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Results: 1 to 9 of 9

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Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques.
Broeckel R, Fox JM, Haese N, Kreklywich CN, Sukulpovi-Petty S, Legasse A, Smith PP, Denton M, Corvey C, Krishnan S, Colgin LMA, Ducore RM, Lewis AD, Axthelm MK, Mandron M, Cortez P, Rothblatt J, Rao E, Focken I, Carter K, Sapparapau G, Crowe JE, Diamond MS, Streblow DN
(2017) PLoS Negl Trop Dis 11: e0005637
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, B-Lymphocytes, Chikungunya Fever, Chikungunya virus, Disease Models, Animal, Drug Evaluation, Preclinical, Immunologic Factors, Macaca mulatta, T-Lymphocytes, Treatment Outcome
Added March 14, 2018
0 Communities
1 Members
0 Resources
12 MeSH Terms
The Molecular Basis for the Lack of Inflammatory Responses in Mouse Embryonic Stem Cells and Their Differentiated Cells.
D'Angelo W, Gurung C, Acharya D, Chen B, Ortolano N, Gama V, Bai F, Guo YL
(2017) J Immunol 198: 2147-2155
MeSH Terms: Animals, Cell Differentiation, Chikungunya Fever, Chikungunya virus, Embryonic Stem Cells, Immunity, Inflammation, Interferons, Lipopolysaccharides, Mice, Mice, Inbred DBA, NF-kappa B, RAW 264.7 Cells, Tumor Necrosis Factor-alpha, Virus Diseases
Added July 10, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence.
Hawman DW, Fox JM, Ashbrook AW, May NA, Schroeder KMS, Torres RM, Crowe JE, Dermody TS, Diamond MS, Morrison TE
(2016) Cell Rep 16: 1326-1338
MeSH Terms: Amino Acids, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, B-Lymphocytes, Chikungunya Fever, Chikungunya virus, Glycoproteins, Humans, Mice, Mice, Inbred C57BL, Viral Envelope Proteins
Added April 13, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.
Fox JM, Long F, Edeling MA, Lin H, van Duijl-Richter MKS, Fong RH, Kahle KM, Smit JM, Jin J, Simmons G, Doranz BJ, Crowe JE, Fremont DH, Rossmann MG, Diamond MS
(2015) Cell 163: 1095-1107
MeSH Terms: Alphavirus, Alphavirus Infections, Amino Acid Sequence, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Chikungunya virus, Cryoelectron Microscopy, Epitopes, Glycoproteins, Humans, Immunoglobulin Fab Fragments, Mice, Models, Molecular, Molecular Sequence Data, Protein Structure, Tertiary, Sequence Alignment, Viral Envelope Proteins, Viral Vaccines, Virus Internalization
Added January 26, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
Long F, Fong RH, Austin SK, Chen Z, Klose T, Fokine A, Liu Y, Porta J, Sapparapu G, Akahata W, Doranz BJ, Crowe JE, Diamond MS, Rossmann MG
(2015) Proc Natl Acad Sci U S A 112: 13898-903
MeSH Terms: Antibodies, Monoclonal, Antibodies, Neutralizing, Chikungunya Fever, Chikungunya virus, Cryoelectron Microscopy, Humans, Protein Conformation
Added January 26, 2016
0 Communities
1 Members
0 Resources
7 MeSH Terms
Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.
Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Khomadiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, Brien JD, Austin SK, Diamond MS, Dermody TS, Crowe JE
(2015) Cell Host Microbe 18: 86-95
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Chemoprevention, Chikungunya Fever, Chikungunya virus, Disease Models, Animal, Humans, Immunization, Passive, Inhibitory Concentration 50, Mice, Protein Binding, Survival Analysis, Treatment Outcome, Viral Envelope Proteins, Virus Internalization
Added January 26, 2016
0 Communities
2 Members
0 Resources
17 MeSH Terms
Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.
Mainou BA, Ashbrook AW, Smith EC, Dorset DC, Denison MR, Dermody TS
(2015) J Virol 89: 8701-12
MeSH Terms: Animals, Antiviral Agents, Biological Transport, Cell Line, Cell Survival, Chikungunya virus, Chlorocebus aethiops, Cholera Toxin, Cricetinae, Cytoskeleton, Endosomes, HeLa Cells, Humans, Interferon-gamma, L Cells, Methiothepin, Mice, Murine hepatitis virus, Reoviridae, Reoviridae Infections, Serotonin Antagonists, Transferrin, Tryptamines, Vero Cells, Virus Assembly, Virus Attachment, Virus Internalization
Added February 4, 2016
0 Communities
1 Members
0 Resources
27 MeSH Terms
Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice.
Ashbrook AW, Burrack KS, Silva LA, Montgomery SA, Heise MT, Morrison TE, Dermody TS
(2014) J Virol 88: 12180-92
MeSH Terms: Amino Acid Substitution, Animals, Arthritis, CHO Cells, Chikungunya virus, Cricetulus, Disease Models, Animal, Mice, Inbred C57BL, Mutant Proteins, Viral Envelope Proteins, Viral Tropism, Virulence Factors, Virus Replication
Added January 21, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization.
Silva LA, Khomandiak S, Ashbrook AW, Weller R, Heise MT, Morrison TE, Dermody TS
(2014) J Virol 88: 2385-97
MeSH Terms: Alphavirus Infections, Amino Acid Substitution, Animals, CHO Cells, Chikungunya Fever, Chikungunya virus, Chlorocebus aethiops, Cricetinae, Cricetulus, Endosomes, Genotype, Glycosaminoglycans, Heparitin Sulfate, Humans, Hydrogen Bonding, Kinetics, Models, Molecular, Mutation, Polymorphism, Single Nucleotide, Protein Multimerization, Static Electricity, Vero Cells, Viral Envelope Proteins, Virus Attachment, Virus Internalization, Virus Replication
Added May 20, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms