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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 80

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Structural analyses of sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.
Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI
(2017) J Biol Chem 292: 6728-6743
MeSH Terms: Animals, Antifungal Agents, Azoles, Candida albicans, Crystallization, Fungal Proteins, Heme, Humans, Kinetics, Ligands, Microbial Sensitivity Tests, Protein Binding, Protein Conformation, Protons, Rats, Sterol 14-Demethylase, Sterols
Added March 14, 2018
0 Communities
3 Members
0 Resources
17 MeSH Terms
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.
Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR
(2014) Nat Commun 5: 5209
MeSH Terms: Animals, Cell Differentiation, Chick Embryo, Coculture Techniques, Crystallization, Extracellular Matrix Proteins, Humans, Ligands, Mice, Neurogenesis, Neurons, Protein Binding, Protein Structure, Tertiary, Proteoglycans, Receptor, trkC, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Signal Transduction, Synapses
Added February 2, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.
Luka Z, Pakhomova S, Loukachevitch LV, Newcomer ME, Wagner C
(2014) Biochem Biophys Res Commun 449: 392-8
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Catalytic Domain, Crystallization, Crystallography, X-Ray, Dimethylglycine Dehydrogenase, Humans, Kinetics, Mitochondrial Proteins, Models, Molecular, Molecular Sequence Data, Rats, Sarcosine, Tetrahydrofolates
Added January 20, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
A structure-specific nucleic acid-binding domain conserved among DNA repair proteins.
Mason AC, Rambo RP, Greer B, Pritchett M, Tainer JA, Cortez D, Eichman BF
(2014) Proc Natl Acad Sci U S A 111: 7618-23
MeSH Terms: Adenosine Triphosphate, Animals, Chromatography, Affinity, Chromatography, Agarose, Chromatography, Gel, Chromatography, Ion Exchange, Cloning, Molecular, Crystallization, DNA Helicases, DNA Repair, Hydrolysis, Likelihood Functions, Mice, Models, Molecular, Nucleic Acids, Protein Structure, Tertiary, Scattering, Small Angle, X-Ray Diffraction
Added May 19, 2014
1 Communities
2 Members
0 Resources
18 MeSH Terms
Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP.
Balotra S, Newman J, French NG, Briggs LJ, Peat TS, Scott C
(2014) Acta Crystallogr F Struct Biol Commun 70: 310-5
MeSH Terms: Allophanate Hydrolase, Amidohydrolases, Bacterial Proteins, Crystallization, Crystallography, X-Ray, Enzyme Stability, Proteolysis, Pseudomonas, Sequence Analysis, Protein, Trypsin
Added March 20, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A.
Frank AO, Vangamudi B, Feldkamp MD, Souza-Fagundes EM, Luzwick JW, Cortez D, Olejniczak ET, Waterson AG, Rossanese OW, Chazin WJ, Fesik SW
(2014) J Med Chem 57: 2455-61
MeSH Terms: Alanine, Amino Acid Sequence, Cell Line, Crystallization, Crystallography, X-Ray, DNA, Single-Stranded, Drug Discovery, Electrophoretic Mobility Shift Assay, Fluorescence Polarization, Magnetic Resonance Spectroscopy, Microscopy, Fluorescence, Models, Molecular, Molecular Sequence Data, Penetrance, Peptides, Protein Conformation, Replication Protein A, Structure-Activity Relationship, Tumor Suppressor Protein p53
Added March 11, 2014
0 Communities
4 Members
0 Resources
19 MeSH Terms
Self-association of arrestin family members.
Chen Q, Zhuo Y, Kim M, Hanson SM, Francis DJ, Vishnivetskiy SA, Altenbach C, Klug CS, Hubbell WL, Gurevich VV
(2014) Handb Exp Pharmacol 219: 205-23
MeSH Terms: Animals, Arrestins, Crystallization, Humans, Phytic Acid, Protein Multimerization, Retinal Cone Photoreceptor Cells, Retinal Rod Photoreceptor Cells
Added February 12, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.
Red Brewer M, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W
(2013) Proc Natl Acad Sci U S A 110: E3595-604
MeSH Terms: Animals, Crystallization, Dimerization, ErbB Receptors, HEK293 Cells, Humans, Immunoblotting, Immunoprecipitation, Lung Neoplasms, Mice, Models, Molecular, Mutation, Missense, NIH 3T3 Cells, Protein Conformation, Receptor, ErbB-2
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein.
Feldkamp MD, Frank AO, Kennedy JP, Patrone JD, Vangamudi B, Waterson AG, Fesik SW, Chazin WJ
(2013) Biochemistry 52: 6515-24
MeSH Terms: Adaptor Proteins, Signal Transducing, Crystallization, Crystallography, X-Ray, DNA-Binding Proteins, Fluorescence Polarization, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Protein Interaction Domains and Motifs, Replication Protein A, Static Electricity
Added March 7, 2014
0 Communities
3 Members
0 Resources
10 MeSH Terms
Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides.
Li F, Xia Y, Meiler J, Ferguson-Miller S
(2013) Biochemistry 52: 5884-99
MeSH Terms: Amino Acid Sequence, Apoptosis, Binding, Competitive, Carrier Proteins, Cholesterol, Cryoelectron Microscopy, Crystallization, Isoquinolines, Membrane Proteins, Mitochondrial Membranes, Protein Multimerization, Protoporphyrins, Receptors, GABA-A, Rhodobacter sphaeroides, Sequence Alignment
Added January 24, 2015
1 Communities
1 Members
0 Resources
15 MeSH Terms