Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 10 of 310

Publication Record

Connections

A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis.
Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI
(2020) J Biol Chem 295: 9998-10007
MeSH Terms: Aromatase, Catalysis, Cholesterol Side-Chain Cleavage Enzyme, Crystallography, X-Ray, Humans, Protons, Sterol 14-Demethylase
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α.
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ
(2019) Biochemistry 58: 5102-5106
MeSH Terms: Biocatalysis, Casein Kinase Ialpha, Enzyme Activation, HEK293 Cells, Humans, Kinetics, Pyrvinium Compounds
Added December 22, 2019
0 Communities
1 Members
0 Resources
7 MeSH Terms
Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications.
Li Z, Jiang Y, Guengerich FP, Ma L, Li S, Zhang W
(2020) J Biol Chem 295: 833-849
MeSH Terms: Biocatalysis, Biotechnology, Cytochrome P-450 Enzyme System, Metabolic Engineering, Protein Engineering, Steroids, Substrate Specificity, Xenobiotics
Added March 3, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Reddish MJ, Guengerich FP
(2019) J Biol Chem 294: 12975-12991
MeSH Terms: 18-Hydroxycorticosterone, Aldosterone, Biocatalysis, Cytochrome P-450 CYP11B2, Humans, Kinetics, Models, Molecular, Molecular Conformation
Added March 3, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes.
Guengerich FP, Wilkey CJ, Phan TTN
(2019) J Biol Chem 294: 10928-10941
MeSH Terms: Catalysis, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2E1, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Lauric Acids, Ligands, Molecular Conformation, Oxidation-Reduction, Palmitic Acid, Protein Binding, Protein Conformation, Spiro Compounds, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Synthesis and Characterization of Site-Specific O -Alkylguanine DNA-Alkyl Transferase-Oligonucleotide Crosslinks.
Ghodke PP, Albertolle ME, Johnson KM, Guengerich FP
(2019) Curr Protoc Nucleic Acid Chem 76: e74
MeSH Terms: Catalysis, Catalytic Domain, Chromatography, Liquid, Copper, Cross-Linking Reagents, Escherichia coli, O(6)-Methylguanine-DNA Methyltransferase, Oligonucleotides, Polymerization, Tandem Mass Spectrometry, Templates, Genetic, Trypsin
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation.
McGough MAP, Shiels SM, Boller LA, Zienkiewicz KJ, Duvall CL, Wenke JC, Guelcher SA
(2019) Tissue Eng Part A 25: 949-963
MeSH Terms: Animals, Autografts, Bone Transplantation, Calcium Phosphates, Catalysis, Cell Line, Mice, Models, Biological, Osteogenesis, Polyurethanes, Rabbits, Rats, Nude, Sheep, X-Ray Microtomography
Added April 10, 2019
0 Communities
2 Members
0 Resources
14 MeSH Terms
Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51.
Hargrove TY, Wawrzak Z, Fisher PM, Child SA, Nes WD, Guengerich FP, Waterman MR, Lepesheva GI
(2018) J Biol Chem 293: 19344-19353
MeSH Terms: Biocatalysis, Electron Transport, Enzyme Stability, Heme, Models, Molecular, Protein Binding, Protein Conformation, Sterol 14-Demethylase, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS.
Maklashina E, Rajagukguk S, Iverson TM, Cecchini G
(2018) J Biol Chem 293: 7754-7765
MeSH Terms: Bacterial Proteins, Catalysis, Crystallography, X-Ray, Electron Transport Complex II, Escherichia coli, Flavoproteins, Humans, Models, Molecular, Oxidation-Reduction, Protein Conformation, Protein Subunits, Reactive Oxygen Species
Added April 1, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug-Metabolizing Enzymes as a Response to Redox Alteration.
Albertolle ME, Phan TTN, Pozzi A, Guengerich FP
(2018) Mol Cell Proteomics 17: 889-900
MeSH Terms: Animals, Biocatalysis, Cysteine, Cytochrome P-450 Enzyme System, Humans, Hydrogen Peroxide, Kidney, Mice, Transgenic, Microsomes, Liver, Oxidation-Reduction, Pharmaceutical Preparations, Recombinant Proteins, Staining and Labeling, Sulfenic Acids, Sulfhydryl Compounds
Added March 14, 2018
1 Communities
1 Members
0 Resources
15 MeSH Terms