Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors.
Beeghly-Fadiel A, Wilson AJ, Keene S, El Ramahi M, Xu S, Marnett LJ, Fadare O, Crispens MA, Khabele D
(2018) J Ovarian Res 11
: 17MeSH Terms: Aged, Biomarkers, Tumor, Cyclooxygenase 1, Cyclooxygenase 2, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Middle Aged, Neoplasm Grading, Neoplasm Staging, Ovarian Neoplasms, Prognosis, Proportional Hazards Models, Prostaglandin-Endoperoxide SynthasesAdded March 21, 2018
16 MeSH Terms
Prostaglandin-Endoperoxide Synthase 1 Mediates the Timing of Parturition in Mice Despite Unhindered Uterine Contractility.
Herington JL, O'Brien C, Robuck MF, Lei W, Brown N, Slaughter JC, Paria BC, Mahadevan-Jansen A, Reese J
(2018) Endocrinology 159
: 490-505MeSH Terms: Abortifacient Agents, Steroidal, Animals, Cells, Cultured, Cervical Ripening, Cervix Uteri, Cyclooxygenase 1, Female, In Vitro Techniques, Luteolysis, Membrane Proteins, Mice, Inbred Strains, Mice, Knockout, Mifepristone, Myometrium, Ovariectomy, Oxytocics, Oxytocin, Pregnancy, Pregnancy, Prolonged, Progesterone, Uterine ContractionAdded March 31, 2018
In vivo Raman spectral analysis of impaired cervical remodeling in a mouse model of delayed parturition.
O'Brien CM, Herington JL, Brown N, Pence IJ, Paria BC, Slaughter JC, Reese J, Mahadevan-Jansen A
(2017) Sci Rep 7
: 6835MeSH Terms: Animals, Cervix Uteri, Cyclooxygenase 1, Extracellular Matrix Proteins, Female, Lipid Metabolism, Membrane Proteins, Mice, Nucleic Acids, Spectrum Analysis, Raman, Term Birth, Uterine ContractionAdded October 11, 2017
12 MeSH Terms
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.
Dolan JM, Weinberg JB, O'Brien E, Abashian A, Procario MC, Aronoff DM, Crofford LJ, Peters-Golden M, Ward L, Mancuso P
(2016) Am J Physiol Lung Cell Mol Physiol 310
: L1111-20MeSH Terms: Animals, Cyclooxygenase 1, Cytokines, Dinoprostone, Female, Immunity, Innate, Lung, Macrophages, Alveolar, Membrane Proteins, Mice, Inbred C57BL, Mice, Knockout, Microsomes, Nitric Oxide, Pneumonia, Pneumococcal, Streptococcus pneumoniaeAdded June 2, 2017
15 MeSH Terms
Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer.
Wilson AJ, Fadare O, Beeghly-Fadiel A, Son DS, Liu Q, Zhao S, Saskowski J, Uddin MJ, Daniel C, Crews B, Lehmann BD, Pietenpol JA, Crispens MA, Marnett LJ, Khabele D
(2015) Oncotarget 6
: 21353-68MeSH Terms: Carcinoma, Ovarian Epithelial, Cell Line, Tumor, Cell Movement, Cell Proliferation, Computational Biology, Cyclooxygenase 1, Female, Gene Expression Profiling, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Genome, Human, Humans, Immunohistochemistry, Neoplasm Invasiveness, Neoplasms, Glandular and Epithelial, Neovascularization, Pathologic, Oligonucleotide Array Sequence Analysis, Ovarian Neoplasms, Signal TransductionAdded July 28, 2015
19 MeSH Terms
Conjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance.
Neumann W, Crews BC, Sárosi MB, Daniel CM, Ghebreselasie K, Scholz MS, Marnett LJ, Hey-Hawkins E
(2015) ChemMedChem 10
: 183-92MeSH Terms: Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Cisplatin, Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase Inhibitors, Drug Resistance, Neoplasm, HCT116 Cells, HumansAdded February 22, 2016
10 MeSH Terms
ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations.
Beavers WN, Serwa R, Shimozu Y, Tallman KA, Vaught M, Dalvie ED, Marnett LJ, Porter NA
(2014) J Am Chem Soc 136
: 11529-39MeSH Terms: Animals, Arachidonate 15-Lipoxygenase, Arachidonic Acid, Carbon, Cell Line, Chromatography, High Pressure Liquid, Cyclooxygenase 1, Cyclooxygenase 2, Fatty Acids, Fatty Acids, Unsaturated, Free Radicals, Hydroxyeicosatetraenoic Acids, Linoleic Acid, Lipids, Lipoxygenases, Macromolecular Substances, Macrophages, Mice, Oxygen, Soybeans, Spectrophotometry, Ultraviolet, Tandem Mass SpectrometryAdded February 22, 2016
22 MeSH Terms
PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.
Perrone MG, Malerba P, Uddin J, Vitale P, Panella A, Crews BC, Daniel CK, Ghebreselasie K, Nickels M, Tantawy MN, Manning HC, Marnett LJ, Scilimati A
(2014) Eur J Med Chem 80
: 562-568MeSH Terms: Animals, Biomarkers, Tumor, Cell Line, Tumor, Cell Transformation, Neoplastic, Cyclooxygenase 1, Cyclooxygenase Inhibitors, Female, Fluorine Radioisotopes, Furans, Humans, Isoxazoles, Mice, Ovarian Neoplasms, Positron-Emission Tomography, Radioactive Tracers, Radiochemistry, Tomography, X-Ray ComputedAdded May 20, 2014
17 MeSH Terms
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.
Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ
(2014) J Biol Chem 289
: 6799-6808MeSH Terms: Amino Acid Substitution, Animals, Anti-Inflammatory Agents, Non-Steroidal, Arginine, Binding Sites, Catalytic Domain, Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase Inhibitors, Hydrogen Bonding, Leucine, Meloxicam, Mice, Mutation, Piroxicam, Protein Structure, Secondary, Serine, Thiazines, Thiazoles, Tyrosine, WaterAdded March 27, 2014
21 MeSH Terms
Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome.
Kawai VK, Avalos I, Oeser A, Oates JA, Milne GL, Solus JF, Chung CP, Stein CM
(2014) Arthritis Care Res (Hoboken) 66
: 285-92MeSH Terms: Adult, Aspirin, Biomarkers, Blood Platelets, C-Reactive Protein, Chi-Square Distribution, Cyclooxygenase 1, Cyclooxygenase Inhibitors, Female, Humans, Lupus Erythematosus, Systemic, Male, Metabolic Syndrome, Middle Aged, Obesity, Prospective Studies, Thromboxane B2, Time Factors, Treatment OutcomeAdded March 7, 2014
19 MeSH Terms