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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 21

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Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs.
Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 1869-72
MeSH Terms: Allosteric Regulation, Central Nervous System, Coumarins, Dose-Response Relationship, Drug, Drug Discovery, Drug Stability, Furans, Humans, Isoindoles, Molecular Structure, Phthalimides, Receptors, Metabotropic Glutamate, Structure-Activity Relationship, Substrate Specificity
Added April 6, 2017
0 Communities
2 Members
0 Resources
14 MeSH Terms
Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool.
Garcia-Barrantes PM, Cho HP, Metts AM, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 751-756
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Coumarins, Furans, Half-Life, Heterocyclic Compounds, Humans, Protein Binding, Rats, Receptors, Metabotropic Glutamate, Schizophrenia, Structure-Activity Relationship
Added February 18, 2016
0 Communities
2 Members
0 Resources
13 MeSH Terms
Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core.
Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
(2015) Bioorg Med Chem Lett 25: 5107-10
MeSH Terms: Allosteric Regulation, Animals, Brain, Coumarins, Furans, Humans, Microsomes, Liver, Phthalimides, Rats, Receptors, Metabotropic Glutamate, Stereoisomerism, Structure-Activity Relationship
Added February 18, 2016
0 Communities
2 Members
0 Resources
12 MeSH Terms
Toxicity studies of coumarin 6-encapsulated polystyrene nanospheres conjugated with peanut agglutinin and poly(N-vinylacetamide) as a colonoscopic imaging agent in rats.
Sakuma S, Kumagai H, Shimosato M, Kitamura T, Mohri K, Ikejima T, Hiwatari K, Koike S, Tobita E, McClure R, Gore JC, Pham W
(2015) Nanomedicine 11: 1227-36
MeSH Terms: Acetamides, Animals, Body Weight, CHO Cells, Caco-2 Cells, Colon, Colonoscopy, Colorectal Neoplasms, Coumarins, Cricetulus, Drinking, Eating, Fluorescent Dyes, Humans, Male, Nanospheres, Peanut Agglutinin, Polystyrenes, Polyvinyls, Rats, Rectum, Thiazoles
Added February 15, 2016
0 Communities
2 Members
0 Resources
22 MeSH Terms
High-throughput fluorescence assay of cytochrome P450 3A4.
Cheng Q, Guengerich FP
(2013) Methods Mol Biol 987: 157-62
MeSH Terms: Coumarins, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Enzyme Assays, Humans, Inhibitory Concentration 50, Ketoconazole, Spectrometry, Fluorescence
Added March 26, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Multifunctional nanobeacon for imaging Thomsen-Friedenreich antigen-associated colorectal cancer.
Kumagai H, Pham W, Kataoka M, Hiwatari K, McBride J, Wilson KJ, Tachikawa H, Kimura R, Nakamura K, Liu EH, Gore JC, Sakuma S
(2013) Int J Cancer 132: 2107-17
MeSH Terms: Animals, Antigens, Tumor-Associated, Carbohydrate, Blotting, Western, Case-Control Studies, Colon, Colorectal Neoplasms, Coumarins, Diagnostic Imaging, Fluorescent Dyes, Humans, Immunoenzyme Techniques, Male, Mice, Mice, Transgenic, Nanospheres, Peanut Agglutinin, Polystyrenes, RNA, Messenger, Real-Time Polymerase Chain Reaction, Rectum, Reverse Transcriptase Polymerase Chain Reaction, Surface Properties, Thiazoles, Tissue Distribution, Tumor Cells, Cultured
Added March 7, 2014
0 Communities
3 Members
0 Resources
25 MeSH Terms
Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective.
Sakuma S, Yamashita S, Hiwatari K, Hoffman RM, Pham W
(2011) Curr Drug Discov Technol 8: 367-78
MeSH Terms: Acetamides, Animals, Colonoscopy, Colorectal Neoplasms, Coumarins, Drug Delivery Systems, Fluorescent Dyes, Humans, Nanospheres, Peanut Agglutinin, Polystyrenes, Polyvinyls, Thiazoles
Added May 27, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.
Pantel J, Williams SY, Mi D, Sebag J, Corbin JD, Weaver CD, Cone RD
(2011) Eur J Pharmacol 660: 139-47
MeSH Terms: Allosteric Regulation, Cyclic AMP, Drug Evaluation, Preclinical, Furocoumarins, HEK293 Cells, High-Throughput Screening Assays, Humans, Luminescent Measurements, Phosphodiesterase Inhibitors, Pilot Projects, Receptor, Melanocortin, Type 4, Reproducibility of Results, Signal Transduction, Structure-Activity Relationship, Sulfonamides, Time Factors
Added December 10, 2013
0 Communities
3 Members
0 Resources
16 MeSH Terms
A potential of peanut agglutinin-immobilized fluorescent nanospheres as a safe candidate of diagnostic drugs for colonoscopy.
Sakuma S, Kataoka M, Higashino H, Yano T, Masaoka Y, Yamashita S, Hiwatari K, Tachikawa H, Kimura R, Nakamura K, Kumagai H, Gore JC, Pham W
(2011) Eur J Pharm Sci 42: 340-7
MeSH Terms: Animals, Caco-2 Cells, Colon, Colonoscopy, Colorectal Neoplasms, Coumarins, Early Detection of Cancer, Female, Fluorescent Dyes, Humans, Indicators and Reagents, Intestinal Mucosa, Mice, Nanospheres, Peanut Agglutinin, Thiazoles
Added May 27, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Basal lamina secreted by MDCK cells has size- and charge-selective properties.
Ferrell N, Groszek J, Li L, Smith R, Butler RS, Zorman CA, Roy S, Fissell WH
(2011) Am J Physiol Renal Physiol 300: F86-90
MeSH Terms: Animals, Basement Membrane, Cells, Cultured, Coumarins, Dogs, Extracellular Matrix, Ficoll, Fluorescein-5-isothiocyanate, Glomerular Basement Membrane, Kidney Glomerulus, Static Electricity
Added August 21, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms