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Results: 1 to 10 of 14

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Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability.
Wanzek K, Schwindt E, Capra JA, Paeschke K
(2017) Nucleic Acids Res 45: 7796-7806
MeSH Terms: Binding Sites, Cell Cycle, Cullin Proteins, DNA Helicases, DNA Replication, DNA, Fungal, Endodeoxyribonucleases, Exodeoxyribonucleases, G-Quadruplexes, GC Rich Sequence, Genomic Instability, Models, Biological, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
A genome-wide association study of anorexia nervosa.
Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM, Southam L, Rayner NW, Tachmazidou I, Klump KL, Treasure J, Lewis CM, Schmidt U, Tozzi F, Kiezebrink K, Hebebrand J, Gorwood P, Adan RA, Kas MJ, Favaro A, Santonastaso P, Fernández-Aranda F, Gratacos M, Rybakowski F, Dmitrzak-Weglarz M, Kaprio J, Keski-Rahkonen A, Raevuori A, Van Furth EF, Slof-Op 't Landt MC, Hudson JI, Reichborn-Kjennerud T, Knudsen GP, Monteleone P, Kaplan AS, Karwautz A, Hakonarson H, Berrettini WH, Guo Y, Li D, Schork NJ, Komaki G, Ando T, Inoko H, Esko T, Fischer K, Männik K, Metspalu A, Baker JH, Cone RD, Dackor J, DeSocio JE, Hilliard CE, O'Toole JK, Pantel J, Szatkiewicz JP, Taico C, Zerwas S, Trace SE, Davis OS, Helder S, Bühren K, Burghardt R, de Zwaan M, Egberts K, Ehrlich S, Herpertz-Dahlmann B, Herzog W, Imgart H, Scherag A, Scherag S, Zipfel S, Boni C, Ramoz N, Versini A, Brandys MK, Danner UN, de Kovel C, Hendriks J, Koeleman BP, Ophoff RA, Strengman E, van Elburg AA, Bruson A, Clementi M, Degortes D, Forzan M, Tenconi E, Docampo E, Escaramís G, Jiménez-Murcia S, Lissowska J, Rajewski A, Szeszenia-Dabrowska N, Slopien A, Hauser J, Karhunen L, Meulenbelt I, Slagboom PE, Tortorella A, Maj M, Dedoussis G, Dikeos D, Gonidakis F, Tziouvas K, Tsitsika A, Papezova H, Slachtova L, Martaskova D, Kennedy JL, Levitan RD, Yilmaz Z, Huemer J, Koubek D, Merl E, Wagner G, Lichtenstein P, Breen G, Cohen-Woods S, Farmer A, McGuffin P, Cichon S, Giegling I, Herms S, Rujescu D, Schreiber S, Wichmann HE, Dina C, Sladek R, Gambaro G, Soranzo N, Julia A, Marsal S, Rabionet R, Gaborieau V, Dick DM, Palotie A, Ripatti S, Widén E, Andreassen OA, Espeseth T, Lundervold A, Reinvang I, Steen VM, Le Hellard S, Mattingsdal M, Ntalla I, Bencko V, Foretova L, Janout V, Navratilova M, Gallinger S, Pinto D, Scherer SW, Aschauer H, Carlberg L, Schosser A, Alfredsson L, Ding B, Klareskog L, Padyukov L, Courtet P, Guillaume S, Jaussent I, Finan C, Kalsi G, Roberts M, Logan DW, Peltonen L, Ritchie GR, Barrett JC, Wellcome Trust Case Control Consortium 3, Estivill X, Hinney A, Sullivan PF, Collier DA, Zeggini E, Bulik CM
(2014) Mol Psychiatry 19: 1085-94
MeSH Terms: Anorexia Nervosa, Asian Continental Ancestry Group, Calcineurin, Carrier Proteins, Case-Control Studies, Cullin Proteins, European Continental Ancestry Group, Female, Genome-Wide Association Study, Guanine Nucleotide Exchange Factors, Humans, Japan, Male, Meta-Analysis as Topic, Nuclear Proteins, Polymorphism, Single Nucleotide
Added May 27, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP
(2012) Nature 482: 98-102
MeSH Terms: Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Base Sequence, Blood Pressure, Carrier Proteins, Cohort Studies, Cullin Proteins, Electrolytes, Exons, Female, Gene Expression Profiling, Genes, Dominant, Genes, Recessive, Genotype, Homeostasis, Humans, Hydrogen-Ion Concentration, Hypertension, Male, Mice, Microfilament Proteins, Models, Molecular, Molecular Sequence Data, Mutation, Phenotype, Potassium, Pseudohypoaldosteronism, Sodium Chloride, Water-Electrolyte Imbalance
Added February 25, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Cysteine-based regulation of the CUL3 adaptor protein Keap1.
Sekhar KR, Rachakonda G, Freeman ML
(2010) Toxicol Appl Pharmacol 244: 21-6
MeSH Terms: Adaptor Proteins, Signal Transducing, Amino Acid Motifs, Animals, Cullin Proteins, Cysteine, Cytoskeletal Proteins, Gene Expression Regulation, Humans, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Oxidation-Reduction, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Protein Structure, Tertiary, Structure-Activity Relationship, Sulfhydryl Compounds, Transcriptional Activation, Ubiquitination
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans.
Choe KP, Przybysz AJ, Strange K
(2009) Mol Cell Biol 29: 2704-15
MeSH Terms: Amino Acid Sequence, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Nucleus, Cullin Proteins, DNA-Binding Proteins, Forkhead Transcription Factors, Gene Expression Regulation, Glutathione Transferase, Humans, Isoenzymes, MAP Kinase Kinase 4, Molecular Sequence Data, Phylogeny, Proteasome Endopeptidase Complex, Receptor, Insulin, Recombinant Fusion Proteins, Repetitive Sequences, Amino Acid, Repressor Proteins, Sequence Alignment, Signal Transduction, Stress, Physiological, Transcription Factors, Two-Hybrid System Techniques
Added December 5, 2013
1 Communities
0 Members
0 Resources
25 MeSH Terms
A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron.
Plesca D, Mazumder S, Gama V, Matsuyama S, Almasan A
(2008) J Biol Chem 283: 30796-803
MeSH Terms: Antigens, Nuclear, Apoptosis, Boronic Acids, Bortezomib, Caspases, Cell Cycle Proteins, Cell Line, Tumor, Cullin Proteins, Cyclin E, DNA-Binding Proteins, F-Box Proteins, F-Box-WD Repeat-Containing Protein 7, Half-Life, Hematologic Neoplasms, Humans, Isoenzymes, Ku Autoantigen, Neoplasm Proteins, Phosphorylation, Protease Inhibitors, Proteasome Endopeptidase Complex, Proto-Oncogene Proteins c-mdm2, Pyrazines, S-Phase Kinase-Associated Proteins, Ubiquitin-Protein Ligases, Ubiquitination, bcl-2-Associated X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
27 MeSH Terms
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H
(2008) Mol Cell Biol 28: 5874-85
MeSH Terms: Cell Line, Checkpoint Kinase 2, Cullin Proteins, DNA Damage, DNA Repair, Humans, Phosphorylation, Protein-Serine-Threonine Kinases, Radiation, Ionizing, Serine, Signal Transduction, Ubiquitin-Protein Ligases, Ubiquitination
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.
Rachakonda G, Xiong Y, Sekhar KR, Stamer SL, Liebler DC, Freeman ML
(2008) Chem Res Toxicol 21: 705-10
MeSH Terms: Animals, COS Cells, Cell Cycle Proteins, Cell Line, Tumor, Cells, Cultured, Chlorocebus aethiops, Circular Dichroism, Cullin Proteins, Cysteine, DNA, Recombinant, Humans, Immunoprecipitation, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, Kinetics, Mass Spectrometry, Recombinant Proteins
Added March 5, 2014
0 Communities
2 Members
0 Resources
17 MeSH Terms
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
Gao L, Wang J, Sekhar KR, Yin H, Yared NF, Schneider SN, Sasi S, Dalton TP, Anderson ME, Chan JY, Morrow JD, Freeman ML
(2007) J Biol Chem 282: 2529-37
MeSH Terms: Animals, Cell Cycle Proteins, Cell Line, Cullin Proteins, Fatty Acids, Omega-3, Gene Expression Regulation, Genes, Reporter, Humans, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, Mice, Molecular Structure, NF-E2-Related Factor 2, Oxidation-Reduction, Oxidative Stress, Transcriptional Activation
Added March 5, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA, Lock K, Yenamandra A, Cortez D
(2006) Mol Cell Biol 26: 7977-90
MeSH Terms: Animals, Ataxia Telangiectasia Mutated Proteins, Cell Cycle, Cell Cycle Proteins, Cell Line, Chromosomes, Human, Cullin Proteins, DNA Damage, DNA Repair, DNA Replication, DNA-Binding Proteins, Genes, cdc, Genome, Human, Genomic Instability, Humans, Protein Subunits, Protein-Serine-Threonine Kinases, RNA, Small Interfering, S-Phase Kinase-Associated Proteins, Tumor Suppressor Proteins, Xeroderma Pigmentosum, Xeroderma Pigmentosum Group A Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms