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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 31

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TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR Metastatic Triple-Negative Breast Cancer.
Lehmann BD, Abramson VG, Sanders ME, Mayer EL, Haddad TC, Nanda R, Van Poznak C, Storniolo AM, Nangia JR, Gonzalez-Ericsson PI, Sanchez V, Johnson KN, Abramson RG, Chen SC, Shyr Y, Arteaga CL, Wolff AC, Pietenpol JA, Translational Breast Cancer Research Consortium
(2020) Clin Cancer Res 26: 2111-2123
MeSH Terms: Androgen Receptor Antagonists, Antineoplastic Combined Chemotherapy Protocols, Class I Phosphatidylinositol 3-Kinases, Female, Humans, Imidazoles, Middle Aged, Neoplasm Metastasis, Oxazepines, Phenylthiohydantoin, Protein Kinase Inhibitors, Receptors, Androgen, Survival Rate, Triple Negative Breast Neoplasms
Added March 30, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas.
Huo D, Hu H, Rhie SK, Gamazon ER, Cherniack AD, Liu J, Yoshimatsu TF, Pitt JJ, Hoadley KA, Troester M, Ru Y, Lichtenberg T, Sturtz LA, Shelley CS, Benz CC, Mills GB, Laird PW, Shriver CD, Perou CM, Olopade OI
(2017) JAMA Oncol 3: 1654-1662
MeSH Terms: African Americans, Aged, Breast Neoplasms, Breast Neoplasms, Male, Class I Phosphatidylinositol 3-Kinases, Databases, Factual, European Continental Ancestry Group, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Mutation, Precision Medicine, Receptor, ErbB-2, Survival Analysis, Tumor Suppressor Protein p53, United States
Added May 10, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms
The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines.
Riquelme I, Tapia O, Espinoza JA, Leal P, Buchegger K, Sandoval A, Bizama C, Araya JC, Peek RM, Roa JC
(2016) Pathol Oncol Res 22: 797-805
MeSH Terms: Adaptor Proteins, Signal Transducing, Cell Cycle Proteins, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Gene Expression, Humans, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphoproteins, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 70-kDa, Signal Transduction, Stomach Neoplasms, TOR Serine-Threonine Kinases
Added April 6, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway.
Riquelme I, Tapia O, Leal P, Sandoval A, Varga MG, Letelier P, Buchegger K, Bizama C, Espinoza JA, Peek RM, Araya JC, Roa JC
(2016) Cell Oncol (Dordr) 39: 23-33
MeSH Terms: Base Sequence, Cell Death, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Down-Regulation, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Humans, MicroRNAs, Models, Biological, Molecular Sequence Data, Neoplasm Invasiveness, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, Stomach Neoplasms, TOR Serine-Threonine Kinases, Transfection, Tuberous Sclerosis Complex 1 Protein, Tumor Stem Cell Assay, Tumor Suppressor Proteins
Added February 5, 2016
0 Communities
1 Members
0 Resources
24 MeSH Terms
Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer.
Young CD, Zimmerman LJ, Hoshino D, Formisano L, Hanker AB, Gatza ML, Morrison MM, Moore PD, Whitwell CA, Dave B, Stricker T, Bhola NE, Silva GO, Patel P, Brantley-Sieders DM, Levin M, Horiates M, Palma NA, Wang K, Stephens PJ, Perou CM, Weaver AM, O'Shaughnessy JA, Chang JC, Park BH, Liebler DC, Cook RS, Arteaga CL
(2015) Mol Cell Proteomics 14: 1959-76
MeSH Terms: Amphiregulin, Animals, Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Chromatography, Liquid, Class I Phosphatidylinositol 3-Kinases, Disease-Free Survival, Down-Regulation, Epidermal Growth Factor, ErbB Receptors, Extracellular Matrix, Extracellular Signal-Regulated MAP Kinases, Female, Humans, Mice, Nude, Mutation, Neoplasm Proteins, Paracrine Communication, Phosphatidylinositol 3-Kinases, Protein Binding, Protein Kinase Inhibitors, Proteomics, Signal Transduction, Tandem Mass Spectrometry, Up-Regulation
Added February 15, 2016
1 Communities
3 Members
0 Resources
26 MeSH Terms
Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies.
Wirtz ED, Hoshino D, Maldonado AT, Tyson DR, Weaver AM
(2015) JAMA Otolaryngol Head Neck Surg 141: 543-9
MeSH Terms: Benzoquinones, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Head and Neck Neoplasms, Humans, Imidazoles, Indazoles, Inhibitory Concentration 50, Lactams, Macrocyclic, Molecular Targeted Therapy, Mutation, Phosphatidylinositol 3-Kinases, Protein-Serine-Threonine Kinases, Pyridones, Pyrimidinones, Quinolines, Squamous Cell Carcinoma of Head and Neck, Sulfonamides, TOR Serine-Threonine Kinases, Tumor Cells, Cultured
Added February 15, 2016
1 Communities
1 Members
0 Resources
22 MeSH Terms
PIK3CA mutations in Peruvian patients with HER2-amplified and triple negative non-metastatic breast cancers.
Castaneda CA, Lopez-Ilasaca M, Pinto JA, Chirinos-Arias M, Doimi F, Neciosup SP, Rojas KI, Vidaurre T, Balko JM, Arteaga CL, Gomez HL
(2014) Hematol Oncol Stem Cell Ther 7: 142-8
MeSH Terms: Biomarkers, Tumor, Breast Neoplasms, Class I Phosphatidylinositol 3-Kinases, Cohort Studies, Exons, Female, Gene Amplification, Humans, Middle Aged, Mutation, Neoadjuvant Therapy, Peru, Phosphatidylinositol 3-Kinases, Receptor, ErbB-2, Triple Negative Breast Neoplasms
Added April 6, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC
(2014) Gastroenterology 147: 1405-16.e7
MeSH Terms: Acinar Cells, Adenocarcinoma, Animals, Carcinogenesis, Carcinoma, Pancreatic Ductal, Cell Transformation, Neoplastic, Class I Phosphatidylinositol 3-Kinases, Cytoskeleton, Female, Humans, Male, Mice, Mutant Strains, Neuropeptides, Phosphatidylinositol 3-Kinases, Primary Cell Culture, Proto-Oncogene Proteins p21(ras), Signal Transduction, Transcriptome, rac1 GTP-Binding Protein
Added March 13, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors.
Lehmann BD, Bauer JA, Schafer JM, Pendleton CS, Tang L, Johnson KC, Chen X, Balko JM, Gómez H, Arteaga CL, Mills GB, Sanders ME, Pietenpol JA
(2014) Breast Cancer Res 16: 406
MeSH Terms: Androgen Receptor Antagonists, Animals, Antineoplastic Agents, Cell Line, Tumor, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Cluster Analysis, Dihydrotestosterone, Disease Models, Animal, Drug Resistance, Neoplasm, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Mutation, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors, Receptors, Androgen, Signal Transduction, TOR Serine-Threonine Kinases, Triple Negative Breast Neoplasms, Xenograft Model Antitumor Assays
Added January 20, 2015
1 Communities
2 Members
0 Resources
23 MeSH Terms
Characterization of breast cancers with PI3K mutations in an academic practice setting using SNaPshot profiling.
Abramson VG, Cooper Lloyd M, Ballinger T, Sanders ME, Du L, Lai D, Su Z, Mayer I, Levy M, LaFrance DR, Vnencak-Jones CL, Shyr Y, Dahlman KB, Pao W, Arteaga CL
(2014) Breast Cancer Res Treat 145: 389-99
MeSH Terms: Academic Medical Centers, Adult, Aged, Breast Neoplasms, Class I Phosphatidylinositol 3-Kinases, Clinical Trials as Topic, DNA Mutational Analysis, Female, Humans, Middle Aged, Mutation, Neoplasm Recurrence, Local, Patient Participation, Phosphatidylinositol 3-Kinases, Receptor, ErbB-2, Time Factors
Added May 27, 2014
0 Communities
3 Members
0 Resources
16 MeSH Terms