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Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer.
Formisano L, Lu Y, Servetto A, Hanker AB, Jansen VM, Bauer JA, Sudhan DR, Guerrero-Zotano AL, Croessmann S, Guo Y, Ericsson PG, Lee KM, Nixon MJ, Schwarz LJ, Sanders ME, Dugger TC, Cruz MR, Behdad A, Cristofanilli M, Bardia A, O'Shaughnessy J, Nagy RJ, Lanman RB, Solovieff N, He W, Miller M, Su F, Shyr Y, Mayer IA, Balko JM, Arteaga CL
(2019) Nat Commun 10: 1373
MeSH Terms: Aminopyridines, Animals, Antineoplastic Agents, Hormonal, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Circulating Tumor DNA, Cyclin D1, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Drug Resistance, Neoplasm, Female, Fulvestrant, High-Throughput Nucleotide Sequencing, Humans, MCF-7 Cells, Mice, Mutation, Naphthalenes, Piperazines, Progression-Free Survival, Proportional Hazards Models, Protein Kinase Inhibitors, Purines, Pyrazoles, Pyridines, Quinolines, Quinoxalines, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Receptors, Estrogen, Signal Transduction, Xenograft Model Antitumor Assays
Added April 2, 2019
0 Communities
1 Members
0 Resources
32 MeSH Terms
Genomic profiling of ER breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.
Giltnane JM, Hutchinson KE, Stricker TP, Formisano L, Young CD, Estrada MV, Nixon MJ, Du L, Sanchez V, Ericsson PG, Kuba MG, Sanders ME, Mu XJ, Van Allen EM, Wagle N, Mayer IA, Abramson V, Gόmez H, Rizzo M, Toy W, Chandarlapaty S, Mayer EL, Christiansen J, Murphy D, Fitzgerald K, Wang K, Ross JS, Miller VA, Stephens PJ, Yelensky R, Garraway L, Shyr Y, Meszoely I, Balko JM, Arteaga CL
(2017) Sci Transl Med 9:
MeSH Terms: Breast Neoplasms, Cell Line, Tumor, Cyclin D1, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Female, Humans, In Vitro Techniques, Receptor, ErbB-2, Receptor, Fibroblast Growth Factor, Type 1, Receptors, Estrogen
Added March 14, 2018
0 Communities
2 Members
0 Resources
11 MeSH Terms
Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells.
Banerjee RR, Cyphert HA, Walker EM, Chakravarthy H, Peiris H, Gu X, Liu Y, Conrad E, Goodrich L, Stein RW, Kim SK
(2016) Diabetes 65: 2331-41
MeSH Terms: Animals, Cell Proliferation, Cells, Cultured, Cyclin A2, Cyclin B1, Cyclin B2, Cyclin D1, Cyclin D2, Diabetes, Gestational, Female, Forkhead Box Protein M1, Insulin, Insulin-Secreting Cells, MafB Transcription Factor, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Pregnancy, Receptors, Prolactin, Serotonin, Signal Transduction, Tryptophan Hydroxylase
Added September 19, 2016
0 Communities
1 Members
0 Resources
23 MeSH Terms
Comprehensive genomic profiles of small cell lung cancer.
George J, Lim JS, Jang SJ, Cun Y, Ozretić L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK
(2015) Nature 524: 47-53
MeSH Terms: Alleles, Animals, Cell Line, Tumor, Chromosome Breakpoints, Cyclin D1, DNA-Binding Proteins, Disease Models, Animal, Female, Gene Expression Profiling, Genome, Human, Genomics, Humans, Lung Neoplasms, Male, Mice, Mutation, Neurosecretory Systems, Nuclear Proteins, Receptors, Notch, Retinoblastoma Protein, Signal Transduction, Small Cell Lung Carcinoma, Tumor Protein p73, Tumor Suppressor Protein p53, Tumor Suppressor Proteins
Added February 16, 2016
0 Communities
1 Members
0 Resources
25 MeSH Terms
Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice.
Scheving LA, Zhang X, Stevenson MC, Threadgill DW, Russell WE
(2015) Am J Physiol Gastrointest Liver Physiol 308: G364-77
MeSH Terms: Animals, Carbon Tetrachloride, Chemical and Drug Induced Liver Injury, Cyclin A, Cyclin D1, Epidermal Growth Factor, ErbB Receptors, Hepatocytes, Liver Regeneration, Mice, Neuregulin-1, Proto-Oncogene Proteins c-met, Receptor, ErbB-3
Added May 5, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma.
Andl T, Le Bras GF, Richards NF, Allison GL, Loomans HA, Washington MK, Revetta F, Lee RK, Taylor C, Moses HL, Andl CD
(2014) Carcinogenesis 35: 2602-10
MeSH Terms: Animals, Antigens, CD, Cadherins, Carcinogenesis, Carcinoma, Squamous Cell, Cell Proliferation, Cyclin D1, Epithelial Cells, Homeostasis, Humans, Mice, Mouth Neoplasms, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Tamoxifen
Added December 3, 2014
2 Communities
3 Members
0 Resources
17 MeSH Terms
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG, Zhang Q
(2014) Genes Dev 28: 1429-44
MeSH Terms: Animals, Cell Line, Cells, Cultured, Cyclin D1, Forkhead Box Protein O3, Forkhead Transcription Factors, Gene Expression Regulation, Neoplastic, Hydroxylation, Hypoxia-Inducible Factor-Proline Dioxygenases, MCF-7 Cells, Mice, Protein Binding, Protein Stability, Ubiquitin Thiolesterase
Added March 4, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.
Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB
(2014) Cancer Res 74: 2062-72
MeSH Terms: ADAM Proteins, ADAM17 Protein, Amphiregulin, Bile Acids and Salts, Cyclin D1, Deoxycholic Acid, EGF Family of Proteins, ErbB Receptors, Gastrointestinal Neoplasms, Glycoproteins, HCT116 Cells, Humans, Intercellular Signaling Peptides and Proteins, Pancreas, Phosphorylation, Receptors, G-Protein-Coupled, STAT3 Transcription Factor, Transforming Growth Factor alpha, src-Family Kinases
Added February 14, 2014
0 Communities
3 Members
0 Resources
19 MeSH Terms
Mapping C-terminal transactivation domains of the nuclear HER family receptor tyrosine kinase HER3.
Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL
(2013) PLoS One 8: e71518
MeSH Terms: Cell Line, Cell Nucleus, Cyclin D1, Humans, Mutation, Promoter Regions, Genetic, Protein Structure, Tertiary, Receptor, ErbB-3, Transcriptional Activation
Added June 22, 2015
0 Communities
1 Members
0 Resources
9 MeSH Terms
PIK3CA and APC mutations are synergistic in the development of intestinal cancers.
Deming DA, Leystra AA, Nettekoven L, Sievers C, Miller D, Middlebrooks M, Clipson L, Albrecht D, Bacher J, Washington MK, Weichert J, Halberg RB
(2014) Oncogene 33: 2245-54
MeSH Terms: Adenocarcinoma, Adenomatous Polyposis Coli Protein, Animals, Cell Nucleus, Class I Phosphatidylinositol 3-Kinases, Colorectal Neoplasms, Cyclin D1, Disease Models, Animal, Epistasis, Genetic, Female, Gene Expression, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microsatellite Instability, Phosphatidylinositol 3-Kinases, Tumor Burden, Wnt Signaling Pathway, beta Catenin
Added April 12, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms