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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 12

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High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity.
McDonnell WJ, Koethe JR, Mallal SA, Pilkinton MA, Kirabo A, Ameka MK, Cottam MA, Hasty AH, Kennedy AJ
(2018) Diabetes 67: 2361-2376
MeSH Terms: Adipose Tissue, Animals, CD8-Positive T-Lymphocytes, Complementarity Determining Regions, Diet, High-Fat, Glucose Tolerance Test, Insulin Resistance, Liver, Male, Mice, Obesity, Prostaglandins
Added March 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.
Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR, Asokan M, Bailer RT, Bennici AK, Chen X, Doria-Rose NA, Druz A, Feng Y, Joyce MG, Louder MK, O'Dell S, Oliver C, Pancera M, Connors M, Hope TJ, Kepler TB, Wyatt RT, Ward AB, Georgiev IS, Kwong PD, Mascola JR, Binley JM
(2017) Immunity 46: 777-791.e10
MeSH Terms: Amino Acid Sequence, Antibodies, Neutralizing, B-Lymphocytes, Binding Sites, Complementarity Determining Regions, HIV Antibodies, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Models, Molecular, Peptide Fragments, Phylogeny, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Protein Multimerization, Vaccines, Virus-Like Particle, env Gene Products, Human Immunodeficiency Virus
Added March 14, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints.
Finn JA, Koehler Leman J, Willis JR, Cisneros A, Crowe JE, Meiler J
(2016) PLoS One 11: e0154811
MeSH Terms: Algorithms, Cluster Analysis, Complementarity Determining Regions, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Models, Molecular, Protein Conformation, Structure-Activity Relationship
Added April 8, 2017
1 Communities
2 Members
0 Resources
8 MeSH Terms
Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.
Willis JR, Finn JA, Briney B, Sapparapu G, Singh V, King H, LaBranche CC, Montefiori DC, Meiler J, Crowe JE
(2016) Proc Natl Acad Sci U S A 113: 4446-51
MeSH Terms: Amino Acid Substitution, Antibodies, Neutralizing, Blood Donors, Complementarity Determining Regions, Female, HIV Antibodies, HIV Envelope Protein gp120, HIV-1, Humans, Immunoglobulin Heavy Chains, Male, Mutation, Missense
Added May 4, 2016
1 Communities
2 Members
0 Resources
12 MeSH Terms
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
Willis JR, Sapparapu G, Murrell S, Julien JP, Singh V, King HG, Xia Y, Pickens JA, LaBranche CC, Slaughter JC, Montefiori DC, Wilson IA, Meiler J, Crowe JE
(2015) J Clin Invest 125: 2523-31
MeSH Terms: Complementarity Determining Regions, HIV Antibodies, HIV Envelope Protein gp160, HIV-1, Humans, Models, Molecular, Protein Structure, Tertiary, Software
Added January 26, 2016
0 Communities
1 Members
0 Resources
8 MeSH Terms
Tissue-specific expressed antibody variable gene repertoires.
Briney BS, Willis JR, Finn JA, McKinney BA, Crowe JE
(2014) PLoS One 9: e100839
MeSH Terms: Adolescent, Adult, Antibodies, Bone Marrow, Cluster Analysis, Complementarity Determining Regions, DNA, Demography, Gene Expression Regulation, Germ Cells, High-Throughput Nucleotide Sequencing, Humans, Immunoglobulin Variable Region, Lymphoid Tissue, Middle Aged, Mucous Membrane, Mutation, Mutation Rate, Organ Specificity, RNA, Somatic Hypermutation, Immunoglobulin, V(D)J Recombination, Young Adult
Added February 2, 2015
0 Communities
1 Members
0 Resources
23 MeSH Terms
Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire.
Briney BS, Willis JR, Hicar MD, Thomas JW, Crowe JE
(2012) Immunology 137: 56-64
MeSH Terms: Amino Acid Sequence, Antibodies, Antibody Formation, B-Lymphocytes, Base Sequence, Complementarity Determining Regions, Gene Frequency, Genetic Variation, High-Throughput Nucleotide Sequencing, Humans, Immunoglobulin Variable Region, Sequence Alignment, Sequence Analysis, DNA, V(D)J Recombination
Added November 6, 2013
1 Communities
1 Members
0 Resources
14 MeSH Terms
Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes.
Briney BS, Willis JR, Crowe JE
(2012) PLoS One 7: e36750
MeSH Terms: Complementarity Determining Regions, Female, HIV Antibodies, HIV-1, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Joining Region, Male, Recombination, Genetic, Somatic Hypermutation, Immunoglobulin
Added August 6, 2012
0 Communities
1 Members
0 Resources
10 MeSH Terms
The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations.
Williams JV, Weitkamp JH, Blum DL, LaFleur BJ, Crowe JE
(2009) Mol Immunol 47: 407-14
MeSH Terms: Adult, Antibodies, Antibody Specificity, B-Lymphocytes, Cell Separation, Child, Complementarity Determining Regions, Flow Cytometry, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Light Chains, Immunoglobulin Variable Region, Infant, Infant, Newborn, Lymphocyte Count, Mutagenesis, Insertional, Mutation, Respiratory Syncytial Viruses, Species Specificity
Added February 27, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms
Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells.
Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE
(2007) Mol Immunol 44: 2173-83
MeSH Terms: Adult, Amino Acid Motifs, Animals, Antigens, CD19, B-Lymphocytes, Blood Donors, Cell Separation, Clone Cells, Complementarity Determining Regions, DNA Nucleotidylexotransferase, Exonucleases, Flow Cytometry, Gene Expression Regulation, Genes, Immunoglobulin, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Isotypes, Immunoglobulin Variable Region, Immunologic Memory, Mice, Mutation, Nucleotides, Tumor Necrosis Factor Receptor Superfamily, Member 7
Added August 6, 2012
0 Communities
1 Members
0 Resources
23 MeSH Terms