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Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP
(2020) Science 368: 85-89
MeSH Terms: Animals, Carcinoma, Pancreatic Ductal, Cationic Amino Acid Transporter 1, Cell Line, Tumor, Cystathionine gamma-Lyase, Cysteine, Cystine, Ferroptosis, Gene Deletion, Humans, Mice, Mice, Mutant Strains, Pancreatic Neoplasms
Added March 13, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.
Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP
(2018) Oncogene 37: 5007-5019
MeSH Terms: 3T3 Cells, A549 Cells, Amino Acid Transport System y+, Animals, Carcinoma, Non-Small-Cell Lung, Cell Line, Cell Line, Tumor, Cell Proliferation, Cell Survival, Cystine, Cytoplasm, Disease Progression, Female, Glutamine, Humans, Lung Neoplasms, Male, Mice, Middle Aged
Added March 28, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Clinical Outcomes for Cystinuria Patients with Unilateral Versus Bilateral Cystine Stone Disease.
Usawachintachit M, Sherer B, Hudnall M, Tzou DT, Taguchi K, Hsi RS, Stoller M, Chi T
(2018) J Endourol 32: 148-153
MeSH Terms: Adult, Aged, Case-Control Studies, Cystine, Cystinuria, Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Calculi, Male, Middle Aged, Retrospective Studies, San Francisco
Added January 16, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.
Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC
(2016) J Immunol Methods 438: 51-58
MeSH Terms: Amino Acid Transport System y+, B-Lymphocytes, Cell Line, Tumor, Cellular Reprogramming, Cystine, Flow Cytometry, Fluorescein-5-isothiocyanate, Fluorescence, Fluorescent Dyes, Glutathione, Humans, Lymphocyte Activation, Microscopy, Fluorescence, Reactive Oxygen Species, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Up-Regulation
Added January 29, 2018
0 Communities
1 Members
0 Resources
18 MeSH Terms
The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: a pilot investigation.
Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P
(2012) Am J Ophthalmol 153: 1104-9.e2
MeSH Terms: Aged, Antioxidants, Ascorbic Acid, Biomarkers, Copper, Cysteine, Cystine, Dietary Supplements, Female, Furans, Glutathione, Humans, Isoprostanes, Macular Degeneration, Male, Oxidative Stress, Pilot Projects, Prospective Studies, Vitamin E, Zinc Oxide, beta Carotene
Added December 10, 2013
1 Communities
2 Members
0 Resources
21 MeSH Terms
Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration.
Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P
(2012) Am J Ophthalmol 153: 460-467.e1
MeSH Terms: Aged, Biomarkers, Case-Control Studies, Chromatography, High Pressure Liquid, Complement Factor H, Cysteine, Cystine, Female, Furans, Genetic Predisposition to Disease, Genetic Variation, Genotype, Glutathione, Humans, Isoprostanes, Lipid Peroxidation, Macular Degeneration, Male, Oxidative Stress, Polymorphism, Single Nucleotide, Prospective Studies, Proteins
Added December 10, 2013
1 Communities
2 Members
0 Resources
22 MeSH Terms
Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase.
May JM, Cobb CE, Mendiratta S, Hill KE, Burk RF
(1998) J Biol Chem 273: 23039-45
MeSH Terms: Animals, Aurothioglucose, Cystine, Cytosol, Dehydroascorbic Acid, Electron Spin Resonance Spectroscopy, Free Radicals, Liver, Metalloproteins, Microsomes, Liver, NADP, Organoselenium Compounds, Oxidation-Reduction, Rats, Selenium, Thioredoxin-Disulfide Reductase
Added December 10, 2013
0 Communities
3 Members
0 Resources
16 MeSH Terms
Failure of chronic glutathione elevation to reduce cytotoxicity produced by exposure to cis-diamminedichloroplatinum(II), ionizing radiation, or hyperthermia.
Freeman ML, Meredith MJ, Eisert DR
(1990) Cancer Res 50: 5296-300
MeSH Terms: Animals, Biological Transport, Cell Cycle, Cell Line, Cell Survival, Cisplatin, Cricetinae, Cricetulus, Cystine, Feedback, Female, Gamma Rays, Glutamate-Cysteine Ligase, Glutathione, Glutathione Transferase, Hot Temperature, Kinetics, Maleates, Ovary, Protein Biosynthesis, Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
An AB initio investigation of molecules with a disulfide bond: (HS)2, (CH3S)2 and cystine.
Eslava LA, Putnam JB, Pedersen L
(1978) Int J Pept Protein Res 11: 149-53
MeSH Terms: Chemical Phenomena, Chemistry, Cystine, Disulfides, Hydrogen Bonding, Molecular Conformation
Added March 27, 2014
0 Communities
1 Members
0 Resources
6 MeSH Terms