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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 25

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MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
Vilgelm AE, Saleh N, Shattuck-Brandt R, Riemenschneider K, Slesur L, Chen SC, Johnson CA, Yang J, Blevins A, Yan C, Johnson DB, Al-Rohil RN, Halilovic E, Kauffmann RM, Kelley M, Ayers GD, Richmond A
(2019) Sci Transl Med 11:
MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Cell Cycle, Cell Survival, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase Inhibitor p21, DNA Replication, Dimethyl Sulfoxide, Humans, Immunoprecipitation, MCF-7 Cells, Melanoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Proteomics, Proto-Oncogene Proteins c-mdm2, Radioimmunoprecipitation Assay
Added September 27, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer.
Formisano L, Lu Y, Servetto A, Hanker AB, Jansen VM, Bauer JA, Sudhan DR, Guerrero-Zotano AL, Croessmann S, Guo Y, Ericsson PG, Lee KM, Nixon MJ, Schwarz LJ, Sanders ME, Dugger TC, Cruz MR, Behdad A, Cristofanilli M, Bardia A, O'Shaughnessy J, Nagy RJ, Lanman RB, Solovieff N, He W, Miller M, Su F, Shyr Y, Mayer IA, Balko JM, Arteaga CL
(2019) Nat Commun 10: 1373
MeSH Terms: Aminopyridines, Animals, Antineoplastic Agents, Hormonal, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Circulating Tumor DNA, Cyclin D1, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Drug Resistance, Neoplasm, Female, Fulvestrant, High-Throughput Nucleotide Sequencing, Humans, MCF-7 Cells, Mice, Mutation, Naphthalenes, Piperazines, Progression-Free Survival, Proportional Hazards Models, Protein Kinase Inhibitors, Purines, Pyrazoles, Pyridines, Quinolines, Quinoxalines, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Receptors, Estrogen, Signal Transduction, Xenograft Model Antitumor Assays
Added April 2, 2019
0 Communities
1 Members
0 Resources
32 MeSH Terms
Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.
Bhuripanyo K, Wang Y, Liu X, Zhou L, Liu R, Duong D, Zhao B, Bi Y, Zhou H, Chen G, Seyfried NT, Chazin WJ, Kiyokawa H, Yin J
(2018) Sci Adv 4: e1701393
MeSH Terms: Amino Acid Sequence, Bacteriophages, Biocatalysis, Cyclin-Dependent Kinase 4, Endoplasmic Reticulum Stress, HEK293 Cells, Humans, Mutant Proteins, Mutation, Peptides, Proteolysis, Reproducibility of Results, Signal Transduction, Substrate Specificity, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Ubiquitin, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, Ubiquitination
Added March 24, 2018
0 Communities
1 Members
0 Resources
20 MeSH Terms
Genomic profiling of ER breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.
Giltnane JM, Hutchinson KE, Stricker TP, Formisano L, Young CD, Estrada MV, Nixon MJ, Du L, Sanchez V, Ericsson PG, Kuba MG, Sanders ME, Mu XJ, Van Allen EM, Wagle N, Mayer IA, Abramson V, Gόmez H, Rizzo M, Toy W, Chandarlapaty S, Mayer EL, Christiansen J, Murphy D, Fitzgerald K, Wang K, Ross JS, Miller VA, Stephens PJ, Yelensky R, Garraway L, Shyr Y, Meszoely I, Balko JM, Arteaga CL
(2017) Sci Transl Med 9:
MeSH Terms: Breast Neoplasms, Cell Line, Tumor, Cyclin D1, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Female, Humans, In Vitro Techniques, Receptor, ErbB-2, Receptor, Fibroblast Growth Factor, Type 1, Receptors, Estrogen
Added March 14, 2018
0 Communities
2 Members
0 Resources
11 MeSH Terms
Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment.
Vilgelm AE, Johnson CA, Prasad N, Yang J, Chen SC, Ayers GD, Pawlikowski JS, Raman D, Sosman JA, Kelley M, Ecsedy JA, Shyr Y, Levy SE, Richmond A
(2016) J Natl Cancer Inst 108: djv406
MeSH Terms: Animals, Aurora Kinase A, Cell Line, Tumor, Cellular Senescence, Chemokine CCL5, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Gene Expression Regulation, Neoplastic, Heterografts, Humans, Immunocompetence, Immunocompromised Host, Immunotherapy, Lymphocyte Activation, Lymphocytes, Tumor-Infiltrating, Melanoma, Mice, Real-Time Polymerase Chain Reaction, Skin Neoplasms, Transcriptome, Tumor Microenvironment, Tumor Necrosis Factor Receptor Superfamily, Member 9
Added January 18, 2016
2 Communities
3 Members
0 Resources
25 MeSH Terms
Liposarcomatous differentiation in malignant phyllodes tumours is unassociated with MDM2 or CDK4 amplification.
Lyle PL, Bridge JA, Simpson JF, Cates JM, Sanders ME
(2016) Histopathology 68: 1040-5
MeSH Terms: Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Breast Neoplasms, Cell Differentiation, Cyclin-Dependent Kinase 4, Female, Gene Amplification, Humans, In Situ Hybridization, Fluorescence, Liposarcoma, Middle Aged, Nerve Sheath Neoplasms, Phenotype, Phyllodes Tumor, Proto-Oncogene Proteins c-mdm2
Added February 15, 2016
0 Communities
1 Members
0 Resources
17 MeSH Terms
Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish.
Li M, Maddison LA, Crees Z, Chen W
(2013) Zebrafish 10: 170-6
MeSH Terms: Animals, Animals, Genetically Modified, Cell Count, Cell Division, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase Inhibitor Proteins, Fluorescent Antibody Technique, Insulin, Insulin-Secreting Cells, Larva, Zebrafish, Zebrafish Proteins
Added April 24, 2014
1 Communities
1 Members
0 Resources
12 MeSH Terms
ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer.
Miller TW, Balko JM, Fox EM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, Jiang A, Smith RA, Maira SM, Manning HC, González-Angulo AM, Mills GB, Higham C, Chanthaphaychith S, Kuba MG, Miller WR, Shyr Y, Arteaga CL
(2011) Cancer Discov 1: 338-51
MeSH Terms: Animals, Breast Neoplasms, Cell Line, Tumor, Cyclin-Dependent Kinase 4, Down-Regulation, Drug Resistance, Neoplasm, E2F Transcription Factors, Estrogen Receptor Modulators, Estrogen Receptor alpha, Estrogens, Female, Gene Expression, Humans, Mice, Mice, Nude, Phosphatidylinositol 3-Kinases, Transcription, Genetic
Added March 5, 2014
0 Communities
4 Members
0 Resources
17 MeSH Terms
Conditional ablation of Ikkb inhibits melanoma tumor development in mice.
Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A
(2010) J Clin Invest 120: 2563-74
MeSH Terms: Animals, Apoptosis, Aurora Kinase A, Aurora Kinase B, Aurora Kinases, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 4, Genes, ras, I-kappa B Kinase, Melanocytes, Melanoma, Mice, Mice, Knockout, Mice, Transgenic, NF-kappa B, Neoplasms, Phosphorylation, Protein-Serine-Threonine Kinases, Transcription Factor RelA, Transcription, Genetic, Tumor Suppressor Protein p53
Added June 14, 2013
3 Communities
3 Members
0 Resources
21 MeSH Terms
Down-regulation of p57Kip2 induces prostate cancer in the mouse.
Jin RJ, Lho Y, Wang Y, Ao M, Revelo MP, Hayward SW, Wills ML, Logan SK, Zhang P, Matusik RJ
(2008) Cancer Res 68: 3601-8
MeSH Terms: Animals, Cell Differentiation, Cell Line, Tumor, Cell Transformation, Neoplastic, Cyclin D, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase Inhibitor p57, Cyclins, Down-Regulation, Gene Expression Regulation, Neoplastic, Humans, Male, Mice, Prostatic Neoplasms, Retinoblastoma Protein
Added December 10, 2013
1 Communities
3 Members
0 Resources
16 MeSH Terms