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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 13

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A whole genome RNAi screen identifies replication stress response genes.
Kavanaugh G, Ye F, Mohni KN, Luzwick JW, Glick G, Cortez D
(2015) DNA Repair (Amst) 35: 55-62
MeSH Terms: Cell Line, Tumor, Checkpoint Kinase 1, DNA Damage, DNA Repair, DNA Replication, DNA, Single-Stranded, Genome, Human, Genomic Instability, Genomics, Humans, Microscopy, Fluorescence, Protein Kinases, RNA Interference, RNA, Small Interfering
Added February 4, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells.
Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, Hiebert S, Bhalla KN
(2014) Oncotarget 5: 5637-50
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Ataxia Telangiectasia Mutated Proteins, BRCA1 Protein, Cell Line, Tumor, Checkpoint Kinase 1, Cisplatin, DNA Damage, Drug Synergism, Enzyme Inhibitors, Female, Gene Knockdown Techniques, HSP90 Heat-Shock Proteins, HeLa Cells, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Indoles, MCF-7 Cells, Mice, Panobinostat, Poly(ADP-ribose) Polymerase Inhibitors, Protein Kinases, Reactive Oxygen Species, Triple Negative Breast Neoplasms, Vorinostat, Xenograft Model Antitumor Assays
Added September 28, 2015
0 Communities
1 Members
0 Resources
28 MeSH Terms
Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase.
Luzwick JW, Nam EA, Zhao R, Cortez D
(2014) PLoS One 9: e99397
MeSH Terms: Amino Acid Sequence, Amino Acid Substitution, Ataxia Telangiectasia Mutated Proteins, Carrier Proteins, Checkpoint Kinase 1, DNA Replication, DNA-Binding Proteins, G2 Phase Cell Cycle Checkpoints, HCT116 Cells, HEK293 Cells, Humans, Hydroxyurea, Molecular Sequence Data, Nuclear Proteins, Phosphorylation, Protein Binding, Protein Kinases, Protein Structure, Secondary, Radiation, Ionizing, Serine, Signal Transduction, Ultraviolet Rays
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice.
Biswas S, Shi Q, Wernick A, Aiello A, Zinkel SS
(2013) Cell Death Differ 20: 869-77
MeSH Terms: Animals, Annexin A5, Apoptosis, Ataxia Telangiectasia Mutated Proteins, BH3 Interacting Domain Death Agonist Protein, Cell Cycle Proteins, Checkpoint Kinase 1, Chromosomal Proteins, Non-Histone, DNA Damage, DNA-Binding Proteins, Disease Models, Animal, Female, Leukemia, T-Cell, Male, Mice, Mice, Knockout, Protein Kinases, Protein-Serine-Threonine Kinases, T-Lymphocytes, Thymocytes, Tumor Suppressor Proteins, Tumor Suppressor p53-Binding Protein 1
Added August 22, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.
Liu Y, Bertram CC, Shi Q, Zinkel SS
(2011) Cell Death Differ 18: 841-52
MeSH Terms: Adaptor Proteins, Signal Transducing, Amino Acid Motifs, Amino Acid Sequence, Animals, Ataxia Telangiectasia Mutated Proteins, BH3 Interacting Domain Death Agonist Protein, Bone Marrow Cells, Caspase 8, Cell Cycle Proteins, Cell Line, Cell Proliferation, Checkpoint Kinase 1, Chromatin, Consensus Sequence, DNA Damage, DNA Replication, DNA-Binding Proteins, Gene Deletion, Humans, Hydroxyurea, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Mutation, Missense, Phosphorylation, Protein Binding, Protein Interaction Domains and Motifs, Protein Kinases, Protein-Serine-Threonine Kinases, RNA Interference, Replication Protein A, Signal Transduction, Stress, Physiological, cdc25 Phosphatases
Added September 7, 2011
1 Communities
1 Members
0 Resources
35 MeSH Terms
Checkpoint signaling from a single DNA interstrand crosslink.
Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J
(2009) Mol Cell 35: 704-15
MeSH Terms: Alkylating Agents, Animals, Ataxia Telangiectasia Mutated Proteins, Cell Cycle, Cell Cycle Proteins, Cell Proliferation, Checkpoint Kinase 1, DNA, DNA Damage, DNA Helicases, DNA Repair, DNA Replication, DNA-Directed DNA Polymerase, Fanconi Anemia Complementation Group A Protein, Fanconi Anemia Complementation Group D2 Protein, HeLa Cells, Humans, Nucleic Acid Conformation, Protein Kinases, Protein-Serine-Threonine Kinases, Recombinant Proteins, Replication Origin, Replication Protein A, Signal Transduction, Time Factors, Transfection, Xenopus Proteins, Xenopus laevis
Added January 7, 2016
0 Communities
1 Members
0 Resources
28 MeSH Terms
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.
Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA
(2007) J Cell Sci 120: 3565-77
MeSH Terms: Animals, Cell Cycle, Cell Cycle Proteins, Checkpoint Kinase 1, Checkpoint Kinase 2, Chromatin, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Genes, Insect, Genomic Instability, Mitosis, Mushroom Bodies, Mutation, Protein Kinases, Protein-Serine-Threonine Kinases
Added March 5, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Myers JS, Cortez D
(2006) J Biol Chem 281: 9346-50
MeSH Terms: Antineoplastic Agents, Ataxia Telangiectasia Mutated Proteins, Cell Cycle, Cell Cycle Proteins, Checkpoint Kinase 1, DNA Damage, DNA Repair, DNA-Binding Proteins, Humans, Hydroxyurea, Kinetics, MRE11 Homologue Protein, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, RNA, Small Interfering, Signal Transduction, Transfection, Tumor Suppressor Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation.
Ball HL, Myers JS, Cortez D
(2005) Mol Biol Cell 16: 2372-81
MeSH Terms: Adaptor Proteins, Signal Transducing, Ataxia Telangiectasia Mutated Proteins, Base Sequence, Binding Sites, Cell Cycle Proteins, Cell Line, Cell Nucleus, Checkpoint Kinase 1, DNA Damage, DNA, Single-Stranded, DNA-Binding Proteins, Exodeoxyribonucleases, Humans, In Vitro Techniques, Phosphoproteins, Phosphorylation, Protein Binding, Protein Kinases, Protein Structure, Tertiary, Protein-Serine-Threonine Kinases, RNA, Small Interfering, Replication Protein A, Signal Transduction, Transfection, Two-Hybrid System Techniques
Added March 5, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint.
Chen Z, Xiao Z, Chen J, Ng SC, Sowin T, Sham H, Rosenberg S, Fesik S, Zhang H
(2003) Mol Cancer Ther 2: 543-8
MeSH Terms: Apoptosis, Blotting, Western, Cell Cycle, Cell Death, Cell Line, Tumor, Checkpoint Kinase 1, DNA Damage, G2 Phase, HeLa Cells, Humans, Kinetics, Protein Kinases, RNA, Small Interfering, Tumor Suppressor Protein p53
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms