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Results: 1 to 10 of 17

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infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease.
Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, Lacy DB, Abud HE, Lyras D
(2020) Proc Natl Acad Sci U S A 117: 8064-8073
MeSH Terms: Animals, Bacterial Proteins, Bacterial Toxins, Cells, Cultured, Clostridioides difficile, Clostridium Infections, Colon, Disease Models, Animal, Female, Frizzled Receptors, Humans, Intestinal Mucosa, Mice, Organoids, Primary Cell Culture, Recombinant Proteins, Stem Cells
Added March 24, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Intestinal bile acids directly modulate the structure and function of TcdB toxin.
Tam J, Icho S, Utama E, Orrell KE, Gómez-Biagi RF, Theriot CM, Kroh HK, Rutherford SA, Lacy DB, Melnyk RA
(2020) Proc Natl Acad Sci U S A 117: 6792-6800
MeSH Terms: Bacterial Toxins, Bile Acids and Salts, Caco-2 Cells, Clostridioides difficile, Clostridium Infections, HCT116 Cells, Humans, Intestines, Receptors, Cell Surface
Added March 24, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
The Immune Protein Calprotectin Impacts Clostridioides difficile Metabolism through Zinc Limitation.
Lopez CA, Beavers WN, Weiss A, Knippel RJ, Zackular JP, Chazin W, Skaar EP
(2019) mBio 10:
MeSH Terms: Clostridioides difficile, Clostridium Infections, Energy Metabolism, Fermentation, Gene Expression Regulation, Bacterial, Leukocyte L1 Antigen Complex, Proline, Zinc
Added March 11, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Colitis while Dysregulating the Inflammatory Response.
Maseda D, Zackular JP, Trindade B, Kirk L, Roxas JL, Rogers LM, Washington MK, Du L, Koyama T, Viswanathan VK, Vedantam G, Schloss PD, Crofford LJ, Skaar EP, Aronoff DM
(2019) mBio 10:
MeSH Terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, CD4-Positive T-Lymphocytes, Clostridium Infections, Gastrointestinal Microbiome, Indomethacin, Intestinal Mucosa, Mice, Neutrophils, Prostaglandins, Survival Analysis
Added April 7, 2019
0 Communities
2 Members
0 Resources
11 MeSH Terms
Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection.
Knippel RJ, Zackular JP, Moore JL, Celis AI, Weiss A, Washington MK, DuBois JL, Caprioli RM, Skaar EP
(2018) PLoS Pathog 14: e1007486
MeSH Terms: Animals, Bacterial Proteins, Clostridioides difficile, Clostridium Infections, Genes, Bacterial, Heme, Male, Mice, Mice, Inbred C57BL, Operon, Virulence
Added April 7, 2019
0 Communities
2 Members
0 Resources
11 MeSH Terms
The role of zinc and nutritional immunity in Clostridium difficile infection.
Zackular JP, Skaar EP
(2018) Gut Microbes 9: 469-476
MeSH Terms: Animals, Anti-Bacterial Agents, Clostridioides difficile, Clostridium Infections, Disease Models, Animal, Gastrointestinal Microbiome, Humans, Immunity, Mice, Zinc
Added March 15, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
The role of toxins in Clostridium difficile infection.
Chandrasekaran R, Lacy DB
(2017) FEMS Microbiol Rev 41: 723-750
MeSH Terms: Bacterial Toxins, Clostridioides difficile, Clostridium Infections, Humans, Immunity, Intestinal Mucosa
Added April 3, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms
Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis.
Chandrasekaran R, Kenworthy AK, Lacy DB
(2016) PLoS Pathog 12: e1006070
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Bacterial Toxins, Blotting, Western, Caco-2 Cells, Clathrin, Clostridioides difficile, Clostridium Infections, Endocytosis, Enterotoxins, Fluorescent Antibody Technique, Gene Knockdown Techniques, HEK293 Cells, Humans, Image Processing, Computer-Assisted, Mice, Microscopy, Confocal, Protein Transport, Reverse Transcriptase Polymerase Chain Reaction, Transfection, Virulence Factors
Added April 26, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.
Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP
(2016) Nat Med 22: 1330-1334
MeSH Terms: Adult, Aged, Aged, 80 and over, Animals, Anti-Bacterial Agents, Bacterial Proteins, Bacterial Toxins, Calgranulin B, Cecum, Child, Clostridioides difficile, Clostridium Infections, Cohort Studies, Colon, Cytokines, Diet, Disease Models, Animal, Disease Susceptibility, Enterotoxins, Female, Gastrointestinal Microbiome, Humans, Male, Mass Spectrometry, Mice, Mice, Knockout, Middle Aged, Polymerase Chain Reaction, Prospective Studies, RNA, Ribosomal, 16S, Trace Elements, Young Adult, Zinc
Added April 8, 2017
1 Communities
4 Members
0 Resources
33 MeSH Terms
Clostridium difficile infection.
Smits WK, Lyras D, Lacy DB, Wilcox MH, Kuijper EJ
(2016) Nat Rev Dis Primers 2: 16020
MeSH Terms: Ampicillin, Anti-Bacterial Agents, Bacterial Toxins, Clindamycin, Clostridioides difficile, Clostridium Infections, Diarrhea, Enterotoxins, Gastrointestinal Microbiome, Humans, Risk Factors, Sugar Alcohol Dehydrogenases
Added April 26, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms