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Results: 1 to 10 of 21

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AJP-Cell Physiology begins landmark reviews in cell physiology: an editorial from the senior editors of AJP-Cell Physiology.
Delpire E, Hamilton KL, Hawke TJ, Isenberg JS, Lotersztajn S, Yuan JX, Adams JC
(2018) Am J Physiol Cell Physiol 314: C1-C2
MeSH Terms: Biological Phenomena, Cell Physiological Phenomena, Endocrine System, Ions, Ouabain
Added April 3, 2018
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5 MeSH Terms
Exploring genetic suppression interactions on a global scale.
van Leeuwen J, Pons C, Mellor JC, Yamaguchi TN, Friesen H, Koschwanez J, Ušaj MM, Pechlaner M, Takar M, Ušaj M, VanderSluis B, Andrusiak K, Bansal P, Baryshnikova A, Boone CE, Cao J, Cote A, Gebbia M, Horecka G, Horecka I, Kuzmin E, Legro N, Liang W, van Lieshout N, McNee M, San Luis BJ, Shaeri F, Shuteriqi E, Sun S, Yang L, Youn JY, Yuen M, Costanzo M, Gingras AC, Aloy P, Oostenbrink C, Murray A, Graham TR, Myers CL, Andrews BJ, Roth FP, Boone C
(2016) Science 354:
MeSH Terms: Cell Physiological Phenomena, Chromosome Mapping, Gene Regulatory Networks, Genes, Fungal, Genes, Suppressor, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Suppression, Genetic
Show Abstract · Added April 6, 2017
Genetic suppression occurs when the phenotypic defects caused by a mutation in a particular gene are rescued by a mutation in a second gene. To explore the principles of genetic suppression, we examined both literature-curated and unbiased experimental data, involving systematic genetic mapping and whole-genome sequencing, to generate a large-scale suppression network among yeast genes. Most suppression pairs identified novel relationships among functionally related genes, providing new insights into the functional wiring diagram of the cell. In addition to suppressor mutations, we identified frequent secondary mutations,in a subset of genes, that likely cause a delay in the onset of stationary phase, which appears to promote their enrichment within a propagating population. These findings allow us to formulate and quantify general mechanisms of genetic suppression.
Copyright © 2016, American Association for the Advancement of Science.
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8 MeSH Terms
Targeting the untargeted in molecular phenomics with structurally-selective ion mobility-mass spectrometry.
May JC, Gant-Branum RL, McLean JA
(2016) Curr Opin Biotechnol 39: 192-197
MeSH Terms: Animals, Cell Physiological Phenomena, Computational Biology, Drug Discovery, Humans, Mass Spectrometry, Phenotype
Show Abstract · Added December 17, 2018
Systems-wide molecular phenomics is rapidly expanding through technological advances in instrumentation and bioinformatics. Strategies such as structural mass spectrometry, which utilizes size and shape measurements with molecular weight, serve to characterize the sum of molecular expression in biological contexts, where broad-scale measurements are made that are interpreted through big data statistical techniques to reveal underlying patterns corresponding to phenotype. The data density, data dimensionality, data projection, and data interrogation are all critical aspects of these approaches to turn data into salient information. Untargeted molecular phenomics is already having a dramatic impact in discovery science from drug discovery to synthetic biology. It is evident that these emerging techniques will integrate closely in broad efforts aimed at precision medicine.
Copyright © 2016 Elsevier Ltd. All rights reserved.
1 Communities
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MeSH Terms
A physiological role for connective tissue growth factor in early wound healing.
Alfaro MP, Deskins DL, Wallus M, DasGupta J, Davidson JM, Nanney LB, A Guney M, Gannon M, Young PP
(2013) Lab Invest 93: 81-95
MeSH Terms: Analysis of Variance, Animals, Burns, Cell Physiological Phenomena, Collagen, Connective Tissue Growth Factor, Culture Media, Conditioned, Humans, Immunohistochemistry, Membrane Proteins, Mesenchymal Stem Cells, Mice, Mice, Knockout, Proteomics, Skin, Up-Regulation, Wound Healing
Show Abstract · Added January 8, 2014
Mesenchymal stem cells (MSCs) that overexpress secreted frizzled-related protein 2 (sFRP2) exhibit an enhanced reparative phenotype. The secretomes of sFRP2-overexpressing MSCs and vector control-MSCs were compared through liquid chromatography tandem mass spectrometry. Proteomic profiling revealed that connective tissue growth factor (CTGF; CCN2) was overrepresented in the conditioned media of sFRP2-overexpressing MSCs and MSC-derived CTGF could thus be an important paracrine effector. Subcutaneously implanted, MSC-loaded polyvinyl alcohol (PVA) sponges and stented excisional wounds were used as wound models to study the dynamics of CTGF expression. Granulation tissue generated within the sponges and full-thickness skin wounds showed transient upregulation of CTGF expression by MSCs and fibroblasts, implying a role for this molecule in early tissue repair. Although collagen and COL1A2 mRNA were not increased when recombinant CTGF was administered to sponges during the early phase (day 1-6) of tissue repair, prolonged administration (>15 days) of exogenous CTGF into PVA sponges resulted in fibroblast proliferation and increased deposition of collagen within the experimental granulation tissue. In support of its physiological role, CTGF immunoinhibition during early repair (days 0-7) reduced the quantity, organizational quality and vascularity of experimental granulation tissue in the sponge model. However, CTGF haploinsufficiency was not enough to reduce collagen deposition in excisional wounds. Similar to acute murine wound models, CTGF was transiently present in the early phase of human acute burn wound healing. Together, these results further support a physiological role for CTGF in wound repair and demonstrate that when CTGF expression is confined to early tissue repair, it serves a pro-reparative role. These data also further illustrate the potential of MSC-derived paracrine modulators to enhance tissue repair.
2 Communities
2 Members
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17 MeSH Terms
Cannabinoids, endocannabinoids, and cancer.
Hermanson DJ, Marnett LJ
(2011) Cancer Metastasis Rev 30: 599-612
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Cannabinoid Receptor Agonists, Cannabinoid Receptor Antagonists, Cannabinoid Receptor Modulators, Cannabinoids, Cell Physiological Phenomena, Endocannabinoids, Humans, Neoplasms, Receptors, Cannabinoid, Signal Transduction
Show Abstract · Added March 7, 2014
The endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid receptors. Although the primary focus of endocannabinoid biology has been on neurological and psychiatric effects, recent work has revealed several important interactions between the endocannabinoid system and cancer. Several different types of cancer have abnormal regulation of the endocannabinoid system that contributes to cancer progression and correlates to clinical outcomes. Modulation of the endocannabinoid system by pharmacological agents in various cancer types reveals that it can mediate antiproliferative and apoptotic effects by both cannabinoid receptor-dependent and -independent pathways. Selective agonists and antagonists of the cannabinoid receptors, inhibitors of endocannabinoid hydrolysis, and cannabinoid analogs have been utilized to probe the pathways involved in the effects of the endocannabinoid system on cancer cell apoptosis, proliferation, migration, adhesion, and invasion. The antiproliferative and apoptotic effects produced by some of these pharmacological probes reveal that the endocannabinoid system is a promising new target for the development of novel chemotherapeutics to treat cancer.
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13 MeSH Terms
How do control-based approaches enter into biology?
LeDuc PR, Messner WC, Wikswo JP
(2011) Annu Rev Biomed Eng 13: 369-96
MeSH Terms: Animals, Cell Physiological Phenomena, Cells, Cytological Techniques, Feedback, Physiological, Humans, Models, Biological, Systems Biology
Show Abstract · Added March 27, 2014
Control is intrinsic to biological organisms, whose cells are in a constant state of sensing and response to numerous external and self-generated stimuli. Diverse means are used to study the complexity through control-based approaches in these cellular systems, including through chemical and genetic manipulations, input-output methodologies, feedback approaches, and feed-forward approaches. We first discuss what happens in control-based approaches when we are not actively examining or manipulating cells. We then present potential methods to determine what the cell is doing during these times and to reverse-engineer the cellular system. Finally, we discuss how we can control the cell's extracellular and intracellular environments, both to probe the response of the cells using defined experimental engineering-based technologies and to anticipate what might be achieved by applying control-based approaches to affect cellular processes. Much work remains to apply simplified control models and develop new technologies to aid researchers in studying and utilizing cellular and molecular processes.
1 Communities
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8 MeSH Terms
Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser desorption ionisation/nanoelectrospray ionisation-ion mobility-mass spectrometry platform.
Enders JR, Marasco CC, Kole A, Nguyen B, Sevugarajan S, Seale KT, Wikswo JP, McLean JA
(2010) IET Syst Biol 4: 416-27
MeSH Terms: Cell Biology, Cell Physiological Phenomena, Cell Separation, Cells, Humans, Jurkat Cells, Microfluidic Analytical Techniques, Saccharomyces cerevisiae, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Systems Biology
Show Abstract · Added March 7, 2014
The combination of microfluidic cell trapping devices with ion mobility-mass spectrometry offers the potential for elucidating in real time the dynamic responses of small populations of cells to paracrine signals, changes in metabolite levels and delivery of drugs and toxins. Preliminary experiments examining peptides in methanol and recording the interactions of yeast and Jurkat cells with their superfusate have identified instrumental set-up and control parameters and online desalting procedures. Numerous initial experiments demonstrate and validate this new instrumental platform. Future outlooks and potential applications are addressed, specifically how this instrumentation may be used for fully automated systems biology studies of the significantly interdependent, dynamic internal workings of cellular metabolic and signalling pathways.
1 Communities
2 Members
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10 MeSH Terms
Fluorescent protein tracking and detection: applications using fluorescent proteins in living cells.
Rizzo MA, Davidson MW, Piston DW
(2009) Cold Spring Harb Protoc 2009: pdb.top64
MeSH Terms: Animals, Biosensing Techniques, Cell Physiological Phenomena, Fluorescence, Fluorescence Resonance Energy Transfer, Green Fluorescent Proteins, HeLa Cells, Humans, Protein Interaction Mapping, Protein Transport
Added December 6, 2012
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10 MeSH Terms
Fluorescent protein tracking and detection: fluorescent protein structure and color variants.
Rizzo MA, Davidson MW, Piston DW
(2009) Cold Spring Harb Protoc 2009: pdb.top63
MeSH Terms: Animals, Biosensing Techniques, Cell Physiological Phenomena, Color, Fluorescence, Gene Expression, Green Fluorescent Proteins, Protein Conformation, Protein Transport
Added December 6, 2012
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9 MeSH Terms
Applications of small molecule BMP inhibitors in physiology and disease.
Hong CC, Yu PB
(2009) Cytokine Growth Factor Rev 20: 409-18
MeSH Terms: Animals, Bone Diseases, Bone Morphogenetic Protein Receptors, Type I, Bone Morphogenetic Proteins, Cell Physiological Phenomena, Embryo, Nonmammalian, Humans, Models, Biological, Osteogenesis, Pyrazoles, Pyrimidines, Signal Transduction, Small Molecule Libraries, Zebrafish
Show Abstract · Added August 19, 2012
Bone morphogenetic proteins (BMPs) provide critical signals for determining cell fate, specifying gastrulation, embryonic patterning, organogenesis, and the remodeling of diverse tissues. Recent work has suggested that in addition to coordinating pivotal events in development, BMPs may also regulate certain homeostatic physiological processes independently of effects on cell growth or differentiation. We recently described the identification of dorsomorphin, a small molecule inhibitor of BMP type I receptors which inhibits BMP signaling in preference to TGF-beta, Activin, and other ligands of the TGF-beta family. We describe a number of strategies using dorsomorphin and its derivatives as probes to assess the physiologic roles of BMP signaling. We also discuss several potential applications for small molecule BMP inhibitors, including stem cell manipulation, and the therapeutic modification of bone remodeling, heterotopic ossification, and iron homeostasis.
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14 MeSH Terms