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms
Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt.
Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, Brown NJ
(2009) Kidney Int 75: 936-44
MeSH Terms: Angiotensin II, Animals, Cytochrome P-450 CYP11B2, Enzyme Inhibitors, Fibrosis, Heart Diseases, Kidney Diseases, Mineralocorticoid Receptor Antagonists, Rats, Sodium Chloride, Dietary, Spironolactone
Added December 10, 2013
1 Communities
3 Members
0 Resources
11 MeSH Terms
Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta.
Luther JM, Wang Z, Ma J, Makhanova N, Kim HS, Brown NJ
(2009) Endocrinology 150: 2229-36
MeSH Terms: Aldosterone, Angiotensin II, Animals, Aorta, Blood Pressure, Cytochrome P-450 CYP11B2, Drug Interactions, Endothelin-1, Heart, Mice, Mice, Inbred C57BL, Mice, Knockout, Myocardium, Plasminogen Activator Inhibitor 1, Receptor, Angiotensin, Type 1, Time Factors, Up-Regulation
Added December 10, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli.
Zöllner A, Kagawa N, Waterman MR, Nonaka Y, Takio K, Shiro Y, Hannemann F, Bernhardt R
(2008) FEBS J 275: 799-810
MeSH Terms: Chromatography, High Pressure Liquid, Circular Dichroism, Cytochrome P-450 CYP11B2, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Ferredoxins, Flavin-Adenine Dinucleotide, Humans, Kinetics, Mass Spectrometry, NADP, Oxidation-Reduction, Recombinant Proteins, Steroid 11-beta-Hydroxylase, Substrate Specificity
Added February 12, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Structure/function relationship of CYP11B1 associated with Dahl's salt-resistant rats--expression of rat CYP11B1 and CYP11B2 in Escherichia coli.
Nonaka Y, Fujii T, Kagawa N, Waterman MR, Takemori H, Okamoto M
(1998) Eur J Biochem 258: 869-78
MeSH Terms: Amino Acid Sequence, Animals, Base Sequence, Cytochrome P-450 CYP11B2, DNA Primers, Desoxycorticosterone, Immunoblotting, Molecular Sequence Data, Molecular Structure, Mutation, Polymerase Chain Reaction, Rats, Rats, Inbred Dahl, Recombinant Proteins, Steroid 11-beta-Hydroxylase, Steroid Hydroxylases, Steroids, Structure-Activity Relationship, Substrate Specificity
Added February 12, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms