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Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation.
Ho KH, Yang X, Osipovich AB, Cabrera O, Hayashi ML, Magnuson MA, Gu G, Kaverina I
(2020) Diabetes 69: 1936-1947
MeSH Terms: Animals, Cyclic AMP-Dependent Protein Kinases, Cyclin-Dependent Kinase 5, Glucose, Glycogen Synthase Kinase 3, Insulin Secretion, Insulin-Secreting Cells, Mice, Microtubules, Phosphorylation, Protein Kinase C, tau Proteins
Added July 2, 2020
2 Communities
4 Members
0 Resources
12 MeSH Terms
Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.
Cao Z, Singh B, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, Coffey RJ
(2019) Traffic 20: 357-368
MeSH Terms: A Kinase Anchor Proteins, Adaptor Proteins, Signal Transducing, Animals, Caco-2 Cells, Calcium-Binding Proteins, Cell Cycle Proteins, Cell Membrane, Cyclic AMP-Dependent Protein Kinases, Dinoprostone, Dogs, ErbB Receptors, HEK293 Cells, Humans, Madin Darby Canine Kidney Cells, Protein Transport, Signal Transduction, Transforming Growth Factor alpha, Vasoactive Intestinal Peptide
Added March 3, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
Second messenger signaling mechanisms of the brown adipocyte thermogenic program: an integrative perspective.
Shi F, Collins S
(2017) Horm Mol Biol Clin Investig 31:
MeSH Terms: Adipocytes, Beige, Adipocytes, Brown, Animals, Cyclic AMP-Dependent Protein Kinases, Cyclic GMP-Dependent Protein Kinases, Energy Metabolism, Gene Expression Regulation, Humans, Intracellular Space, Mechanistic Target of Rapamycin Complex 1, MicroRNAs, Natriuretic Agents, RNA, Long Noncoding, Receptors, Adrenergic, beta, Second Messenger Systems, Signal Transduction, Thermogenesis, Uncoupling Protein 1
Added September 26, 2018
0 Communities
2 Members
0 Resources
MeSH Terms
Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection.
Salina AC, Souza TP, Serezani CH, Medeiros AI
(2017) Innate Immun 23: 219-227
MeSH Terms: Animals, Apoptosis, Bacteriolysis, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Dinoprostone, Female, Homeostasis, Humans, Hydrogen Peroxide, Jurkat Cells, Macrophages, Alveolar, Phagocytosis, Pneumococcal Infections, Rats, Rats, Wistar, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Signal Transduction, Streptococcus pneumoniae
Added May 4, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.
Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S
(2016) J Clin Invest 126: 1704-16
MeSH Terms: 3T3-L1 Cells, Adaptor Proteins, Signal Transducing, Adipose Tissue, Brown, Adipose Tissue, White, Animals, Cyclic AMP-Dependent Protein Kinases, HEK293 Cells, Humans, Insulin, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Knockout, Multiprotein Complexes, Receptors, Adrenergic, beta, Regulatory-Associated Protein of mTOR, Ribosomal Protein S6 Kinases, 70-kDa, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, TOR Serine-Threonine Kinases, Uncoupling Protein 1
Added July 22, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.
Zoccal KF, Sorgi CA, Hori JI, Paula-Silva FW, Arantes EC, Serezani CH, Zamboni DS, Faccioli LH
(2016) Nat Commun 7: 10760
MeSH Terms: Animals, Arachidonate 5-Lipoxygenase, Blotting, Western, Carrier Proteins, Celecoxib, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Cyclooxygenase Inhibitors, Dinoprostone, In Vitro Techniques, Indoles, Indomethacin, Inflammasomes, Interleukin-1beta, Leukotriene B4, Lipoxygenase Inhibitors, Macrophages, Macrophages, Peritoneal, Mice, Mice, Knockout, NF-kappa B, NLR Family, Pyrin Domain-Containing 3 Protein, Phosphoproteins, Prostaglandin Antagonists, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Reverse Transcriptase Polymerase Chain Reaction, Scorpion Stings, Scorpion Venoms, Scorpions, Xanthones
Added May 4, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms
An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition.
Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC
(2015) Cell Rep 11: 43-50
MeSH Terms: Animals, Cyclic AMP-Dependent Protein Kinases, Cyclic Nucleotide Phosphodiesterases, Type 4, Hedgehog Proteins, Phosphodiesterase 4 Inhibitors, Pyrimidinones, Receptors, G-Protein-Coupled, Signal Transduction, Small Molecule Libraries, Smoothened Receptor, Thiophenes, Transcriptional Activation, Zebrafish, Zebrafish Proteins
Added April 5, 2015
1 Communities
3 Members
0 Resources
14 MeSH Terms
MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation.
Wang Z, Brandt S, Medeiros A, Wang S, Wu H, Dent A, Serezani CH
(2015) PLoS One 10: e0115855
MeSH Terms: Acetylcysteine, Animals, Cell Polarity, Cyclic AMP-Dependent Protein Kinases, Dinoprostone, Erythromycin, Female, Gene Silencing, Homeostasis, Macrophage Activation, Macrophages, Mice, Mice, Knockout, MicroRNAs, STAT3 Transcription Factor, Suppressor of Cytokine Signaling 1 Protein, Suppressor of Cytokine Signaling Proteins
Added May 4, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms
Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
Elliott AD, Ustione A, Piston DW
(2015) Am J Physiol Endocrinol Metab 308: E130-43
MeSH Terms: Animals, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Flow Cytometry, Glucagon, Glucagon-Secreting Cells, Glucose, Humans, Insulin, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Microscopy, Confocal, Signal Transduction, Somatostatin
Added January 20, 2015
0 Communities
2 Members
0 Resources
16 MeSH Terms
PACAP induces plasticity at autonomic synapses by nAChR-dependent NOS1 activation and AKAP-mediated PKA targeting.
Jayakar SS, Pugh PC, Dale Z, Starr ER, Cole S, Margiotta JF
(2014) Mol Cell Neurosci 63: 1-12
MeSH Terms: A Kinase Anchor Proteins, Animals, Autonomic Nervous System, Calcium, Cells, Cultured, Chick Embryo, Cyclic AMP-Dependent Protein Kinases, Neuronal Plasticity, Neurons, Nitric Oxide, Nitric Oxide Synthase Type I, Pituitary Adenylate Cyclase-Activating Polypeptide, Protein Binding, Receptors, Nicotinic, Synapses
Added June 2, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms