Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 10 of 173

Publication Record

Connections

Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles.
Manthei KA, Patra D, Wilson CJ, Fawaz MV, Piersimoni L, Shenkar JC, Yuan W, Andrews PC, Engen JR, Schwendeman A, Ohi MD, Tesmer JJG
(2020) Commun Biol 3: 28
MeSH Terms: Binding Sites, Catalytic Domain, Lipoproteins, HDL, Lysine, Mass Spectrometry, Models, Molecular, Multiprotein Complexes, Phosphatidylcholine-Sterol O-Acyltransferase, Protein Binding, Protein Conformation, Recombinant Proteins, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
12 MeSH Terms
Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.
Friggeri L, Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI
(2019) J Med Chem 62: 10391-10401
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Catalytic Domain, Crystallography, X-Ray, Drug Design, Humans, Molecular Structure, Mutagenesis, Site-Directed, Protozoan Proteins, Sterol 14-Demethylase
Added March 3, 2020
0 Communities
2 Members
0 Resources
10 MeSH Terms
In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds.
Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA
(2020) J Med Chem 63: 6477-6488
MeSH Terms: Alkynes, Allosteric Site, Benzoxazines, Catalytic Domain, Cholesterol, Cholesterol 24-Hydroxylase, Cyclopropanes, Cytochrome P-450 CYP3A Inducers, Humans, Hydroxylation, In Vitro Techniques, Pharmaceutical Preparations, Protein Conformation
Added March 3, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Synthesis and Characterization of Site-Specific O -Alkylguanine DNA-Alkyl Transferase-Oligonucleotide Crosslinks.
Ghodke PP, Albertolle ME, Johnson KM, Guengerich FP
(2019) Curr Protoc Nucleic Acid Chem 76: e74
MeSH Terms: Catalysis, Catalytic Domain, Chromatography, Liquid, Copper, Cross-Linking Reagents, Escherichia coli, O(6)-Methylguanine-DNA Methyltransferase, Oligonucleotides, Polymerization, Tandem Mass Spectrometry, Templates, Genetic, Trypsin
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains.
Starbird CA, Perry NA, Chen Q, Berndt S, Yamakawa I, Loukachevitch LV, Limbrick EM, Bachmann BO, Iverson TM, McCulloch KM
(2018) Biochemistry 57: 6827-6837
MeSH Terms: Amino Acid Sequence, Aminoglycosides, Bacterial Proteins, Biosynthetic Pathways, Catalytic Domain, Conserved Sequence, Crystallography, X-Ray, Gene Fusion, Genes, Bacterial, Methyltransferases, Micromonospora, Models, Molecular, Oxygenases, Protein Interaction Domains and Motifs, Sequence Homology, Amino Acid
Added April 1, 2019
0 Communities
1 Members
0 Resources
15 MeSH Terms
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.
Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI
(2018) J Med Chem 61: 5679-5691
MeSH Terms: 14-alpha Demethylase Inhibitors, Antifungal Agents, Aspergillus fumigatus, Candida albicans, Catalytic Domain, Chemistry Techniques, Synthetic, Crystallography, X-Ray, Drug Design, Imidazoles, Ligands, Models, Molecular, Sterol 14-Demethylase
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ
(2018) J Biol Chem 293: 3028-3038
MeSH Terms: Amidohydrolases, Catalytic Domain, Cyclooxygenase Inhibitors, Isoenzymes, Phenylcarbamates, Phenylpropionates, Prostaglandin-Endoperoxide Synthases, Protein Binding, Stereoisomerism, Substrate Specificity
Added April 22, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement.
Starbird CA, Tomasiak TM, Singh PK, Yankovskaya V, Maklashina E, Eisenbach M, Cecchini G, Iverson TM
(2018) J Struct Biol 202: 100-104
MeSH Terms: Binding Sites, Catalytic Domain, Crystallography, Crystallography, X-Ray, Escherichia coli Proteins, Ligands, Membrane Proteins, Models, Molecular, Oxidoreductases, Protein Domains, Rotation
Added April 1, 2019
0 Communities
1 Members
0 Resources
11 MeSH Terms
Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.
Shi R, Mullins EA, Shen XX, Lay KT, Yuen PK, David SS, Rokas A, Eichman BF
(2018) EMBO J 37: 63-74
MeSH Terms: Adenine, Alkylation, Amino Acid Sequence, Bacillus cereus, Catalytic Domain, Crystallography, X-Ray, DNA Adducts, DNA Damage, DNA Glycosylases, DNA Repair, Models, Molecular, Protein Conformation, Sequence Homology
Added March 21, 2018
0 Communities
2 Members
0 Resources
13 MeSH Terms
A Polymerase With Potential: The Fe-S Cluster in Human DNA Primase.
Holt ME, Salay LE, Chazin WJ
(2017) Methods Enzymol 595: 361-390
MeSH Terms: Catalytic Domain, DNA, DNA Primase, DNA Primers, DNA Replication, Humans, Iron-Sulfur Proteins, Oxidation-Reduction, RNA, Sequence Analysis
Added March 24, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms