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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 14

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Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation.
Furniss KL, Tsai HJ, Byl JA, Lane AB, Vas AC, Hsu WS, Osheroff N, Clarke DJ
(2013) PLoS Genet 9: e1003832
MeSH Terms: Cell Cycle, Cell Cycle Checkpoints, Cell Cycle Proteins, Checkpoint Kinase 2, Chromosome Segregation, DNA, DNA Topoisomerases, Type II, Humans, Kinetochores, Mad2 Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Added March 7, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.
Liu Y, Hawkins OE, Su Y, Vilgelm AE, Sobolik T, Thu YM, Kantrow S, Splittgerber RC, Short S, Amiri KI, Ecsedy JA, Sosman JA, Kelley MC, Richmond A
(2013) EMBO Mol Med 5: 149-66
MeSH Terms: Animals, Antineoplastic Agents, Ataxia Telangiectasia Mutated Proteins, Aurora Kinases, Azepines, Benzazepines, Cell Cycle Proteins, Cell Line, Tumor, Cell Proliferation, Cellular Senescence, Checkpoint Kinase 2, DNA Damage, DNA-Binding Proteins, Humans, Melanoma, Experimental, Mice, Mice, Nude, NF-kappa B, Polyploidy, Protein Kinase Inhibitors, Protein-Serine-Threonine Kinases, Pyrimidines, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Xenograft Model Antitumor Assays
Added June 14, 2013
2 Communities
7 Members
0 Resources
25 MeSH Terms
Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.
Zhang B, Beeghly-Fadiel A, Long J, Zheng W
(2011) Lancet Oncol 12: 477-88
MeSH Terms: Antigens, CD, Aromatase, Ataxia Telangiectasia Mutated Proteins, Breast Neoplasms, CTLA-4 Antigen, Caspase 8, Cell Cycle Proteins, Checkpoint Kinase 2, DNA-Binding Proteins, Evidence-Based Medicine, Female, Genetic Predisposition to Disease, Humans, Mutation, Nuclear Proteins, Protein-Serine-Threonine Kinases, Risk Assessment, Risk Factors, Telomerase, Tumor Suppressor Protein p53, Tumor Suppressor Proteins
Added December 10, 2013
0 Communities
3 Members
0 Resources
21 MeSH Terms
no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila.
Merkle JA, Rickmyre JL, Garg A, Loggins EB, Jodoin JN, Lee E, Wu LP, Lee LA
(2009) Development 136: 449-59
MeSH Terms: Amino Acid Sequence, Animals, Checkpoint Kinase 2, DNA Damage, Drosophila, Drosophila Proteins, Embryo, Nonmammalian, Female, HeLa Cells, Humans, Mitosis, Molecular Sequence Data, Mutation, Protein Binding, Protein-Serine-Threonine Kinases, Spindle Apparatus, Two-Hybrid System Techniques, Ubiquitin-Conjugating Enzymes, Ubiquitin-Protein Ligases
Added March 5, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H
(2008) Mol Cell Biol 28: 5874-85
MeSH Terms: Cell Line, Checkpoint Kinase 2, Cullin Proteins, DNA Damage, DNA Repair, Humans, Phosphorylation, Protein-Serine-Threonine Kinases, Radiation, Ionizing, Serine, Signal Transduction, Ubiquitin-Protein Ligases, Ubiquitination
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry.
King JB, Gross J, Lovly CM, Piwnica-Worms H, Townsend RR
(2007) Rapid Commun Mass Spectrom 21: 3443-51
MeSH Terms: Amino Acid Sequence, Checkpoint Kinase 2, Chromatography, Liquid, Cyclotrons, Glutamine, Humans, Molecular Sequence Data, Mutagenesis, Site-Directed, Nanotechnology, Phosphorylation, Protein-Serine-Threonine Kinases, Serine, Spectrometry, Mass, Electrospray Ionization, Spectroscopy, Fourier Transform Infrared, Threonine
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.
Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA
(2007) J Cell Sci 120: 3565-77
MeSH Terms: Animals, Cell Cycle, Cell Cycle Proteins, Checkpoint Kinase 1, Checkpoint Kinase 2, Chromatin, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Genes, Insect, Genomic Instability, Mitosis, Mushroom Bodies, Mutation, Protein Kinases, Protein-Serine-Threonine Kinases
Added March 5, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks.
Herzberg K, Bashkirov VI, Rolfsmeier M, Haghnazari E, McDonald WH, Anderson S, Bashkirova EV, Yates JR, Heyer WD
(2006) Mol Cell Biol 26: 8396-409
MeSH Terms: Adenosine Triphosphatases, Amino Acid Sequence, Cell Cycle Proteins, Checkpoint Kinase 2, DNA Damage, DNA Repair, DNA Repair Enzymes, DNA Replication, DNA, Fungal, DNA-Binding Proteins, Gene Expression Regulation, Fungal, Genome, Mass Spectrometry, Models, Genetic, Molecular Sequence Data, Phosphorylation, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-raf, Rad52 DNA Repair and Recombination Protein, Recombination, Genetic, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Serine
Added March 20, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
de Bruin RA, Kalashnikova TI, Chahwan C, McDonald WH, Wohlschlegel J, Yates J, Russell P, Wittenberg C
(2006) Mol Cell 23: 483-96
MeSH Terms: Amino Acid Sequence, Cell Cycle Proteins, Checkpoint Kinase 2, Feedback, Physiological, G1 Phase, Gene Expression Regulation, Fungal, Genes, Fungal, Hydroxyurea, Intracellular Signaling Peptides and Proteins, Models, Genetic, Molecular Sequence Data, Mutation, Promoter Regions, Genetic, Protein Binding, Protein-Serine-Threonine Kinases, RNA, Messenger, Repressor Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Schizosaccharomyces, Trans-Activators, Transcription Factors, Transcription, Genetic
Added March 20, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase.
King JB, Gross J, Lovly CM, Rohrs H, Piwnica-Worms H, Townsend RR
(2006) Anal Chem 78: 2171-81
MeSH Terms: Amino Acid Sequence, Checkpoint Kinase 2, Cyclotrons, Humans, Isomerism, Molecular Sequence Data, Mutation, Phosphopeptides, Phosphoric Acids, Phosphorylation, Protein-Serine-Threonine Kinases, Reproducibility of Results, Sensitivity and Specificity, Spectrometry, Mass, Electrospray Ionization
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms