Cleavage of arrestin-3 by caspases attenuates cell death by precluding arrestin-dependent JNK activation.
Kook S, Vishnivetskiy SA, Gurevich VV, Gurevich EV
(2019) Cell Signal 54
: 161-169MeSH Terms: Animals, Apoptosis, Arrestins, COS Cells, Caspases, Chlorocebus aethiops, Etoposide, MAP Kinase Kinase 4, MAP Kinase Kinase Kinase 5Added March 18, 2020
9 MeSH Terms
Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models.
Liu Y, Hawkins OE, Vilgelm AE, Pawlikowski JS, Ecsedy JA, Sosman JA, Kelley MC, Richmond A
(2015) Clin Cancer Res 21
: 5338-48MeSH Terms: Animals, Antibodies, Monoclonal, Antineoplastic Agents, Apoptosis, Aurora Kinases, Azepines, Caspases, Cell Line, Tumor, Cellular Senescence, Disease Models, Animal, Drug Evaluation, Preclinical, Female, Humans, Melanoma, Mice, Protein Kinase Inhibitors, Pyrimidines, Receptors, Death Domain, Receptors, TNF-Related Apoptosis-Inducing Ligand, Receptors, Tumor Necrosis Factor, Member 10c, Signal Transduction, TNF-Related Apoptosis-Inducing Ligand, Tumor Suppressor Protein p53, Xenograft Model Antitumor AssaysAdded August 21, 2015
24 MeSH Terms
Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium.
Chaum E, Winborn CS, Bhattacharya S
(2015) Mamm Genome 26
: 210-21MeSH Terms: Adult, Aged, 80 and over, Aging, Animals, Apoptosis, Caspases, Caspases, Initiator, Cell Line, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p21, Gene Expression Regulation, Humans, Immunity, Innate, Interferon-alpha, Interferon-gamma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Primary Cell Culture, Quantitative Trait Loci, Retinal Pigment Epithelium, Signal Transduction, Toll-Like Receptor 4, Tumor Suppressor Protein p53Added June 11, 2018
25 MeSH Terms
Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro.
Kaushal N, Robson MJ, Rosen A, McCurdy CR, Matsumoto RR
(2014) Eur J Pharmacol 724
: 193-203MeSH Terms: Animals, Apoptosis, Benzoxazoles, Caspases, Cell Line, Tumor, Fever, Ligands, Methamphetamine, Mice, Necrosis, Neuroprotective Agents, Piperazines, Reactive Nitrogen Species, Reactive Oxygen Species, Receptors, sigma, eIF-2 KinaseAdded August 26, 2015
16 MeSH Terms
Arrestins in apoptosis.
Kook S, Gurevich VV, Gurevich EV
(2014) Handb Exp Pharmacol 219
: 309-39MeSH Terms: Animals, Apoptosis, Arrestins, Caspases, DNA Damage, Endoplasmic Reticulum Stress, Humans, MAP Kinase Signaling System, Signal Transduction, Tumor Suppressor Protein p53, beta-ArrestinsAdded February 12, 2015
11 MeSH Terms
Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.
Egnatchik RA, Leamy AK, Noguchi Y, Shiota M, Young JD
(2014) Metabolism 63
: 283-95MeSH Terms: Acetylcysteine, Animals, Antioxidants, Apoptosis, Carbon Isotopes, Carcinoma, Hepatocellular, Caspases, Effector, Cell Line, Tumor, Enzyme Activation, Hepatocytes, Liver Neoplasms, Metabolic Flux Analysis, Mitochondria, Liver, Oxidative Stress, Palmitates, Rats, Reactive Oxygen SpeciesAdded January 23, 2015
17 MeSH Terms
Caspase-cleaved arrestin-2 and BID cooperatively facilitate cytochrome C release and cell death.
Kook S, Zhan X, Cleghorn WM, Benovic JL, Gurevich VV, Gurevich EV
(2014) Cell Death Differ 21
: 172-84MeSH Terms: Animals, Apoptosis, Arrestins, BH3 Interacting Domain Death Agonist Protein, Caspase 3, Caspases, Cell Line, Cytochromes c, Etoposide, Mice, Mitochondria, Protein Binding, Protein Isoforms, Recombinant Proteins, Tumor Necrosis Factor-alphaAdded February 12, 2015
15 MeSH Terms
Human embryonic stem cells: living on the edge.
Gama V, Deshmukh M
(2012) Cell Cycle 11
: 3905-6MeSH Terms: Apoptosis, Caspases, Cell Differentiation, Cytochromes c, DNA Damage, Embryonic Stem Cells, Golgi Apparatus, Humans, Mitochondria, bcl-2-Associated X ProteinAdded October 26, 2015
10 MeSH Terms
Resistance to TRAIL is mediated by DARPP-32 in gastric cancer.
Belkhiri A, Zhu S, Chen Z, Soutto M, El-Rifai W
(2012) Clin Cancer Res 18
: 3889-900MeSH Terms: Apoptosis, CASP8 and FADD-Like Apoptosis Regulating Protein, Caspases, Cell Line, Tumor, Cell Transformation, Neoplastic, Dopamine and cAMP-Regulated Phosphoprotein 32, Gene Expression Regulation, Neoplastic, Humans, NF-kappa B, Signal Transduction, Stomach Neoplasms, TNF-Related Apoptosis-Inducing Ligand, bcl-X ProteinAdded September 3, 2013
13 MeSH Terms
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor.
Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt MW, Hu T, Ren X, Wilson KT, Polk DB, Yan F
(2012) PLoS One 7
: e36418MeSH Terms: Active Transport, Cell Nucleus, Animals, Antineoplastic Agents, Apoptosis Inducing Factor, Berberine, Caspases, Cathepsin B, Cell Death, Cell Line, Tumor, Cell Nucleus, Colonic Neoplasms, Epithelial Cells, Humans, L-Lactate Dehydrogenase, Mice, Mitochondria, Poly(ADP-ribose) Polymerases, Reactive Oxygen SpeciesAdded March 5, 2014
18 MeSH Terms