Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes.
Li Z, Li Y, Overstreet JM, Chung S, Niu A, Fan X, Wang S, Wang Y, Zhang MZ, Harris RC
(2018) Diabetes 67
: 1847-1857MeSH Terms: Albuminuria, Animals, Biomarkers, Crosses, Genetic, Cytokines, Diabetes Mellitus, Type 2, Diabetic Nephropathies, ErbB Receptors, Erlotinib Hydrochloride, Fibrosis, Glomerulonephritis, Hypoglycemic Agents, Insulin Resistance, Kidney, Macrophages, Membrane Transport Modulators, Mice, Knockout, Mice, Mutant Strains, Nitric Oxide Synthase Type III, Oxidative Stress, Protein Kinase Inhibitors, T-Lymphocytes, Transforming Growth Factor alphaAdded November 9, 2018
23 MeSH Terms
Blocking TGF- and -Catenin Epithelial Crosstalk Exacerbates CKD.
Nlandu-Khodo S, Neelisetty S, Phillips M, Manolopoulou M, Bhave G, May L, Clark PE, Yang H, Fogo AB, Harris RC, Taketo MM, Lee E, Gewin LS
(2017) J Am Soc Nephrol 28
: 3490-3503MeSH Terms: Animals, Aristolochic Acids, Cell Nucleus, Collagen, Crosses, Genetic, Epithelium, Female, Gene Deletion, Kidney Failure, Chronic, Kidney Tubules, Proximal, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, Mice, Transgenic, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Transforming Growth Factor beta1, Wnt Proteins, beta CateninAdded July 18, 2017
22 MeSH Terms
The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.
Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM
(2016) Endocrinology 157
: 220-32MeSH Terms: Adipose Tissue, White, Adiposity, Animals, Cell Size, Crosses, Genetic, Diabetes Mellitus, Type 2, Diet, High-Fat, Insulin Resistance, Lipid Metabolism, Liver, Macrophage Activation, Male, Mice, Inbred C57BL, Mice, Knockout, Muscle, Skeletal, Necrosis, Non-alcoholic Fatty Liver Disease, Obesity, Panniculitis, Receptors, Prostaglandin E, EP3 Subtype, Weight GainAdded January 12, 2016
21 MeSH Terms
Global deletion of Ankrd1 results in a wound-healing phenotype associated with dermal fibroblast dysfunction.
Samaras SE, Almodóvar-García K, Wu N, Yu F, Davidson JM
(2015) Am J Pathol 185
: 96-109MeSH Terms: Adenoviridae, Animals, Cell Movement, Collagen, Crosses, Genetic, Exons, Female, Fibroblasts, Gels, Gene Deletion, Gene Expression Profiling, Genotype, Green Fluorescent Proteins, MAP Kinase Signaling System, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Muscle Proteins, Necrosis, Nuclear Proteins, Organ Size, Phenotype, Promoter Regions, Genetic, RNA, Recombination, Genetic, Repressor Proteins, Skin, Wound HealingAdded January 20, 2015
30 MeSH Terms
Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.
Gray RS, Wilm TP, Smith J, Bagnat M, Dale RM, Topczewski J, Johnson SL, Solnica-Krezel L
(2014) Dev Biol 386
: 72-85MeSH Terms: Alleles, Animals, Collagen Type VIII, Crosses, Genetic, Gene Expression Regulation, Developmental, In Situ Hybridization, Meiosis, Microscopy, Confocal, Microscopy, Electron, Transmission, Mutation, Notochord, Osteoblasts, Protein-Lysine 6-Oxidase, Spine, Time Factors, ZebrafishAdded March 20, 2014
16 MeSH Terms
Generation of a tenascin-C-CreER2 knockin mouse line for conditional DNA recombination in renal medullary interstitial cells.
He W, Xie Q, Wang Y, Chen J, Zhao M, Davis LS, Breyer MD, Gu G, Hao CM
(2013) PLoS One 8
: e79839MeSH Terms: Animals, Aquaporin 1, Aquaporin 2, Crosses, Genetic, Cyclooxygenase 2, Female, Fibroblasts, Founder Effect, Gene Expression Regulation, Gene Knock-In Techniques, Genes, Reporter, Green Fluorescent Proteins, Integrases, Kidney Medulla, Lac Operon, Male, Mice, Mice, Transgenic, Promoter Regions, Genetic, Tamoxifen, Tenascin, TransgenesAdded January 10, 2014
22 MeSH Terms
β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.
Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B
(2013) Diabetes 62
: 1527-36MeSH Terms: Animals, Crosses, Genetic, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Enzyme Induction, Exenatide, Glucose Clamp Technique, Hyperglycemia, Hypoglycemic Agents, Insulin, Insulin Secretion, Insulin-Secreting Cells, Kinetics, Mice, Mutant Proteins, Patch-Clamp Techniques, Peptides, Phosphorylation, Protein Processing, Post-Translational, Protein Subunits, Second Messenger Systems, Up-Regulation, VenomsAdded February 12, 2015
23 MeSH Terms
Absence of Ca2+-stimulated adenylyl cyclases leads to reduced synaptic plasticity and impaired experience-dependent fear memory.
Wieczorek L, Majumdar D, Wills TA, Hu L, Winder DG, Webb DJ, Muglia LJ
(2012) Transl Psychiatry 2
: e126MeSH Terms: Adenylyl Cyclases, Animals, Calcium, Crosses, Genetic, Fear, Gene-Environment Interaction, Hippocampus, Long-Term Potentiation, Membrane Glycoproteins, Mental Recall, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Tissue Proteins, Neurogenesis, Neuronal Plasticity, Prosencephalon, SynapsesAdded May 19, 2014
18 MeSH Terms
Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK
(2012) Proc Natl Acad Sci U S A 109
: 12105-10MeSH Terms: Animals, Autoantibodies, Autoimmunity, B-Lymphocytes, Regulatory, Blotting, Western, Crosses, Genetic, DNA Primers, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Hepatitis A Virus Cellular Receptor 1, Interferon-gamma, Interleukin-10, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Mucins, Mutagenesis, Protein Structure, Tertiary, Reverse Transcriptase Polymerase Chain Reaction, T-LymphocytesAdded September 12, 2016
21 MeSH Terms
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin.
Teta M, Choi YS, Okegbe T, Wong G, Tam OH, Chong MM, Seykora JT, Nagy A, Littman DR, Andl T, Millar SE
(2012) Development 139
: 1405-16MeSH Terms: Animals, Crosses, Genetic, DEAD-box RNA Helicases, Epidermal Cells, Gene Deletion, Hair Follicle, Mice, MicroRNAs, Microscopy, Fluorescence, Phenotype, Ribonuclease III, Signal Transduction, Skin, Stem Cells, Wound HealingAdded January 30, 2013
15 MeSH Terms