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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 22

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Discovery and Optimization of Potent and CNS Penetrant M-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold.
Bender AM, Cho HP, Nance KD, Lingenfelter KS, Luscombe VB, Gentry PR, Voigtritter K, Berizzi AE, Sexton PM, Langmead CJ, Christopoulos A, Locuson CW, Bridges TM, Chang S, O'Neill JC, Zhan X, Niswender CM, Jones CK, Conn PJ, Lindsley CW
(2018) ACS Chem Neurosci 9: 1572-1581
MeSH Terms: Allosteric Regulation, Amides, Animals, Brain, Cholinergic Agents, Drug Discovery, Humans, Male, Microsomes, Liver, Molecular Structure, Piperidines, Rats, Sprague-Dawley, Receptors, Muscarinic, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
M-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition.
Moran SP, Dickerson JW, Cho HP, Xiang Z, Maksymetz J, Remke DH, Lv X, Doyle CA, Rajan DH, Niswender CM, Engers DW, Lindsley CW, Rook JM, Conn PJ
(2018) Neuropsychopharmacology 43: 1763-1771
MeSH Terms: Allosteric Regulation, Animals, CHO Cells, Cholinergic Agents, Cricetulus, Excitatory Postsynaptic Potentials, Male, Mice, Inbred C57BL, Nootropic Agents, Prefrontal Cortex, Pyramidal Cells, Rats, Rats, Sprague-Dawley, Receptor, Muscarinic M1, Recognition, Psychology, Tissue Culture Techniques
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M Muscarinic Receptor.
Moehle MS, Pancani T, Byun N, Yohn SE, Wilson GH, Dickerson JW, Remke DH, Xiang Z, Niswender CM, Wess J, Jones CK, Lindsley CW, Rook JM, Conn PJ
(2017) Neuron 96: 1358-1372.e4
MeSH Terms: Acetylcholine, Animals, Basal Ganglia, Channelrhodopsins, Choline O-Acetyltransferase, Cholinergic Agents, Cholinergic Neurons, Dopamine, Inhibitory Postsynaptic Potentials, Locomotion, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurotransmitter Agents, Oxygen, Pars Reticulata, Pedunculopontine Tegmental Nucleus, Receptor, Muscarinic M4, Receptors, Dopamine D1, Signal Transduction
Added March 14, 2018
0 Communities
4 Members
0 Resources
20 MeSH Terms
Role of mGlu Receptors and Inhibitory Neurotransmission in M Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia.
Ghoshal A, Moran SP, Dickerson JW, Joffe ME, Grueter BA, Xiang Z, Lindsley CW, Rook JM, Conn PJ
(2017) ACS Chem Neurosci 8: 2254-2265
MeSH Terms: Animals, Antipsychotic Agents, Cholinergic Agents, Cognition, Mice, Inbred C57BL, Neuronal Plasticity, Phencyclidine, Prefrontal Cortex, Receptor, Metabotropic Glutamate 5, Receptors, N-Methyl-D-Aspartate, Schizophrenia, Synaptic Transmission
Added March 21, 2018
0 Communities
1 Members
0 Resources
12 MeSH Terms
M muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons.
Lv X, Dickerson JW, Rook JM, Lindsley CW, Conn PJ, Xiang Z
(2017) Neuropharmacology 118: 209-222
MeSH Terms: Acetylcholine, Action Potentials, Animals, Channelrhodopsins, Choline O-Acetyltransferase, Cholinergic Agents, Corpus Striatum, Cues, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Female, Gene Expression Regulation, Learning, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Neurons, Photic Stimulation, Receptor, Muscarinic M1
Added April 6, 2017
0 Communities
2 Members
0 Resources
21 MeSH Terms
Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease.
Kamkwalala AR, Newhouse PA
(2017) Curr Alzheimer Res 14: 377-392
MeSH Terms: Alzheimer Disease, Animals, Cholinergic Agents, Humans, Neuroprotective Agents, Nootropic Agents
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M PAM VU6004256.
Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK
(2016) ACS Chem Neurosci 7: 1706-1716
MeSH Terms: Action Potentials, Animals, Cholinergic Agents, Cognition Disorders, Conditioning, Psychological, Disease Models, Animal, Drug Evaluation, Preclinical, Fear, Gene Knockdown Techniques, Heterocyclic Compounds, 4 or More Rings, Long-Term Synaptic Depression, Male, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Nerve Tissue Proteins, Nootropic Agents, Prefrontal Cortex, Pyramidal Cells, Receptors, N-Methyl-D-Aspartate, Recognition, Psychology, Tissue Culture Techniques
Added April 6, 2017
0 Communities
3 Members
0 Resources
23 MeSH Terms
Estrogen-cholinergic interactions: Implications for cognitive aging.
Newhouse P, Dumas J
(2015) Horm Behav 74: 173-85
MeSH Terms: Acetylcholine, Aged, Attention, Brain, Cholinergic Agents, Cholinergic Neurons, Cognition, Cognitive Aging, Estradiol, Estrogen Replacement Therapy, Female, Humans, Learning, Memory, Short-Term, Tamoxifen
Added February 22, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice.
Gould RW, Dencker D, Grannan M, Bubser M, Zhan X, Wess J, Xiang Z, Locuson C, Lindsley CW, Conn PJ, Jones CK
(2015) ACS Chem Neurosci 6: 1683-95
MeSH Terms: Analysis of Variance, Animals, Cholinergic Agents, Cognition Disorders, Conditioning, Operant, Discrimination, Psychological, Dose-Response Relationship, Drug, Gene Expression Regulation, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pattern Recognition, Visual, Photic Stimulation, Quinolones, RNA, Messenger, Receptor, Muscarinic M1, Reinforcement Schedule, Reinforcement, Psychology, Touch
Added February 18, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.
Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, Dunlop J, Wood MW, Brandon NJ, Wood MR, Lindsley CW, Conn PJ, Jones CK
(2014) ACS Chem Neurosci 5: 920-42
MeSH Terms: Amphetamines, Animals, Association Learning, Brain, Cell Line, Central Nervous System Stimulants, Cholinergic Agents, Cricetulus, Dizocilpine Maleate, Dogs, Dose-Response Relationship, Drug, Excitatory Amino Acid Antagonists, Humans, Macaca fascicularis, Male, Mice, Inbred C57BL, Mice, Knockout, Motor Activity, Psychotropic Drugs, Pyridazines, Rats, Rats, Sprague-Dawley, Receptor, Muscarinic M4, Thiophenes
Added February 19, 2015
0 Communities
3 Members
0 Resources
24 MeSH Terms