Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner.
Gowrikumar S, Ahmad R, Uppada SB, Washington MK, Shi C, Singh AB, Dhawan P
(2019) Oncogene 38
: 5321-5337MeSH Terms: Animals, Biomarkers, Tumor, Cells, Cultured, Claudin-1, Colitis, Colonic Neoplasms, Gene Expression Regulation, Neoplastic, HT29 Cells, Humans, Inflammatory Bowel Diseases, Intestinal Mucosa, Mice, Mice, Inbred C57BL, Mice, Transgenic, Phosphorylation, Prognosis, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-akt, Receptors, Notch, Signal Transduction, Up-Regulation, beta CateninAdded April 24, 2019
22 MeSH Terms
Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens.
Wu J, Peng D, Zhang Y, Lu Z, Voehler M, Sanders CR, Li J
(2015) Biochem Biophys Res Commun 459
: 87-93MeSH Terms: Amino Acid Motifs, Claudin-1, Claudin-2, Claudin-3, Claudin-5, Claudins, Humans, Nuclear Magnetic Resonance, Biomolecular, Peripheral Nerves, Protein Structure, Secondary, Zonula Occludens-2 ProteinAdded February 5, 2016
11 MeSH Terms
Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ.
Suarez S, McCollum GW, Bretz CA, Yang R, Capozzi ME, Penn JS
(2014) Invest Ophthalmol Vis Sci 55
: 8232-40MeSH Terms: Analysis of Variance, Animals, Capillary Permeability, Cell Membrane, Cells, Cultured, Claudin-1, Claudin-5, Electric Impedance, Endothelial Cells, Extracellular Signal-Regulated MAP Kinases, Humans, Immunohistochemistry, MAP Kinase Signaling System, Mice, Mice, Inbred C57BL, Models, Animal, Peroxisome Proliferator-Activated Receptors, Receptors, Vascular Endothelial Growth Factor, Retina, Retinal Vessels, Sulfones, Thiophenes, Vascular Endothelial Growth Factor AAdded February 19, 2015
23 MeSH Terms
Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis.
Pope JL, Ahmad R, Bhat AA, Washington MK, Singh AB, Dhawan P
(2014) Mol Cancer 13
: 167MeSH Terms: Adenomatous Polyposis Coli, Adenomatous Polyposis Coli Protein, Animals, Cell Transformation, Neoplastic, Claudin-1, Colonic Neoplasms, Epithelial Cells, Gene Expression Regulation, Neoplastic, Interleukin-23 Subunit p19, Intestinal Mucosa, Intestines, Mice, Mucin-2Added December 8, 2014
13 MeSH Terms
Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells.
Sharma A, Bhat AA, Krishnan M, Singh AB, Dhawan P
(2013) Carcinogenesis 34
: 2610-21MeSH Terms: 3' Untranslated Regions, Base Sequence, Blotting, Western, Breast Neoplasms, Cells, Cultured, Chromatin Immunoprecipitation, Claudin-1, Colonic Neoplasms, ELAV Proteins, Epigenesis, Genetic, Female, Fluorescent Antibody Technique, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Immunoenzyme Techniques, Kidney, Molecular Sequence Data, Mutagenesis, Site-Directed, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, TristetraprolinAdded March 7, 2014
24 MeSH Terms
Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.
Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK, Beauchamp RD, Singh AB, Dhawan P
(2014) Gut 63
: 622-34MeSH Terms: Animals, Apoptosis, Cell Differentiation, Cell Proliferation, Claudin-1, Colitis, Colon, Dextran Sulfate, Disease Models, Animal, Homeostasis, Intestinal Mucosa, Mice, Mice, Inbred C57BL, Mice, Transgenic, Real-Time Polymerase Chain Reaction, Receptors, Notch, Signal TransductionAdded January 20, 2014
17 MeSH Terms
Rab25 regulates integrin expression in polarized colonic epithelial cells.
Krishnan M, Lapierre LA, Knowles BC, Goldenring JR
(2013) Mol Biol Cell 24
: 818-31MeSH Terms: Adenovirus E1A Proteins, Caco-2 Cells, Cell Line, Tumor, Cell Movement, Cell Polarity, Claudin-1, Epithelial Cells, Gene Expression Regulation, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Integrin alpha2, Integrin alpha5, Integrin alpha5beta1, Integrin beta1, Integrins, Intestinal Mucosa, Microvilli, Neoplasm Invasiveness, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, RNA Interference, rab GTP-Binding ProteinsAdded October 7, 2013
23 MeSH Terms
Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner.
Singh AB, Sharma A, Dhawan P
(2012) Carcinogenesis 33
: 2538-47MeSH Terms: Anoikis, Cell Line, Tumor, Claudin-1, Colonic Neoplasms, Humans, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-bcl-2, src-Family KinasesAdded March 7, 2014
8 MeSH Terms
Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells.
Bhat AA, Sharma A, Pope J, Krishnan M, Washington MK, Singh AB, Dhawan P
(2012) PLoS One 7
: e37174MeSH Terms: Base Sequence, Binding Sites, CDX2 Transcription Factor, Cell Line, Tumor, Claudin-1, Colorectal Neoplasms, DNA, GATA4 Transcription Factor, Gene Expression Regulation, Homeodomain Proteins, Humans, Molecular Sequence Data, Promoter Regions, Genetic, Transcription, Genetic, Wnt ProteinsAdded June 28, 2013
15 MeSH Terms
Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells.
Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P
(2011) Gastroenterology 141
: 2140-53MeSH Terms: Anoikis, Cadherins, Cell Line, Tumor, Claudin-1, Colonic Neoplasms, Disease Progression, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Immunoblotting, Membrane Proteins, Microarray Analysis, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Transcription Factors, Up-Regulation, Zinc Finger E-box-Binding Homeobox 1Added June 14, 2013
18 MeSH Terms