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Results: 1 to 10 of 566

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DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.
Bhattacharjee R, Mangione MC, Wos M, Chen JS, Snider CE, Roberts-Galbraith RH, McDonald NA, Presti LL, Martin SG, Gould KL
(2020) Mol Biol Cell 31: 917-929
MeSH Terms: Cell Cycle Proteins, Cytokinesis, Cytoskeletal Proteins, GTP-Binding Proteins, Phosphorylation, Protein Kinases, Protein Processing, Post-Translational, Schizosaccharomyces, Schizosaccharomyces pombe Proteins
Added March 3, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
Salivary Gland NUT Carcinoma with Prolonged Survival in Children: Case Illustration and Systematic Review of Literature.
Wang H, Weiss VL, Hoffman RD, Abel T, Ho RH, Borinstein SC, Mannion K, Bridge JA, Black J, Liang J
(2021) Head Neck Pathol 15: 236-243
MeSH Terms: Carcinoma, Cell Cycle Proteins, Child, Fatal Outcome, Humans, Male, Mutation, Neoplasm Proteins, Nuclear Proteins, Oncogene Proteins, Fusion, Salivary Gland Neoplasms, Transcription Factors
Added March 3, 2020
0 Communities
1 Members
0 Resources
12 MeSH Terms
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
Tian J, Teuscher KB, Aho ER, Alvarado JR, Mills JJ, Meyers KM, Gogliotti RD, Han C, Macdonald JD, Sai J, Shaw JG, Sensintaffar JL, Zhao B, Rietz TA, Thomas LR, Payne WG, Moore WJ, Stott GM, Kondo J, Inoue M, Coffey RJ, Tansey WP, Stauffer SR, Lee T, Fesik SW
(2020) J Med Chem 63: 656-675
MeSH Terms: Antineoplastic Agents, Bridged Bicyclo Compounds, Heterocyclic, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Chromatin, Crystallography, X-Ray, Drug Design, Drug Discovery, Epigenetic Repression, Genes, myc, Humans, Intracellular Signaling Peptides and Proteins, Quinolones, Structure-Activity Relationship, WD40 Repeats
Added March 3, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 performs a unique essential function in maintenance of cytokinetic ring integrity.
Mangione MC, Snider CE, Gould KL
(2019) Mol Biol Cell 30: 2790-2801
MeSH Terms: Cell Cycle Proteins, Cell Division, Cytokinesis, Cytoskeletal Proteins, GTP-Binding Proteins, Protein Domains, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, src Homology Domains
Added March 3, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
Vilgelm AE, Saleh N, Shattuck-Brandt R, Riemenschneider K, Slesur L, Chen SC, Johnson CA, Yang J, Blevins A, Yan C, Johnson DB, Al-Rohil RN, Halilovic E, Kauffmann RM, Kelley M, Ayers GD, Richmond A
(2019) Sci Transl Med 11:
MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Cell Cycle, Cell Survival, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase Inhibitor p21, DNA Replication, Dimethyl Sulfoxide, Humans, Immunoprecipitation, MCF-7 Cells, Melanoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Proteomics, Proto-Oncogene Proteins c-mdm2, Radioimmunoprecipitation Assay
Added September 27, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts.
Steenwyk JL, Opulente DA, Kominek J, Shen XX, Zhou X, Labella AL, Bradley NP, Eichman BF, Čadež N, Libkind D, DeVirgilio J, Hulfachor AB, Kurtzman CP, Hittinger CT, Rokas A
(2019) PLoS Biol 17: e3000255
MeSH Terms: Base Sequence, Cell Cycle, DNA Damage, DNA Repair, Evolution, Molecular, Genes, Fungal, Phenotype, Phylogeny, Saccharomycetales
Added August 26, 2019
0 Communities
1 Members
0 Resources
9 MeSH Terms
Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.
Cao Z, Singh B, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, Coffey RJ
(2019) Traffic 20: 357-368
MeSH Terms: A Kinase Anchor Proteins, Adaptor Proteins, Signal Transducing, Animals, Caco-2 Cells, Calcium-Binding Proteins, Cell Cycle Proteins, Cell Membrane, Cyclic AMP-Dependent Protein Kinases, Dinoprostone, Dogs, ErbB Receptors, HEK293 Cells, Humans, Madin Darby Canine Kidney Cells, Protein Transport, Signal Transduction, Transforming Growth Factor alpha, Vasoactive Intestinal Peptide
Added March 3, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.
Willet AH, DeWitt AK, Beckley JR, Clifford DM, Gould KL
(2019) Curr Biol 29: 1055-1063.e2
MeSH Terms: Actin Cytoskeleton, Cell Cycle Checkpoints, Cytokinesis, Mitosis, Phosphorylation, Protein Kinases, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Signal Transduction
Added April 10, 2019
0 Communities
1 Members
0 Resources
9 MeSH Terms
Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion.
Sedgeman LR, Beysen C, Ramirez Solano MA, Michell DL, Sheng Q, Zhao S, Turner S, Linton MF, Vickers KC
(2019) Sci Rep 9: 3803
MeSH Terms: Animals, Biological Transport, Cell Cycle, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Lipoproteins, HDL, Mice, Mice, Transgenic, MicroRNAs
Added April 10, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms
The F-BAR Domain of Rga7 Relies on a Cooperative Mechanism of Membrane Binding with a Partner Protein during Fission Yeast Cytokinesis.
Liu Y, McDonald NA, Naegele SM, Gould KL, Wu JQ
(2019) Cell Rep 26: 2540-2548.e4
MeSH Terms: Animals, COS Cells, Cell Cycle Proteins, Cell Membrane, Chlorocebus aethiops, Cytokinesis, GTPase-Activating Proteins, Microscopy, Confocal, Protein Domains, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Transfection
Added April 10, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms