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Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G
(2020) Diabetes 69: 1219-1231
MeSH Terms: Aging, Animals, Basic Helix-Loop-Helix Transcription Factors, Calcium, Cell Survival, Diabetes Mellitus, Female, Gene Expression Regulation, Developmental, Homeostasis, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Nerve Tissue Proteins, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex
Added April 7, 2020
2 Communities
3 Members
0 Resources
16 MeSH Terms
Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese.
Horning KJ, Joshi P, Nitin R, Balachandran RC, Yanko FM, Kim K, Christov P, Aschner M, Sulikowski GA, Weaver CD, Bowman AB
(2020) J Biol Chem 295: 3875-3890
MeSH Terms: Animals, Calcimycin, Calcium, Cell Line, Cell Survival, Fura-2, HEK293 Cells, Humans, Induced Pluripotent Stem Cells, Ionomycin, Ionophores, Male, Manganese, Mass Spectrometry, Mice
Added March 27, 2020
0 Communities
1 Members
0 Resources
15 MeSH Terms
Systemic delivery of a Gli inhibitor via polymeric nanocarriers inhibits tumor-induced bone disease.
Vanderburgh JP, Kwakwa KA, Werfel TA, Merkel AR, Gupta MK, Johnson RW, Guelcher SA, Duvall CL, Rhoades JA
(2019) J Control Release 311-312: 257-272
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Bone Neoplasms, Cell Line, Tumor, Cell Proliferation, Cell Survival, Drug Carriers, Drug Liberation, Female, Gene Expression Regulation, Neoplastic, Humans, Mammary Neoplasms, Animal, Mesenchymal Stem Cells, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Nanoparticles, Osteogenesis, Polymers, Pyridines, Thiophenes, Zinc Finger Protein Gli2
Added March 3, 2020
0 Communities
4 Members
0 Resources
23 MeSH Terms
MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
Vilgelm AE, Saleh N, Shattuck-Brandt R, Riemenschneider K, Slesur L, Chen SC, Johnson CA, Yang J, Blevins A, Yan C, Johnson DB, Al-Rohil RN, Halilovic E, Kauffmann RM, Kelley M, Ayers GD, Richmond A
(2019) Sci Transl Med 11:
MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Cell Cycle, Cell Survival, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase Inhibitor p21, DNA Replication, Dimethyl Sulfoxide, Humans, Immunoprecipitation, MCF-7 Cells, Melanoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Proteomics, Proto-Oncogene Proteins c-mdm2, Radioimmunoprecipitation Assay
Added September 27, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.
Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK
(2019) Open Biol 9: 190117
MeSH Terms: Animals, Cell Survival, DNA Replication, DNA-Binding Proteins, Drug Discovery, Enzyme Inhibitors, Gene Expression, High-Throughput Nucleotide Sequencing, Humans, Kinetics, Minichromosome Maintenance Proteins, Molecular Structure, Protein Binding, Suramin, Xenopus
Added August 26, 2019
0 Communities
2 Members
0 Resources
15 MeSH Terms
Cell-free hemoglobin augments acute kidney injury during experimental sepsis.
Shaver CM, Paul MG, Putz ND, Landstreet SR, Kuck JL, Scarfe L, Skrypnyk N, Yang H, Harrison FE, de Caestecker MP, Bastarache JA, Ware LB
(2019) Am J Physiol Renal Physiol 317: F922-F929
MeSH Terms: Acute Kidney Injury, Animals, Cell Line, Cell Survival, Cell-Free System, Cytokines, Female, Glomerular Filtration Rate, Hemoglobins, Hepatitis A Virus Cellular Receptor 1, Kidney Tubules, Lipocalin-2, Male, Mice, Mice, Inbred C57BL, Sepsis, Survival Analysis
Added May 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis.
Linton MF, Moslehi JJ, Babaev VR
(2019) Int J Mol Sci 20:
MeSH Terms: Animals, Apoptosis, Atherosclerosis, Blood Cells, Cell Survival, Humans, Macrophage Activation, Macrophages, Phosphatidylinositol 3-Kinases, Protein Isoforms, Proto-Oncogene Proteins c-akt, Signal Transduction
Added November 12, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms
Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.
McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T
(2019) Cell Chem Biol 26: 863-877.e7
MeSH Terms: Animals, Cell Survival, HT29 Cells, Humans, Inositol Phosphates, Protein Kinases, Sf9 Cells, Spodoptera
Added March 30, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Zinc intoxication induces ferroptosis in A549 human lung cells.
Palmer LD, Jordan AT, Maloney KN, Farrow MA, Gutierrez DB, Gant-Branum R, Burns WJ, Romer CE, Tsui T, Allen JL, Beavers WN, Nei YW, Sherrod SD, Lacy DB, Norris JL, McLean JA, Caprioli RM, Skaar EP
(2019) Metallomics 11: 982-993
MeSH Terms: A549 Cells, Apoptosis, Cell Survival, Ferroptosis, Genomics, Humans, Lung, NAD, Necrosis, Protein Binding, Time Factors, Zinc
Added August 7, 2019
1 Communities
3 Members
0 Resources
12 MeSH Terms
Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms.
El Charif O, Mapes B, Trendowski MR, Wheeler HE, Wing C, Dinh PC, Frisina RD, Feldman DR, Hamilton RJ, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Kubo M, Gamazon ER, Cox NJ, Huddart R, Ardeshir-Rouhani-Fard S, Monahan P, Fossa SD, Einhorn LH, Travis LB, Dolan ME
(2019) Clin Cancer Res 25: 4104-4116
MeSH Terms: Adult, Aged, Antineoplastic Agents, Case-Control Studies, Cell Line, Tumor, Cell Survival, Cisplatin, Disease Susceptibility, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Middle Aged, Ototoxicity, Polymorphism, Single Nucleotide, Risk Factors, Self Report, Tinnitus, Young Adult
Added July 17, 2019
0 Communities
1 Members
0 Resources
18 MeSH Terms