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Results: 1 to 10 of 11

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Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice.
Lowe JS, Stroud DM, Yang T, Hall L, Atack TC, Roden DM
(2012) Cardiovasc Res 95: 300-7
MeSH Terms: Acetanilides, Action Potentials, Animals, Cnidarian Venoms, Disease Models, Animal, Electrocardiography, Female, Genetic Predisposition to Disease, Humans, Long QT Syndrome, Male, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, NAV1.5 Voltage-Gated Sodium Channel, Piperazines, Ranolazine, Risk Factors, Sex Factors, Tachycardia, Ventricular, Time Factors
Added June 26, 2014
0 Communities
2 Members
0 Resources
23 MeSH Terms
On the evolutionary origin of cyclooxygenase (COX) isozymes: characterization of marine invertebrate COX genes points to independent duplication events in vertebrate and invertebrate lineages.
Järving R, Järving I, Kurg R, Brash AR, Samel N
(2004) J Biol Chem 279: 13624-33
MeSH Terms: Amino Acid Sequence, Animals, COS Cells, Ciona intestinalis, Cnidaria, Cyclooxygenase 1, Cyclooxygenase 2, Evolution, Molecular, Gene Expression Regulation, Enzymologic, Introns, Isoenzymes, Molecular Sequence Data, Prostaglandin-Endoperoxide Synthases, RNA, Messenger
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla.
Schneider C, Manier ML, Hachey DL, Brash AR
(2002) Lipids 37: 217-21
MeSH Terms: Acetates, Acetylation, Animals, Chromatography, High Pressure Liquid, Cnidaria, Dinoprostone, Mass Spectrometry, Nuclear Magnetic Resonance, Biomolecular
Added December 10, 2013
0 Communities
3 Members
0 Resources
8 MeSH Terms
The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: molecular cloning and expression of a novel cyclooxygenase.
Valmsen K, Järving I, Boeglin WE, Varvas K, Koljak R, Pehk T, Brash AR, Samel N
(2001) Proc Natl Acad Sci U S A 98: 7700-5
MeSH Terms: Amino Acid Sequence, Animals, Cloning, Molecular, Cnidaria, Dinoprostone, Molecular Sequence Data, Prostaglandin-Endoperoxide Synthases, Prostaglandins, Prostaglandins A, Sequence Alignment, Stereoisomerism
Added December 10, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
Characterization of the coral allene oxide synthase active site with UV-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopy: evidence for tyrosinate ligation to the ferric enzyme heme iron.
Abraham BD, Sono M, Boutaud O, Shriner A, Dawson JH, Brash AR, Gaffney BJ
(2001) Biochemistry 40: 2251-9
MeSH Terms: Animals, Azides, Binding Sites, Catalase, Cattle, Circular Dichroism, Cnidaria, Cyanides, Electron Spin Resonance Spectroscopy, Ferric Compounds, Ferrous Compounds, Fluorides, Free Radicals, Heme, Intramolecular Oxidoreductases, Iron, Ligands, Peracetic Acid, Spectrophotometry, Ultraviolet, Tyrosine
Added December 10, 2013
0 Communities
2 Members
0 Resources
20 MeSH Terms
The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa.
Koljak R, Järving I, Kurg R, Boeglin WE, Varvas K, Valmsen K, Ustav M, Brash AR, Samel N
(2001) J Biol Chem 276: 7033-40
MeSH Terms: Alanine, Amino Acid Sequence, Animals, Arginine, Blotting, Northern, COS Cells, Chromatography, Thin Layer, Cloning, Molecular, Cnidaria, Cyclooxygenase 1, Cyclooxygenase 2, DNA, Complementary, HeLa Cells, Histidine, Humans, Isoenzymes, Isoleucine, Membrane Proteins, Microscopy, Fluorescence, Models, Genetic, Molecular Sequence Data, Phylogeny, Plasmids, Polymerase Chain Reaction, Prostaglandin-Endoperoxide Synthases, Prostaglandins, Protein Binding, RNA, Messenger, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Serine, Tyrosine
Added December 10, 2013
0 Communities
1 Members
0 Resources
32 MeSH Terms
Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla.
Boutaud O, Brash AR
(1999) J Biol Chem 274: 33764-70
MeSH Terms: Animals, Base Sequence, Catalase, Catalysis, Chromatography, Affinity, Chromatography, High Pressure Liquid, Cnidaria, DNA Primers, Electrophoresis, Polyacrylamide Gel, Hydrogen-Ion Concentration, Intramolecular Oxidoreductases, Lipoxygenase, Recombinant Fusion Proteins, Salts, Substrate Specificity
Added December 10, 2013
0 Communities
2 Members
0 Resources
15 MeSH Terms
Evidence of a cyclooxygenase-related prostaglandin synthesis in coral. The allene oxide pathway is not involved in prostaglandin biosynthesis.
Varvas K, Järving I, Koljak R, Valmsen K, Brash AR, Samel N
(1999) J Biol Chem 274: 9923-9
MeSH Terms: Alkadienes, Animals, Anti-Inflammatory Agents, Non-Steroidal, Arachidonic Acid, Aspirin, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Cnidaria, Gas Chromatography-Mass Spectrometry, Indomethacin, Leukotrienes, Magnetic Resonance Spectroscopy, Oxides, Prostaglandin-Endoperoxide Synthases, Prostaglandins, ortho-Aminobenzoates
Added December 10, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms
Identification of a naturally occurring peroxidase-lipoxygenase fusion protein.
Koljak R, Boutaud O, Shieh BH, Samel N, Brash AR
(1997) Science 277: 1994-6
MeSH Terms: Amino Acid Sequence, Animals, Arachidonic Acid, Binding Sites, Catalase, Catalysis, Cloning, Molecular, Cnidaria, Hydrogen Peroxide, Intramolecular Oxidoreductases, Isomerases, Lipoxygenase, Molecular Sequence Data, Peroxidase, Peroxidases, Recombinant Proteins, Sequence Homology, Amino Acid
Added December 10, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Purification and molecular cloning of an 8R-lipoxygenase from the coral Plexaura homomalla reveal the related primary structures of R- and S-lipoxygenases.
Brash AR, Boeglin WE, Chang MS, Shieh BH
(1996) J Biol Chem 271: 20949-57
MeSH Terms: Amino Acid Sequence, Animals, Arachidonate Lipoxygenases, Base Sequence, Binding Sites, Cloning, Molecular, Cnidaria, DNA, Complementary, Genes, Molecular Sequence Data, Molecular Weight, Peptide Fragments, Sequence Alignment, Sequence Homology, Amino Acid, Stereoisomerism, Substrate Specificity
Added December 10, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms