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Results: 1 to 10 of 176

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Collagen IV dysfunction in glomerular basement membrane diseases. I. Discovery of a COL4A3 variant in familial Goodpasture's and Alport diseases.
Pokidysheva EN, Seeger H, Pedchenko V, Chetyrkin S, Bergmann C, Abrahamson D, Cui ZW, Delpire E, Fervenza FC, Fidler AL, Fogo AB, Gaspert A, Grohmann M, Gross O, Haddad G, Harris RC, Kashtan C, Kitching AR, Lorenzen JM, McAdoo S, Pusey CD, Segelmark M, Simmons A, Voziyan PA, Wagner T, Wüthrich RP, Zhao MH, Boudko SP, Kistler AD, Hudson BG
(2021) J Biol Chem 296: 100590
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Collagen Type IV, Mice, Models, Molecular, Mutation, Nephritis, Hereditary, Protein Multimerization, Protein Structure, Quaternary, Signal Transduction
Added September 3, 2021
1 Communities
0 Members
0 Resources
MeSH Terms
The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus.
Chiusa M, Hu W, Liao HJ, Su Y, Borza CM, de Caestecker MP, Skrypnyk NI, Fogo AB, Pedchenko V, Li X, Zhang MZ, Hudson BG, Basak T, Vanacore RM, Zent R, Pozzi A
(2019) J Am Soc Nephrol 30: 1605-1624
MeSH Terms: Actins, Acute Kidney Injury, Animals, Biological Transport, Cell Line, Cell Nucleus, Chromatin, Collagen Type I, Collagen Type IV, Discoidin Domain Receptor 1, Humans, Kidney Tubules, Proximal, Male, Mice, Myosin Heavy Chains, Nuclear Localization Signals, Retinoblastoma-Binding Protein 4, SEC Translocation Channels, Transcription, Genetic
Added May 10, 2020
0 Communities
1 Members
0 Resources
19 MeSH Terms
Fibroblast-specific plasminogen activator inhibitor-1 depletion ameliorates renal interstitial fibrosis after unilateral ureteral obstruction.
Yao L, Wright MF, Farmer BC, Peterson LS, Khan AM, Zhong J, Gewin L, Hao CM, Yang HC, Fogo AB
(2019) Nephrol Dial Transplant 34: 2042-2050
MeSH Terms: Actins, Animals, Collagen Type I, Connective Tissue Growth Factor, Extracellular Matrix Proteins, Fibroblasts, Fibrosis, Kidney Diseases, Mice, Mice, Knockout, Nerve Tissue Proteins, Serpin E2, Transforming Growth Factor beta, Ureteral Obstruction
Added March 18, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking.
Howard AM, LaFever KS, Fenix AM, Scurrah CR, Lau KS, Burnette DT, Bhave G, Ferrell N, Page-McCaw A
(2019) J Cell Sci 132:
MeSH Terms: Animals, Basement Membrane, Collagen Type IV, Dextran Sulfate, Drosophila melanogaster, Extracellular Matrix, Female, Laminin, Male
Added March 27, 2019
0 Communities
2 Members
0 Resources
9 MeSH Terms
The altered mechanical phenotype of fetal fibroblasts hinders myofibroblast differentiation.
Jerrell RJ, Leih MJ, Parekh A
(2019) Wound Repair Regen 27: 29-38
MeSH Terms: Adult, Cell Differentiation, Cells, Cultured, Cicatrix, Collagen Type III, Extracellular Matrix, Female, Fetus, Fibroblasts, Gene Expression Regulation, Humans, Male, Myofibroblasts, Phenotype, Pregnancy, Transforming Growth Factor beta1, Wound Healing, Young Adult
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes.
McCall AS, Bhave G, Pedchenko V, Hess J, Free M, Little DJ, Baker TP, Pendergraft WF, Falk RJ, Olson SW, Hudson BG
(2018) J Am Soc Nephrol 29: 2619-2625
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Anti-Glomerular Basement Membrane Disease, Antibodies, Antineutrophil Cytoplasmic, Antibody Specificity, Autoantibodies, Autoantigens, Child, Cohort Studies, Collagen Type IV, Extracellular Matrix Proteins, Female, Glomerulonephritis, Hemorrhage, Humans, Lung Diseases, Male, Middle Aged, Models, Immunological, Peroxidase, Peroxidases, Young Adult
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
PD-1 up-regulation on CD4 T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.
Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP
(2018) Sci Transl Med 10:
MeSH Terms: Adult, Aged, Animals, Bleomycin, CD4-Positive T-Lymphocytes, Cell Proliferation, Collagen Type I, Disease Models, Animal, Female, Fibroblasts, Gene Expression Regulation, Humans, Idiopathic Pulmonary Fibrosis, Interleukin-17, Male, Mice, Middle Aged, Programmed Cell Death 1 Receptor, RNA, Messenger, STAT3 Transcription Factor, Sarcoidosis, Th17 Cells, Transforming Growth Factor beta1, Up-Regulation
Added March 26, 2019
0 Communities
1 Members
0 Resources
24 MeSH Terms
Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds.
Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F
(2018) Tissue Eng Part A 24: 1531-1544
MeSH Terms: Adult, Cells, Cultured, Chondrogenesis, Collagen Type II, Core Binding Factor Alpha 1 Subunit, Extracellular Matrix, Gene Knockdown Techniques, Genetic Engineering, Glycosaminoglycans, Humans, Mesenchymal Stem Cells, Minerals, Osteogenesis, Smad3 Protein, Tissue Engineering, Tissue Scaffolds, Transforming Growth Factor beta3
Added March 16, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution.
Fidler AL, Boudko SP, Rokas A, Hudson BG
(2018) J Cell Sci 131:
MeSH Terms: Animals, Cellular Microenvironment, Collagen Type IV, Evolution, Molecular, Extracellular Matrix, Protein Conformation, alpha-Helical
Added April 16, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms
The Role of Matrix Composition in the Mechanical Behavior of Bone.
Unal M, Creecy A, Nyman JS
(2018) Curr Osteoporos Rep 16: 205-215
MeSH Terms: Biomechanical Phenomena, Bone Density, Bone Matrix, Bone and Bones, Cancellous Bone, Collagen Type I, Fractures, Bone, Glycation End Products, Advanced, Humans, Minerals, Protein Processing, Post-Translational, Tropocollagen, Water
Added April 9, 2018
1 Communities
1 Members
0 Resources
13 MeSH Terms