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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 59

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MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
Vilgelm AE, Saleh N, Shattuck-Brandt R, Riemenschneider K, Slesur L, Chen SC, Johnson CA, Yang J, Blevins A, Yan C, Johnson DB, Al-Rohil RN, Halilovic E, Kauffmann RM, Kelley M, Ayers GD, Richmond A
(2019) Sci Transl Med 11:
MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Cell Cycle, Cell Survival, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase Inhibitor p21, DNA Replication, Dimethyl Sulfoxide, Humans, Immunoprecipitation, MCF-7 Cells, Melanoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Proteomics, Proto-Oncogene Proteins c-mdm2, Radioimmunoprecipitation Assay
Added September 27, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
MDM2 Antagonists Counteract Drug-Induced DNA Damage.
Vilgelm AE, Cobb P, Malikayil K, Flaherty D, Andrew Johnson C, Raman D, Saleh N, Higgins B, Vara BA, Johnston JN, Johnson DB, Kelley MC, Chen SC, Ayers GD, Richmond A
(2017) EBioMedicine 24: 43-55
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Azepines, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, DNA Damage, DNA Replication, HCT116 Cells, Humans, Imidazoles, Melanoma, Mice, Piperazines, Protein Binding, Proto-Oncogene Proteins c-mdm2, Pyrimidines, Pyrrolidines, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays, para-Aminobenzoates
Added June 20, 2018
1 Communities
2 Members
0 Resources
MeSH Terms
Phosphatidylinositol 3-kinase signaling determines kidney size.
Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, Sha F, Ikizler TA, Quarles CC, Threadgill DW, Neilson EG, Harris RC
(2015) J Clin Invest 125: 2429-44
MeSH Terms: Animals, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Immunosuppressive Agents, Kidney, Kidney Diseases, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Inbred DBA, Mice, Knockout, Multiprotein Complexes, Organ Size, Phosphatidylinositol 3-Kinases, Phosphorylation, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases
Added August 5, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium.
Chaum E, Winborn CS, Bhattacharya S
(2015) Mamm Genome 26: 210-21
MeSH Terms: Adult, Aged, 80 and over, Aging, Animals, Apoptosis, Caspases, Caspases, Initiator, Cell Line, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p21, Gene Expression Regulation, Humans, Immunity, Innate, Interferon-alpha, Interferon-gamma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Primary Cell Culture, Quantitative Trait Loci, Retinal Pigment Epithelium, Signal Transduction, Toll-Like Receptor 4, Tumor Suppressor Protein p53
Added June 11, 2018
0 Communities
1 Members
0 Resources
25 MeSH Terms
Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells.
Diekman BO, Thakore PI, O'Connor SK, Willard VP, Brunger JM, Christoforou N, Leong KW, Gersbach CA, Guilak F
(2015) Tissue Eng Part A 21: 1261-74
MeSH Terms: Animals, Bromodeoxyuridine, Cartilage, Cell Differentiation, Cell Proliferation, Cells, Cultured, Chondrogenesis, Collagen, Collagen Type I, Collagen Type X, Cyclin-Dependent Kinase Inhibitor p21, DNA, Gene Expression Regulation, Gene Knockdown Techniques, Glycosaminoglycans, Immunohistochemistry, Induced Pluripotent Stem Cells, Mice
Added March 16, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.
Koh DI, Han D, Ryu H, Choi WI, Jeon BN, Kim MK, Kim Y, Kim JY, Parry L, Clarke AR, Reynolds AB, Hur MW
(2014) Proc Natl Acad Sci U S A 111: 15078-83
MeSH Terms: Acetylation, Animals, Apoptosis, Cell Cycle, Cell Line, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p21, DNA, DNA Damage, DNA Methylation, E1A-Associated p300 Protein, Female, Fibroblasts, HCT116 Cells, HEK293 Cells, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Promoter Regions, Genetic, Protein Binding, Response Elements, Transcription Factors, Tumor Suppressor Protein p53
Added May 2, 2016
1 Communities
1 Members
0 Resources
24 MeSH Terms
Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction.
Spurlock CF, Tossberg JT, Matlock BK, Olsen NJ, Aune TM
(2014) Arthritis Rheumatol 66: 2947-57
MeSH Terms: Adult, Antirheumatic Agents, Arthritis, Rheumatoid, Cell Line, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p21, DNA-Activated Protein Kinase, Dose-Response Relationship, Drug, Female, Humans, Male, Methotrexate, Middle Aged, Monocytes, NF-kappa B, Nuclear Proteins, RNA, Long Noncoding, T-Lymphocytes, Tumor Suppressor Protein p53, eIF-2 Kinase
Added January 21, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice.
Zeng F, Miyazawa T, Kloepfer LA, Harris RC
(2014) Kidney Int 86: 538-47
MeSH Terms: Animals, Apoptosis, Blood Urea Nitrogen, Caspase 3, Cell Proliferation, Cyclin D, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Disease Models, Animal, Disease Progression, Epithelial Cells, Fibrosis, Gene Deletion, Kidney Cortex, Kidney Medulla, Mice, Organ Size, Polycystic Kidney Diseases, Receptor, ErbB-4
Added October 27, 2014
1 Communities
1 Members
0 Resources
19 MeSH Terms
Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis.
Jiang L, Yang S, Yin H, Fan X, Wang S, Yao B, Pozzi A, Chen X, Harris RC, Zhang MZ
(2013) Mol Cancer Res 11: 1040-50
MeSH Terms: 11-beta-Hydroxysteroid Dehydrogenase Type 2, Adenoma, Animals, Carcinogenesis, Cell Cycle, Cell Line, Tumor, Colonic Neoplasms, Corticosterone, Cyclin-Dependent Kinase Inhibitor p21, Cyclooxygenase 2, Disease Models, Animal, Gene Expression Regulation, Neoplastic, Genes, APC, Humans, Intestinal Mucosa, Mice, Mice, Inbred C57BL, Sequence Deletion, TOR Serine-Threonine Kinases, Transcription Factors, Tumor Suppressor Protein p53
Added February 26, 2014
1 Communities
3 Members
0 Resources
21 MeSH Terms
Differential regulation of cyclin-dependent kinase inhibitors in neuroblastoma cells.
Qiao L, Paul P, Lee S, Qiao J, Wang Y, Chung DH
(2013) Biochem Biophys Res Commun 435: 295-9
MeSH Terms: Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Gastrin-Releasing Peptide, Gene Expression Regulation, Neoplastic, Humans, Neuroblastoma, PTEN Phosphohydrolase, Receptors, Bombesin
Added March 7, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms