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Functional defects in TcdB toxin uptake identify CSPG4 receptor-binding determinants.
Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA
(2017) J Biol Chem 292: 17290-17301
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Bacterial Proteins, Bacterial Toxins, Broadly Neutralizing Antibodies, CHO Cells, Caco-2 Cells, Chlorocebus aethiops, Chondroitin Sulfate Proteoglycans, Clostridioides difficile, Cricetinae, Cricetulus, Glucosyltransferases, HEK293 Cells, Humans, Membrane Proteins, Protein Binding, Protein Domains
Added April 3, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.
Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, Kahali B, Carr JJ, Harris TB, Jhun MA, Kardia SL, Langefeld CD, Mosley TH, Norris JM, Smith AV, Taylor HA, Wagenknecht LE, Liu J, Borecki IB, Peyser PA, Speliotes EK
(2013) Hepatology 58: 966-75
MeSH Terms: Adaptor Proteins, Signal Transducing, Adult, Aged, Blacks, Chondroitin Sulfate Proteoglycans, Cohort Studies, Fatty Liver, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Hispanic or Latino, Humans, Lectins, C-Type, Lipase, Lysophospholipase, Male, Membrane Proteins, Middle Aged, Nerve Tissue Proteins, Neurocan, Non-alcoholic Fatty Liver Disease, Phosphoprotein Phosphatases, Whites
Added February 28, 2014
1 Communities
1 Members
0 Resources
24 MeSH Terms
Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation.
Eames BF, Yan YL, Swartz ME, Levic DS, Knapik EW, Postlethwait JH, Kimmel CB
(2011) PLoS Genet 7: e1002246
MeSH Terms: Animals, Cartilage, Cells, Cultured, Chondrocytes, Chondroitin Sulfate Proteoglycans, Collagen, Hedgehog Proteins, Mutation, Osteogenesis, Pentosyltransferases, Phosphotransferases (Alcohol Group Acceptor), Zebrafish, Zebrafish Proteins
Added February 19, 2015
1 Communities
1 Members
0 Resources
13 MeSH Terms
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS, NASH CRN, GIANT Consortium, MAGIC Investigators, Voight BF, Carr JJ, Feitosa MF, Harris TB, Fox CS, Smith AV, Kao WH, Hirschhorn JN, Borecki IB, GOLD Consortium
(2011) PLoS Genet 7: e1001324
MeSH Terms: Adaptor Proteins, Signal Transducing, Adult, Aged, Aged, 80 and over, Blood Glucose, Case-Control Studies, Chondroitin Sulfate Proteoglycans, Cohort Studies, Fatty Liver, Genome-Wide Association Study, Humans, Insulin, Lectins, C-Type, Lipase, Male, Membrane Proteins, Middle Aged, Mutation, Missense, Nerve Tissue Proteins, Neurocan, Non-alcoholic Fatty Liver Disease, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Tomography, X-Ray Computed
Added February 15, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
Ammonium chloride interferes with a distinct step in the biosynthesis and cell surface expression of human melanoma-type chondroitin sulfate proteoglycan.
Harper JR, Quaranta V, Reisfeld RA
(1986) J Biol Chem 261: 3600-6
MeSH Terms: Aggrecans, Ammonium Chloride, Chondroitin Sulfate Proteoglycans, Extracellular Matrix Proteins, Glucosamine, Glycoproteins, Glycosaminoglycans, Humans, In Vitro Techniques, Lectins, C-Type, Melanoma, Monensin, Proteoglycans, Tritium
Added March 27, 2014
1 Communities
1 Members
0 Resources
14 MeSH Terms
The human invariant chain is the core protein of the human class II-associated proteoglycan.
Giacoletto KS, Sant AJ, Bono C, Gorka J, O'Sullivan DM, Quaranta V, Schwartz BD
(1986) J Exp Med 164: 1422-39
MeSH Terms: Antigens, Differentiation, B-Lymphocyte, Chondroitin Sulfate Proteoglycans, Chondroitinases and Chondroitin Lyases, Chromobox Protein Homolog 5, Electrophoresis, Polyacrylamide Gel, Histocompatibility Antigens Class II, Humans, Methionine, Molecular Weight, Proteoglycans, Solubility
Added March 27, 2014
1 Communities
1 Members
0 Resources
11 MeSH Terms
The HLA-class II-associated chondroitin sulfate proteoglycan expressed by class II positive T and monocyte-like cell lines is larger than that expressed by EBV-transformed B-lymphoblastoid cell lines.
Bono C, Pereira MB, O'Sullivan DM, Quaranta V, Schwartz BD
(1987) Hum Immunol 18: 315-30
MeSH Terms: B-Lymphocytes, Cell Line, Cell Transformation, Viral, Chondroitin Sulfate Proteoglycans, HLA-D Antigens, Herpesvirus 4, Human, Humans, Interferon-gamma, Lymphocyte Activation, Lymphocytes, Molecular Weight, Monocytes, Proteoglycans, T-Lymphocytes
Added March 27, 2014
1 Communities
1 Members
0 Resources
14 MeSH Terms