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An Incidental Hypervascular Retroperitoneal Mass.
Costacurta PW, Shaver AC, Idrees K
(2017) JAMA Surg 152: 887-888
MeSH Terms: Aged, Castleman Disease, Diagnosis, Differential, Humans, Incidental Findings, Male, Retroperitoneal Neoplasms, Tomography, X-Ray Computed, Treatment Outcome
Added April 10, 2018
0 Communities
1 Members
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9 MeSH Terms
Castleman disease in a pediatric liver transplant recipient: a case report and literature review.
Bonatti HJ, Axt J, Hunter EB, Lott SL, Frangoul H, Gillis L, Correa H, Kelly B
(2012) Pediatr Transplant 16: E229-34
MeSH Terms: Adolescent, Adult, Antigens, CD20, B-Lymphocytes, CD3 Complex, Castleman Disease, Graft Survival, Herpesvirus 8, Human, Humans, Immunosuppressive Agents, Infant, Newborn, Liver Failure, Liver Transplantation, Lymphatic Diseases, Male, Middle Aged, Polymerase Chain Reaction, Sirolimus, Splenomegaly, T-Lymphocytes, Tacrolimus, Tomography, X-Ray Computed
Show Abstract · Added March 27, 2014
Castleman disease is a rare hematologic disorder, closely linked to the HHV-8, and most commonly observed in immunocompromised individuals. Thirteen months following a liver transplant for CPS-1 defect, a 15-month-old boy presented with fevers, anemia, and growth retardation. Abdominal CT scan showed splenomegaly and generalized lymphadenopathy. Histology of chest wall lymph nodes revealed a mixed CD3+ T-cell and CD20+ B-cell population with atretic germinal centers consistent with multicentric Castleman disease. Qualitative DNA PCR detected HHV-8 in the resected lymph node and in the blood, supporting the diagnosis. Immunosuppression was tapered, and he was transitioned from tacrolimus to sirolimus. His graft function remained stable, and repeat imaging showed regression of the lymphadenopathy. The child is living one yr after Castleman disease diagnosis with a well-functioning graft. Castleman disease is a potential complication of solid organ transplant and HHV-8 infection. Reduction in immunosuppression and switch to sirolimus may be an effective strategy to treat this condition.
© 2011 John Wiley & Sons A/S.
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22 MeSH Terms
Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.
Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW
(1990) J Clin Invest 86: 592-9
MeSH Terms: Animals, Blotting, Southern, Castleman Disease, Gene Expression Regulation, Gene Rearrangement, B-Lymphocyte, Genes, Immunoglobulin, Genetic Vectors, Hematopoietic Stem Cells, Interleukin-6, Kidney, Leukocyte Count, Mice, Mice, Inbred Strains, RNA, Messenger, Retroviridae, Transfection
Show Abstract · Added March 5, 2014
Interleukin 6 (IL-6) is an important regulator of the acute phase response, T cell function, and terminal B cell differentiation. Excessive or inappropriate production of this cytokine may be involved in a variety of autoimmune and neoplastic disorders. To investigate the consequences of dysregulated synthesis of IL-6 in vivo, a high-titer recombinant retroviral vector produced in psi-2 packaging cells was used to introduce the coding sequences of murine IL-6 into mouse hematopoietic cells. Congenitally anemic W/Wv mice reconstituted with bone marrow cells transduced with the retroviral vector developed a syndrome characterized by anemia, transient granulocytosis, hypoalbuminemia, and polyclonal hypergammaglobulinemia, with marked splenomegaly and peripheral lymphadenopathy. Extensive plasma cell infiltration of lymph nodes, spleen, liver, and lung was noted. The similarity of these findings to those of multicentric Castleman's disease, taken together with the observation that lymph nodes from these patients elaborate large amounts of this cytokine, suggest that the inappropriate synthesis of IL-6 has a primary role in the pathogenesis of this systemic lymphoproliferative disorder.
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16 MeSH Terms
Retroviral-mediated transfer of interleukin-6 into hematopoietic cells of mice results in a syndrome resembling Castleman's disease.
Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW
(1990) Curr Top Microbiol Immunol 166: 37-41
MeSH Terms: Animals, Bone Marrow Transplantation, Castleman Disease, Interleukin-6, Mice, Mice, Inbred C57BL, Retroviridae, Transfection
Added March 5, 2014
0 Communities
1 Members
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8 MeSH Terms