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Results: 1 to 10 of 18

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Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus.
Mike LA, Dutter BF, Stauff DL, Moore JL, Vitko NP, Aranmolate O, Kehl-Fie TE, Sullivan S, Reid PR, DuBois JL, Richardson AR, Caprioli RM, Sulikowski GA, Skaar EP
(2013) Proc Natl Acad Sci U S A 110: 8206-11
MeSH Terms: Animals, Anti-Bacterial Agents, Bacterial Proteins, Chromatography, High Pressure Liquid, Combinatorial Chemistry Techniques, Drug Design, Fermentation, Gene Expression Regulation, Bacterial, Glycolysis, Heme, Heme Oxygenase (Decyclizing), Inhibitory Concentration 50, Leukocytes, Mass Spectrometry, Mice, Microscopy, Electron, Scanning, Naphthols, Phagocytes, Pyrazoles, Staphylococcal Infections, Staphylococcus aureus
Added March 7, 2014
1 Communities
2 Members
0 Resources
21 MeSH Terms
A TALE nuclease architecture for efficient genome editing.
Miller JC, Tan S, Qiao G, Barlow KA, Wang J, Xia DF, Meng X, Paschon DE, Leung E, Hinkley SJ, Dulay GP, Hua KL, Ankoudinova I, Cost GJ, Urnov FD, Zhang HS, Holmes MC, Zhang L, Gregory PD, Rebar EJ
(2011) Nat Biotechnol 29: 143-8
MeSH Terms: Bacterial Proteins, Base Sequence, Binding Sites, Combinatorial Chemistry Techniques, DNA, Deoxyribonucleases, Type II Site-Specific, Genetic Engineering, Genome, Humans, K562 Cells, Molecular Sequence Data, Mutagenesis, Site-Directed, Receptors, CCR5, Transcription Factors, Vascular Endothelial Growth Factor A, Xanthomonas
Added June 6, 2012
1 Communities
0 Members
0 Resources
16 MeSH Terms
High-content profiling of cell responsiveness to graded substrates based on combinyatorially variant polymers.
Liu E, Treiser MD, Patel H, Sung HJ, Roskov KE, Kohn J, Becker ML, Moghe PV
(2009) Comb Chem High Throughput Screen 12: 646-55
MeSH Terms: Biological Assay, Cell Adhesion, Cell Line, Combinatorial Chemistry Techniques, Green Fluorescent Proteins, Humans, Microscopy, Atomic Force, Nylons, Tyrosine
Added May 29, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273.
Engers DW, Rodriguez AL, Williams R, Hammond AS, Venable D, Oluwatola O, Sulikowski GA, Conn PJ, Lindsley CW
(2009) ChemMedChem 4: 505-11
MeSH Terms: Combinatorial Chemistry Techniques, Molecular Structure, Oxadiazoles, Piperidines, Receptor, Metabotropic Glutamate 5, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added March 5, 2014
1 Communities
2 Members
0 Resources
7 MeSH Terms
Rapid, general access to chiral beta-fluoroamines and beta,beta-difluoroamines via organocatalysis.
Fadeyi OO, Lindsley CW
(2009) Org Lett 11: 943-6
MeSH Terms: Aldehydes, Amines, Catalysis, Combinatorial Chemistry Techniques, Hydrocarbons, Fluorinated, Molecular Structure, Stereoisomerism
Added March 5, 2014
1 Communities
1 Members
0 Resources
7 MeSH Terms
Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP.
Lee SP, Serezani CH, Medeiros AI, Ballinger MN, Peters-Golden M
(2009) J Immunol 182: 530-7
MeSH Terms: Animals, Cell Communication, Cells, Cultured, Combinatorial Chemistry Techniques, Cyclic AMP, Dinoprostone, Drug Synergism, Female, Leukotriene B4, Leukotriene D4, Macrophages, Alveolar, Phagocytosis, Rats, Rats, Wistar, Receptors, IgG, Signal Transduction, Up-Regulation
Added May 4, 2017
0 Communities
1 Members
0 Resources
17 MeSH Terms
Total synthesis of Ciliatamides A-C: stereochemical revision and the natural product-guided synthesis of unnatural analogs.
Lewis JA, Daniels RN, Lindsley CW
(2008) Org Lett 10: 4545-8
MeSH Terms: Biological Products, Combinatorial Chemistry Techniques, Lipopeptides, Molecular Structure, Oligopeptides, Stereoisomerism
Added March 5, 2014
1 Communities
1 Members
0 Resources
6 MeSH Terms
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function.
Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN, Ezzat S, Wrana J, Rose DR, Schachter H, Dennis JW, Schimmer AD
(2008) Cancer Res 68: 6688-97
MeSH Terms: Animals, Cell Movement, Cell Survival, Combinatorial Chemistry Techniques, Digitalis Glycosides, Enzyme Inhibitors, Glycopeptides, Glycosylation, Humans, Male, Mice, Mice, SCID, Neoplasms, Phytohemagglutinins, Polysaccharides, RNA, Small Interfering, Reverse Transcriptase Polymerase Chain Reaction, Sodium-Potassium-Exchanging ATPase, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Transfection, Tumor Cells, Cultured, Wound Healing
Added November 15, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.
Vila A, Tallman KA, Jacobs AT, Liebler DC, Porter NA, Marnett LJ
(2008) Chem Res Toxicol 21: 432-44
MeSH Terms: Aldehydes, Alkynes, Azides, Bacterial Proteins, Biotinylation, Combinatorial Chemistry Techniques, Cross-Linking Reagents, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Horseradish Peroxidase, Magnetic Resonance Spectroscopy, Proteins, Proteomics
Added March 5, 2014
0 Communities
3 Members
0 Resources
13 MeSH Terms
Application of combinatorial chemistry science on modern drug discovery.
Kennedy JP, Williams L, Bridges TM, Daniels RN, Weaver D, Lindsley CW
(2008) J Comb Chem 10: 345-54
MeSH Terms: Chemistry, Pharmaceutical, Combinatorial Chemistry Techniques, Drug Design, Drug Evaluation, Preclinical, Humans
Added March 5, 2014
1 Communities
2 Members
0 Resources
5 MeSH Terms