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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 26

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Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells.
Lis C, Rubner S, Roatsch M, Berg A, Gilcrest T, Fu D, Nguyen E, Schmidt AM, Krautscheid H, Meiler J, Berg T
(2017) Sci Rep 7: 17390
MeSH Terms: Antineoplastic Agents, Apoptosis, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Chromones, Humans, Lung Neoplasms, Molecular Docking Simulation, Phosphorylation, Protein Processing, Post-Translational, STAT1 Transcription Factor, STAT3 Transcription Factor, STAT5 Transcription Factor, Structure-Activity Relationship, Tumor Suppressor Proteins, src Homology Domains
Added March 17, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line.
Bryan MR, Uhouse MA, Nordham KD, Joshi P, Rose DIR, O'Brien MT, Aschner M, Bowman AB
(2018) Neurotoxicology 64: 185-194
MeSH Terms: Animals, Cell Line, Chromones, Corpus Striatum, HEK293 Cells, Homeostasis, Humans, Induced Pluripotent Stem Cells, Inhibitory Concentration 50, Manganese, Mice, Morpholines, Neural Stem Cells, Phosphatidylinositol 3-Kinase, Signal Transduction, Tumor Suppressor Protein p53
Added April 11, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Inflammatory cytokine TSLP stimulates platelet secretion and potentiates platelet aggregation via a TSLPR-dependent PI3K/Akt signaling pathway.
Dong J, Dong J, Lin J, Wang B, He S, Wu C, Kushwaha KK, Mohabeer N, Su Y, Fang H, Huang K, Li D
(2015) Cell Physiol Biochem 35: 160-74
MeSH Terms: Androstadienes, Animals, Blood Platelets, Carotid Artery Thrombosis, Chlorides, Chromones, Cytokines, Disease Models, Animal, Ferric Compounds, Humans, Immunoglobulins, Mice, Mice, Inbred C57BL, Mice, Knockout, Morpholines, P-Selectin, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Platelet Activation, Platelet Aggregation, Platelet Glycoprotein GPIIb-IIIa Complex, Proto-Oncogene Proteins c-akt, Receptors, Cytokine, Signal Transduction, Wortmannin
Added January 20, 2015
0 Communities
1 Members
0 Resources
26 MeSH Terms
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.
Zhang B, Zhang B, Chen X, Bae S, Singh K, Washington MK, Datta PK
(2014) Br J Cancer 110: 946-57
MeSH Terms: Animals, Antimetabolites, Antineoplastic, Apoptosis Regulatory Proteins, Cell Cycle Proteins, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Chromones, Colorectal Neoplasms, Drug Resistance, Neoplasm, Enzyme Activation, Enzyme Inhibitors, Fluorouracil, Humans, Inhibitor of Apoptosis Proteins, Mice, Mice, Inbred BALB C, Morpholines, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Transplantation, Neovascularization, Pathologic, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Proteins, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-bcl-2, Repressor Proteins, Retinoblastoma Protein, Smad4 Protein, Survivin, Up-Regulation, Vascular Endothelial Growth Factor A, Wound Healing, Xenograft Model Antitumor Assays
Added April 12, 2016
0 Communities
1 Members
0 Resources
37 MeSH Terms
Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells.
Vangamudi B, Zhu S, Soutto M, Belkhiri A, El-Rifai W
(2011) Mol Cancer 10: 32
MeSH Terms: Binding Sites, Blotting, Western, Cell Line, Tumor, Cell Nucleus, Cell Proliferation, Chromones, Dopamine and cAMP-Regulated Phosphoprotein 32, Enzyme Inhibitors, Gastrointestinal Neoplasms, Gene Expression Regulation, Neoplastic, Glycogen Synthase Kinase 3, Glycogen Synthase Kinase 3 beta, Humans, Luciferases, Microscopy, Fluorescence, Morpholines, Mutation, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Protein Isoforms, Proto-Oncogene Proteins c-akt, RNA Interference, Signal Transduction, TCF Transcription Factors, Upper Gastrointestinal Tract, beta Catenin
Added July 26, 2012
1 Communities
1 Members
0 Resources
27 MeSH Terms
Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.
Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE
(2011) Arterioscler Thromb Vasc Biol 31: 435-42
MeSH Terms: 1-Butanol, 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid, Arachidonate 12-Lipoxygenase, Arachidonic Acid, Blood Platelets, Calcium, Chromones, Cyclooxygenase 1, Cytosol, Eicosanoids, Enzyme Inhibitors, Group IV Phospholipases A2, Humans, In Vitro Techniques, Morpholines, Propranolol, Protein Kinase C, Receptors, Proteinase-Activated, Signal Transduction, Thromboxane A2, p38 Mitogen-Activated Protein Kinases
Added March 20, 2014
1 Communities
2 Members
0 Resources
21 MeSH Terms
t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer.
Vangamudi B, Peng DF, Cai Q, El-Rifai W, Zheng W, Belkhiri A
(2010) Mol Cancer 9: 240
MeSH Terms: Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Cell Survival, Chromones, Cyclin D1, Dopamine and cAMP-Regulated Phosphoprotein 32, Female, Humans, Immunoblotting, Immunohistochemistry, Morpholines, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Polymerase Chain Reaction, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-myc, RNA, Small Interfering
Added March 5, 2014
0 Communities
4 Members
0 Resources
19 MeSH Terms
Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.
Vilar E, Mukherjee B, Kuick R, Raskin L, Misek DE, Taylor JM, Giordano TJ, Hanash SM, Fearon ER, Rennert G, Gruber SB
(2009) Clin Cancer Res 15: 2829-39
MeSH Terms: Algorithms, Antineoplastic Agents, Benzoquinones, Cell Cycle, Cell Line, Tumor, Chromones, Colorectal Neoplasms, Computational Biology, DNA Mismatch Repair, Drug Evaluation, Preclinical, Enzyme Inhibitors, Gene Expression Profiling, Humans, Hydroxamic Acids, Immunosuppressive Agents, Lactams, Macrocyclic, Microsatellite Instability, Morpholines, Phosphoinositide-3 Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Sirolimus
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung.
Qian J, Zou Y, Rahman JS, Lu B, Massion PP
(2009) Mol Cancer Ther 8: 101-9
MeSH Terms: Adenocarcinoma, Apoptosis, Apoptosis Regulatory Proteins, Bcl-2-Like Protein 11, Cell Line, Tumor, Chromones, Humans, Lung Neoplasms, Membrane Proteins, Morpholines, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Signal Transduction, Substrate Specificity, bcl-X Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
PI3K signaling supports amphetamine-induced dopamine efflux.
Lute BJ, Khoshbouei H, Saunders C, Sen N, Lin RZ, Javitch JA, Galli A
(2008) Biochem Biophys Res Commun 372: 656-61
MeSH Terms: Amphetamine, Animals, Central Nervous System Stimulants, Chromones, Dopamine, Dopamine Plasma Membrane Transport Proteins, Mice, Mice, Transgenic, Morpholines, Neurons, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors, Signal Transduction
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms