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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 14

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SRChing for the substrates of Src.
Reynolds AB, Kanner SB, Bouton AH, Schaller MD, Weed SA, Flynn DC, Parsons JT
(2014) Oncogene 33: 4537-47
MeSH Terms: Animals, Catenins, Cell Transformation, Neoplastic, Cortactin, Crk-Associated Substrate Protein, Focal Adhesion Kinase 1, Gene Expression Regulation, Neoplastic, Humans, Mice, Microfilament Proteins, Neoplasms, Phosphorylation, Proteome, src-Family Kinases
Added March 28, 2014
1 Communities
1 Members
0 Resources
14 MeSH Terms
Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB
(2012) J Clin Invest 122: 674-92
MeSH Terms: Adolescent, Adult, Aged, Animals, Cell Line, Crk-Associated Substrate Protein, Female, Focal Adhesion Protein-Tyrosine Kinases, Humans, Kidney Diseases, Kidney Glomerulus, Membrane Proteins, Mice, Mice, Knockout, Middle Aged, Phosphatidylinositol 3-Kinases, Podocytes, Proto-Oncogene Proteins c-crk, Pseudopodia, Rats, Rats, Sprague-Dawley, Recombinant Fusion Proteins, Signal Transduction, Young Adult
Added January 20, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness.
Janoštiak R, Tolde O, Brůhová Z, Novotný M, Hanks SK, Rösel D, Brábek J
(2011) Mol Biol Cell 22: 4256-67
MeSH Terms: Animals, Cell Adhesion Molecules, Cell Line, Transformed, Cell Line, Tumor, Cell Movement, Cell Transformation, Neoplastic, Crk-Associated Substrate Protein, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesions, Green Fluorescent Proteins, Humans, Mice, Mutation, Neoplasm Invasiveness, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 12, Signal Transduction, Tyrosine, src Homology Domains
Added January 20, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration.
Meenderink LM, Ryzhova LM, Donato DM, Gochberg DF, Kaverina I, Hanks SK
(2010) PLoS One 5: e13412
MeSH Terms: Animals, Cell Movement, Crk-Associated Substrate Protein, Focal Adhesions, Mice, Mice, Knockout, Phosphorylation, Signal Transduction, Substrate Specificity, Tyrosine, src-Family Kinases
Added December 10, 2013
0 Communities
2 Members
0 Resources
11 MeSH Terms
Dynamics and mechanism of p130Cas localization to focal adhesions.
Donato DM, Ryzhova LM, Meenderink LM, Kaverina I, Hanks SK
(2010) J Biol Chem 285: 20769-79
MeSH Terms: Animals, Antibodies, Monoclonal, Cell Movement, Crk-Associated Substrate Protein, Fibroblasts, Focal Adhesions, Genes, Reporter, Genetic Variation, Immunoblotting, Luminescent Proteins, Mice, Paxillin, Phosphorylation, Plasmids, Polymerase Chain Reaction, Substrate Specificity, Wound Healing, src-Family Kinases
Added December 10, 2013
0 Communities
2 Members
0 Resources
18 MeSH Terms
Extracellular matrix rigidity promotes invadopodia activity.
Alexander NR, Branch KM, Parekh A, Clark ES, Iwueke IC, Guelcher SA, Weaver AM
(2008) Curr Biol 18: 1295-1299
MeSH Terms: Actin Cytoskeleton, Azepines, Cell Line, Tumor, Cell Surface Extensions, Crk-Associated Substrate Protein, Enzyme Inhibitors, Extracellular Matrix, Focal Adhesion Kinase 1, Gelatin, Heterocyclic Compounds, 4 or More Rings, Humans, Integrins, Myosin Type II, Myosin-Light-Chain Kinase, Naphthalenes, Signal Transduction
Added March 5, 2014
2 Communities
3 Members
0 Resources
16 MeSH Terms
Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model.
Park SI, Zhang J, Phillips KA, Araujo JC, Najjar AM, Volgin AY, Gelovani JG, Kim SJ, Wang Z, Gallick GE
(2008) Cancer Res 68: 3323-33
MeSH Terms: Animals, Antineoplastic Agents, Cell Movement, Cell Proliferation, Crk-Associated Substrate Protein, Dasatinib, Disease Models, Animal, Drug Delivery Systems, Focal Adhesion Kinase 1, Humans, Lymphatic Metastasis, Male, Mice, Mice, Nude, Prostatic Neoplasms, Pyrimidines, Thiazoles, Tumor Burden, Tumor Cells, Cultured, Tyrosine, Xenograft Model Antitumor Assays, src-Family Kinases
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Distinct roles for p107 and p130 in Rb-independent cellular senescence.
Lehmann BD, Brooks AM, Paine MS, Chappell WH, McCubrey JA, Terrian DM
(2008) Cell Cycle 7: 1262-8
MeSH Terms: Carcinoma, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Cellular Senescence, Crk-Associated Substrate Protein, Cyclin-Dependent Kinase Inhibitor p27, DNA Damage, Down-Regulation, Genes, cdc, Humans, Male, Prostatic Neoplasms, Radiation, Retinoblastoma Protein, Retinoblastoma-Like Protein p107, Tumor Suppressor Proteins
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling.
Kim W, Seok Kang Y, Soo Kim J, Shin NY, Hanks SK, Song WK
(2008) Mol Biol Cell 19: 2135-46
MeSH Terms: Animals, Cell Cycle, Cell Nucleus, Cell Proliferation, Cells, Cultured, Crk-Associated Substrate Protein, Extracellular Matrix, Humans, Integrins, Mice, Phosphorylation, Phosphotyrosine, Protein Binding, Protein Transport, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad3 Protein, Transcription, Genetic, Transforming Growth Factor beta
Added January 20, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
p130CAS is required for netrin signaling and commissural axon guidance.
Liu G, Li W, Gao X, Li X, Jürgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan KL, Rao Y
(2007) J Neurosci 27: 957-68
MeSH Terms: Animals, Axons, Cell Line, Cells, Cultured, Chick Embryo, Crk-Associated Substrate Protein, Female, Humans, MAP Kinase Signaling System, Mice, Nerve Growth Factors, Netrin-1, Pregnancy, Tumor Suppressor Proteins, rac1 GTP-Binding Protein
Added January 20, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms