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Genomic Variants of Cytarabine Sensitivity Associated with Treatment-Related Mortality in Pediatric AML: A Report from the Children's Oncology Group.
Phillips CL, Lane A, Gerbing RB, Alonzo TA, Wilkey A, Radloff G, Lange B, Gamazon ER, Dolan ME, Davies SM
(2020) Clin Cancer Res 26: 2891-2897
MeSH Terms: Antimetabolites, Antineoplastic, Biomarkers, Tumor, Child, Cytarabine, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Leukemia, Myeloid, Acute, Polymorphism, Single Nucleotide, Prognosis, Prospective Studies, Survival Rate
Added March 10, 2020
0 Communities
1 Members
0 Resources
12 MeSH Terms
Comparison of 60 and 80 mg/m of daunorubicin in induction therapy of acute myeloid leukaemia.
Vaezi M, Bahar B, Mousavi A, Yaghmai M, Kasaeian A, Souri M, Jahani M, Alimoghaddam K, Ghavamzadeh A
(2017) Hematol Oncol 35: 101-105
MeSH Terms: Adolescent, Adult, Antibiotics, Antineoplastic, Chromosome Aberrations, Cytarabine, Daunorubicin, Disease-Free Survival, Dose-Response Relationship, Drug, Drug Administration Schedule, Febrile Neutropenia, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Leukemia, Myeloid, Acute, Male, Middle Aged, Mycoses, Neutropenia, Prevalence, Prospective Studies, Remission Induction, Treatment Outcome, Young Adult
Added September 28, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients.
Gamazon ER, Lamba JK, Pounds S, Stark AL, Wheeler HE, Cao X, Im HK, Mitra AK, Rubnitz JE, Ribeiro RC, Raimondi S, Campana D, Crews KR, Wong SS, Welsh M, Hulur I, Gorsic L, Hartford CM, Zhang W, Cox NJ, Dolan ME
(2013) Blood 121: 4366-76
MeSH Terms: Antimetabolites, Antineoplastic, Apoptosis, Cytarabine, Drug Resistance, Neoplasm, Gene Expression Regulation, Leukemic, Genome-Wide Association Study, Genotype, Humans, Leukemia, Myeloid, Acute, Phenotype, Polymorphism, Single Nucleotide, Treatment Outcome
Added February 22, 2016
0 Communities
2 Members
0 Resources
12 MeSH Terms
Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer.
Nifoussi SK, Vrana JA, Domina AM, De Biasio A, Gui J, Gregory MA, Hann SR, Craig RW
(2012) PLoS One 7: e47060
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Blotting, Western, CHO Cells, Cell Line, Tumor, Cisplatin, Cricetinae, Cytarabine, Drug Resistance, Neoplasm, Etoposide, Flow Cytometry, Glycogen Synthase Kinase 3, Humans, Myeloid Cell Leukemia Sequence 1 Protein, Phosphorylation, Protein Stability, Proto-Oncogene Proteins c-bcl-2, Threonine, Vinblastine
Added March 20, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.
Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, Kriegstein AR, Alvarez-Buylla A
(2011) Neuron 71: 250-62
MeSH Terms: Age Factors, Animals, Calbindins, Cell Movement, Cerebral Ventricles, Choline O-Acetyltransferase, Cytarabine, Estrogen Antagonists, Gene Expression Regulation, Hedgehog Proteins, Immunosuppressive Agents, Kruppel-Like Transcription Factors, Luminescent Proteins, Mice, Mice, Transgenic, Neural Stem Cells, Neurons, Olfactory Bulb, RNA, Messenger, Receptors, G-Protein-Coupled, S100 Calcium Binding Protein G, Signal Transduction, Smoothened Receptor, Stilbamidines, Tamoxifen, Time Factors, Tyrosine 3-Monooxygenase, Zinc Finger Protein GLI1
Added August 21, 2012
1 Communities
1 Members
0 Resources
28 MeSH Terms
Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses.
Robinson KE, Livesay KL, Campbell LK, Scaduto M, Cannistraci CJ, Anderson AW, Whitlock JA, Compas BE
(2010) Pediatr Blood Cancer 54: 585-90
MeSH Terms: Adolescent, Age of Onset, Antineoplastic Agents, Brain, Brain Mapping, Child, Child, Preschool, Cytarabine, Female, Humans, Intelligence Tests, Magnetic Resonance Imaging, Male, Memory Disorders, Memory, Short-Term, Methotrexate, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Survivors
Added March 7, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.
Ge Y, Jensen TL, Stout ML, Flatley RM, Grohar PJ, Ravindranath Y, Matherly LH, Taub JW
(2004) Cancer Res 64: 728-35
MeSH Terms: Base Sequence, Cell Death, Cell Line, Tumor, Cells, Cultured, Cytarabine, Cytosine Deaminase, DNA Primers, DNA-Binding Proteins, Down Syndrome, Erythroid-Specific DNA-Binding Factors, Exons, GATA1 Transcription Factor, Humans, Introns, Leukemia, Molecular Sequence Data, Reverse Transcriptase Polymerase Chain Reaction, Transcription Factors, Transcription, Genetic
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Age and cytogenetics as predictors of event free survival in patients with acute non-lymphocytic leukemia receiving high dose cytosine arabinoside and daunorubicin as consolidation chemotherapy.
Stein RS, Wolff SN, Greer JP, Flexner JM, Goodman S, Jagasia M, Brandt SJ, Morgan DS, Arrowsmith E, McCurley TL
(2001) Leuk Lymphoma 42: 913-22
MeSH Terms: Actuarial Analysis, Adult, Age Factors, Antineoplastic Combined Chemotherapy Protocols, Cytarabine, Cytogenetic Analysis, Daunorubicin, Disease-Free Survival, Female, Humans, Leukemia, Myeloid, Acute, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors
Added March 5, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Cytosine arabinoside lesions are position-specific topoisomerase II poisons and stimulate DNA cleavage mediated by the human type II enzymes.
Cline SD, Osheroff N
(1999) J Biol Chem 274: 29740-3
MeSH Terms: Base Sequence, Cytarabine, DNA, DNA Primers, Humans, Hydrolysis, Topoisomerase II Inhibitors
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Feasibility of five courses of pre-operative chemotherapy in patients with resectable adenocarcinoma of the oesophagus or gastrooesophageal junction.
Ajani JA, Roth JA, Putnam JB, Walsh G, Lynch PM, Roubein LD, Ryan MB, Natrajan G, Gould P
(1995) Eur J Cancer 31A: 665-70
MeSH Terms: Adenocarcinoma, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Cisplatin, Combined Modality Therapy, Cytarabine, Drug Administration Schedule, Esophageal Neoplasms, Female, Fluorouracil, Humans, Male, Middle Aged, Premedication, Stomach Neoplasms, Survival Rate, Ultrasonography
Added March 27, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms